Effect of rifaximin on gut-lung axis in mice infected with influenza A virus

Chen, Yafei; Jiang, Zuoyi; Lei, Zhihai; Ping, Jihui; Su, Juan

doi:10.1016/j.cimid.2021.101611

Cited by 11 publications

(6 citation statements)

References 52 publications

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“…The gut microbiota is composed of a large number of different microorganisms in a complex manner and contains not only bacteria but also many viruses, fungi, and mycetes. Additionally, it has been suggested that certain viruses may cause dysbiosis and endotoxemia, exacerbating the disease state [ 41 , 42 ]. However, there is also a report that rifaximin is effective against dysbiosis associated with viral infection and optimizes intestinal permeability [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, it has been suggested that certain viruses may cause dysbiosis and endotoxemia, exacerbating the disease state [ 41 , 42 ]. However, there is also a report that rifaximin is effective against dysbiosis associated with viral infection and optimizes intestinal permeability [ 42 ]. Considering that it is also effective for diseases in which the microbiome is deeply involved, such as irritable bowel syndrome and small intestine bacterial overgrowth [ 5 ], there is strong evidence that rifaximin modulates gut microbiota metabolism.…”

Section: Discussionmentioning

confidence: 99%

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Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation

Kitsugi

Kawata

Noritake

et al. 2023

JCM

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Rifaximin, a non-absorbable antibiotic, has been demonstrated to be effective against hepatic encephalopathy (HE); however, its efficacy on liver functional reserve remains unknown. Here, we evaluated the efficacy of rifaximin on the liver functional reserve and serological inflammation-based markers in patients with cirrhosis. A retrospective study was conducted on patients who received rifaximin for more than three months at our hospital between November 2016 and October 2021. The recurrence and grade of HE, serological ammonia levels, Child–Pugh score (CPS), and serological inflammation-based markers such as the neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), platelet–lymphocyte ratio (PLR), C-reactive protein (CRP), and CRP to albumin ratio (CAR) were evaluated. The correlations between serological inflammation-based markers and liver functional reserve were evaluated. HE grades, serum ammonia levels, and inflammation-based markers significantly improved at three months compared with those at baseline. Patients with improved albumin levels showed significantly higher CRP improvement rates at both 3 and 12 months. Patients with an improvement in CAR at 3 months demonstrated a significant improvement in CPS at 12 months. Rifaximin improved the liver functional reserve in patients with cirrhosis. Improvements in inflammation-based markers, particularly CRP and albumin, may be involved in this process.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation

Kitsugi

Kawata

Noritake

et al. 2023

JCM

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“…Rifaximin is an antibiotic that can effectively ameliorate lung and gut damage caused by the influenza virus. It reduces lung and gut permeability by enhancing tight junction protein expression, thus maintaining microbiota stability [ 80 ]. Additionally, food reflux or microinhalation can direct gut microbiota to the lungs to mediate immune responses [ 81 , 82 ].…”

Section: The Microbiota and Glamentioning

confidence: 99%

What Makes the Gut-Lung Axis Working? From the Perspective of Microbiota and Traditional Chinese Medicine

Wang,

Wang

2024

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. An increasing number of studies have proved that gut microbiota is involved in the occurrence and development of various lung diseases and can interact with the diseased lung. The concept of the gut-lung axis (GLA) provides a new idea for the subsequent clinical treatment of lung diseases through human microbiota. This review aims to summarize the microbiota in the lung and gut and the interaction between them from the perspectives of traditional Chinese medicine and modern medicine. Method. We conducted a literature search by using the search terms “GLA,” “gut microbiota,” “spleen,” and “Chinese medicine” in the databases PubMed, Web of Science, and CNKI. We then explored the mechanism of action of the gut-lung axis from traditional Chinese medicine and modern medicine. Results. The lung and gut microbiota enable the GLA to function through immune regulation, while metabolites of the gut microbiota also play an important role. The spleen can improve the gut microbiota to achieve the regulation of the GLA. Conclusion. Improving the gut microbiota through qi supplementation and spleen fortification provides a new approach to the clinical treatment of lung diseases by regulating the GLA. Currently, our understanding of the GLA is limited, and more research is needed to explain its working principle.

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“…The lung and intestine belong to the respiratory system and the digestive system, respectively. However, modern medicine believes that the lung and intestine are closely related, and ancient Chinese medicine also stated thas "Lungs and large intestines are the exterior and interior of each other" (Chen et al, 2021). Therefore, whether the effect mechanism of drug is related to the gut-lung axis deserves further study.…”

Section: Differential Assessment Of Tissue Distributionmentioning

confidence: 99%

The tissue distribution of Jinzhen oral liquid in healthy and influenza mice

Chen

Gao

Cao

et al. 2023

Biomedical Chromatography

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Jinzhen oral liquid (JZOL) is widely used in China. However, its tissue distribution, a vital part of the efficacy substances research, has not been reported yet. This study characterized its chemical components and its prototypes and metabolites in mice, and investigated its tissue distribution in pathological and healthy mice. Several constituents were characterized, including 55 constituents in JZOL, 11 absorbed prototypes and six metabolites in plasma and tissues. The metabolic pathways were demethylation, dehydration and acetylation. A sensitive, accurate and stable quantitative method was established and applied to the tissue distribution. After administration of JZOL, these seven components were rapidly distributed to various tissues, mainly staying in the small intestine, and less distributed to lung, liver and kidney.Compared with healthy mice, the absorption of baicalin, wogonoside, rhein, glycyrrhizic acid and liquiritin apioside was reduced in influenza mice, but their elimination was slow. However, influenza infection had no obvious effect on the overall distribution of the most important components (baicalin, glycyrrhizic acid and wogonoside) in the plasma or small intestine, but obviously affected the distribution of baicalin in liver. In summary, seven components are rapidly distributed to various tissues, and influenza infection has certain influence on the tissue distribution of JZOL.

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Effect of rifaximin on gut-lung axis in mice infected with influenza A virus

Cited by 11 publications

References 52 publications

Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation

Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation

What Makes the Gut-Lung Axis Working? From the Perspective of Microbiota and Traditional Chinese Medicine

The tissue distribution of Jinzhen oral liquid in healthy and influenza mice

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