Effect of root-extracts of Ficus benghalensis (Banyan) in memory, anxiety, muscle co-ordination and seizure in animal models

Panday, Dipesh Raj; Rauniar, Gajendra Prasad

doi:10.1186/s12906-016-1413-5

Cited by 19 publications

(12 citation statements)

References 31 publications

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“…Recent scientific studies have demonstrated anti-inflammatory potency on adjuvant induced arthritis [23] and antioxidant effects of Ficus benghalensis [23]. When tested in albino mice, extracts of aerial roots demonstrated better cognition, muscular relaxation and seizure reduction [24]. Different parts of Ficus benghalensis L have been known traditionally to resolve ailments related to the central nervous system [25] and many researchers have described various neuropharmacological effects of this plant [26].…”

Section: Introductionmentioning

confidence: 99%

Amelioration of Scopolamine-Induced Amnesic, Anxiolytic and Antidepressant Effects of Ficus benghalensis in Behavioral Experimental Models

Malik¹,

Javaid²,

Rasool³

et al. 2020

Medicina

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Background and Objectives: Ficus benghalensis (FB) is a commonly found tree in Pakistan and its various parts have folkloric importance in managing neurological ailments. In the present study, methanolic extract of its bark has been tested on an experimental animal model to evaluate memory-enhancing, anxiolytic and antidepressant activities to validate the claimed therapeutic potential. Materials and Methods: Methanolic extract of freshly isolated bark was prepared and subjected to preliminary phytochemical studies and gas chromatography–mass spectrometry (GC–MS) analysis for the presence of phytocomponents. To evaluate its effect on spatial learning, passive-avoidance test–step through (PAT-ST), Y-maze and Morris water maze (MWM) tests were carried out. Open-field (OFT) and elevated plus maze (EPM) tests were employed to explore the anti-anxiety potential of FB while a forced swimming test (FST) was utilized to assess its anti-depressant prospective. FB doses of 100, 200 and 300 mg/kg with positive and negative controls given to Sprague Dawley (SD) rats. Results: phytochemical studies showed the presence of various phytoconstituents including alkaloids, flavonoids, terpenes, phenolics and anthraquinones. The presence of synephrine, aspargine, glucose, fructose and fatty acids was revealed by GC–MS analysis. FB administration led to significant improved memory retention when evaluated through passive avoidance (p < 0.05), Y-maze (p < 0.05) and Morris water maze (p < 0.05) tests in a scopolamine model of amnesic rats. When tested by open field and elevated plus maze tests, FB demonstrated anxiety-resolving characteristics (p < 0.05) as animals dared to stay in open areas more than a control group. Mobility time was increased and immobility time was reduced (p < 0.05–0.01) in rats treated with FB, unveiling the anti-depressant importance of F. benghalensis. Conclusion: methanolic extract of F. benghalensis bark furnished scientific proof behind folkloric claims of the memory improving, anxiety-reducing and depression-resolving characteristics of the plant. These activities might be possible due to interaction of its phytoconstituents with serotonergic, glutamatergic, cholinergic and GABAergic systems in the brain.

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Section: Introductionmentioning

confidence: 99%

Amelioration of Scopolamine-Induced Amnesic, Anxiolytic and Antidepressant Effects of Ficus benghalensis in Behavioral Experimental Models

Malik¹,

Javaid²,

Rasool³

et al. 2020

Medicina

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“…Extracts of various plant parts of F. benghalensis have been known for their anathematic, analgesic, anti-inflammatory, antioxidant, antidiabetic, immuno-modulatory, and antimicrobial activities since ancient times, and the prop root has been used for toothaches. The stem, leaf, bark, fruit, and sap extracts of F. benghalensis have been used as an ayurvedic medicines to cure various diseases like dysentery, teeth disorders, skin disorders like sores, piles, diarrhea, and rheumatism, and to boost the immune system (Nidhiya et al 2010;Kumar et al 2010;Panday and Rauniar 2016).…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of silver oxide nanoparticles and its antibacterial activity against dental pathogens

et al. 2017

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In the present study, the use of silver oxide nanoparticles (AgO NPs) synthesized using Ficus benghalensis prop root extract (FBPRE) as a reducing and stabilizing agent is reported and evaluated for its antibacterial activity against dental bacterial strains. The effects of pH, extract concentration, metal ion concentration, and contact time were studied to confirm the optimum production of AgO NPs. Our results suggest that, by increasing the extract concentration and the time frame, there will be a significant increase in the formation of nanoparticles. The UV-vis adsorption spectra show the absorbance peak in the range of 430 nm, and FTIR spectral peaks indicate that the phytochemicals in the extract are responsible for the formation of the nanoparticles. The HR-TEM image, SAED, and XRD pattern confirmed the morphology (spherical), silver oxide 42.7 nm and silver 51.4 nm, and crystalline nature of the obtained nanoparticles, respectively. The blend of FBPRE and AgO NPs showed excellent antibacterial activities against the two-dental bacteria Streptococcus mutans and Lactobacilli sp. The study results suggest that the blend of synthesized AgO NPS and FBPRE will be useful in tooth paste as a germicidal agent after extensive investigation with animal models.

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“…In addition, the group effect on repeatedly measured behavioral parameters were tested using Repeated Measurement ANOVA [SPSS (United States)]. Non-parametric tests were chosen because a normal distribution (Shapiro-Wilk test) could not always be assumed (Sajikumar et al, 2007; Salkovic-Petrisic et al, 2015; Panday and Rauniar, 2016). P -value with <0.05 was considered to indicate a statistically significant difference between two groups and presented in the text.…”

Section: Methodsmentioning

confidence: 99%

Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice

Jing

Liu

et al. 2019

Front. Cell. Neurosci.

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The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellular Klotho form can be expressed and secreted. Inactivation of α-Klotho leads to a phenotype that resembles accelerated aging, as the expression level of the α-Klotho protein in the hippocampal formation of mice decreases with age. Here, we show that intrahippocampal viral expression of secreted human α-Klotho alters social behavior and memory formation. Interestingly, overexpression of secreted human α-Klotho in the CA1 changed the nest-building behavior and improved object recognition, object location and passive avoidance memory. Moreover, α-Klotho overexpression increased hippocampal synaptic transmission in response to standardized stimulation strengths, altered paired-pulse facilitation of synaptic transmission, and enhanced activity-dependent synaptic plasticity. These results indicate that memory formation benefits from an augmented level of secreted α-Klotho.

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Effect of root-extracts of Ficus benghalensis (Banyan) in memory, anxiety, muscle co-ordination and seizure in animal models

Cited by 19 publications

References 31 publications

Amelioration of Scopolamine-Induced Amnesic, Anxiolytic and Antidepressant Effects of Ficus benghalensis in Behavioral Experimental Models

Amelioration of Scopolamine-Induced Amnesic, Anxiolytic and Antidepressant Effects of Ficus benghalensis in Behavioral Experimental Models

Green synthesis of silver oxide nanoparticles and its antibacterial activity against dental pathogens

Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice

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