Effect of rosemary (<i>Rosmarinus officinalis</i>) extracts on the oxidative stability and sensory acceptability of soybean oil

Dias, Liara Silva; Menis, Michele Eliza Cortazzo; Jorge, Neuza

doi:10.1002/jsfa.6914

Cited by 24 publications

(21 citation statements)

References 27 publications

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“…Rosemary ( Rosmarinus officinalis , Lamiaceae) has been used in the food industry as a flavouring agent and to provide a major source of natural antioxidants 14 . Carnosic acid (CA), a naturally polyphenolic diterpene derived from the rosemary plant, has a wide array of pharmacological and biological activities.…”

Section: Introductionmentioning

confidence: 99%

Carnosic acid prevents dextran sulfate sodium-induced acute colitis associated with the regulation of the Keap1/Nrf2 pathway

Neng

Xia

Shao

et al. 2017

Sci Rep

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Crohn’s disease and ulcerative colitis are inflammatory bowel diseases (IBDs) with high prevalence in humans. Carnosic acid (CA) has been reported to possess antioxidative properties; however, its role in IBDs has not been determined. In the present study, we found that CA significantly prevented the loss of body weight and shortening of colon length in acute colitis induced by dextran sodium sulfate (DSS). Pronounced infiltration of immune cells and a loss of crypt architecture and goblet cells were ameliorated by CA. CA significantly decreased the activity of MPO and infiltration of F4/80+ macrophages in the colon. DSS-induced pro-inflammatory cytokine mRNA and protein levels in the colon were also attenuated by CA. CA decreased the activation of p65 and c-Jun signalling. CA inhibited DSS-induced NLRP3 inflammasome activation by reducing caspase 1 activity. In addition, CA increased the level of Nrf2 and prevented the degradation of Nrf2 via ubiquitination by blocking the interaction between Cullin3 and Keap1, which resulted in the decrease of Nrf2 target genes. Finally, GSH levels and SOD activity were increased after CA treatment, while MDA and iNOS levels were significantly reduced. Taken together, our data showed that CA may be useful as a potential therapeutic candidate for IBDs.

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Section: Introductionmentioning

confidence: 99%

Carnosic acid prevents dextran sulfate sodium-induced acute colitis associated with the regulation of the Keap1/Nrf2 pathway

Neng

Xia

Shao

et al. 2017

Sci Rep

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“…The accelerated storage test was used to evaluate the antioxidative efficiency of the added compounds. For this test, the method described by Dias et al . was used.…”

Section: Methodsmentioning

confidence: 99%

“…Rosemary extracts from Rosmarinus officinalis L. have been demonstrated in several comparison tests to be as effective as other antioxidants that are commonly used for food conservation . Rosemary extract is regarded as an important antioxidant against oil deterioration during frying operations . Its activity is especially related to the presence of phenolic diterpenes, carnosol and carnosic acid .…”

Section: Introductionmentioning

confidence: 91%

Combined effect of carnosol, rosmarinic acid and thymol on the oxidative stability of soybean oil using a simplex centroid mixture design

et al. 2017

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Results showed that bioactive compounds are effective in maintaining oxidative stability of soybean oil. However, the binary interaction of rosmarinic acid and thymol caused a reduction in antioxidant activity and oxidative stability of soybean oil. Optimum conditions for maximum antioxidant activity and oxidative stability were found to be an equal ternary mixture of carnosol, rosmarinic acid and thymol. © 2016 Society of Chemical Industry.

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“…Estudo realizado por Oliveira et al 31 Diante disso, é possível encontrar na literatura estudos que relatam algumas atividades farmacológicas de R. officinalis, como efeito antimicrobiano 32 , antibacteriano 33 , antifúngico 27,15 , antimicobacteriano 34 , anti-inflamatório 35,15 , antioxidante 36,37,32 , antimutagênico 38 , neuroprotetivo 39,40 , cardioprotetor 41 , modulador de estresse oxidativo 42,43 e DNA-protetivo 44 .…”

Section: O Constituintes Químicos Rosmarinus Officinalis Lunclassified

Rosmarinus officinalis L.: propriedades farmacológicas relacionadas à Odontologia

Medeiros¹,

Cruz²,

Oliveira³

et al. 2020

Arch Health Invest

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Introdução: Pesquisas na área de fitoterapia têm provado ser um método alternativo e eficaz contra diferentes agravos à condição de saúde humana, por isso, contribuições dela em diferentes áreas, como na Odontologia, tem grande importância como uma alternativa com menos efeitos colaterais comparados aos medicamentos sinteticamente fabricados, uma vez que as plantas medicinais têm demonstrado elevado poder de cura em estado natural. Objetivo: O presente trabalho objetivou apresentar uma revisão de literatura da espécie vegetal R. officinalis L. (Alecrim) em busca por novas possibilidades terapêuticas para a área da saúde, com ênfase na saúde bucal. Metodologia: O estudo trata-se de uma revisão bibliográfica narrativa, realizada no período de 18 de dezembro de 2017 à 28 de maio de 2018, utilizando artigos científicos em língua portuguesa, espanhola e inglesa, retirados das bases de dados Scielo, MedLine, Lilacs e Monografias. Discussão: Evidências científicas têm revelado que o extrato R. officinalis L possui grande poder antibacteriano, antifúngico, antiinflamatório e antioxidante, além de atuar efetivamente com reduções sob biofilmes polimicrobianos para área de Odontologia. Conclusão: Portanto, o efeito antimicrobiano produzido a partir de extratos do R. officinalis L tem sido positivo segundo relatos da literatura, todavia, mais pesquisas clínicos precisam ser realizados para enriquecer os atuais estudos, já que esta planta possui poder fitoterápico no tratamento de diversas injúrias bucais como gengivite e periodontite causadas como consequência da atividade bacteriana.

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Effect of rosemary (Rosmarinus officinalis) extracts on the oxidative stability and sensory acceptability of soybean oil

Abstract: The extracts are therefore potential sources of natural antioxidants and they would be well accepted by consumers if applied by the food industry to replace synthetic antioxidants.

Cited by 24 publications

References 27 publications

Carnosic acid prevents dextran sulfate sodium-induced acute colitis associated with the regulation of the Keap1/Nrf2 pathway

Carnosic acid prevents dextran sulfate sodium-induced acute colitis associated with the regulation of the Keap1/Nrf2 pathway

Combined effect of carnosol, rosmarinic acid and thymol on the oxidative stability of soybean oil using a simplex centroid mixture design

Rosmarinus officinalis L.: propriedades farmacológicas relacionadas à Odontologia

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