Effect of Rosmarinic acid on sertoli cells apoptosis and serum antioxidant levels in rats after exposure to electromagnetic fields

Hajhosseini, Laleh; Khaki, Arash; Merat, Ehsan; Ainehchi, Nava

doi:10.4314/ajtcam.v10i6.14

Cited by 29 publications

(27 citation statements)

References 12 publications

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“…In addition, the antioxidant effect of rosmarinic acid was verified in other studies . Rosmarinic acid borders to the functions of antioxidant vitamins and enzymes as a defense against oxidative stress . Besides their antioxidant effect, ellagic acid and rosmarinic acid hinder the expression of inflammatory cytokines …”

Section: Discussionmentioning

confidence: 99%

Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats

Georgy

Maher²

2017

J Biochem Mol Toxicol

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The anticancer drug doxorubicin causes testicular toxicity as an undesirable effect. The present study was undertaken to investigate the possible protection of ellagic acid and rosmarinic acid during doxorubicin administration. For this purpose eight groups of male Sprague-Dawley rats were used (n = 10), one group received vehicle served as control, and other groups received 5 mg/kg doxorubicin twice a week for 2 weeks for a cumulative dose of 20 mg/kg, ellagic acid (10 mg/kg/day, 14 consecutive days p.o.), rosmarinic acid (75 mg/kg/day, 14 consecutive days p.o.), ellagic acid and rosmarinic acid. The latter three regimens were given to control and doxorubicin-received rats. Doxorubicin decreased testicular relative weight, sperm count, motility, serum testosterone, testicular glycogen, and sialic acid with increased incidence of histopathological changes, oxidative stress, tumor necrosis factor-alpha, as well as cholinesterase activity. Conversely, ellagic and rosmarinic acid treatment ameliorated such damage, thus showing the possibility to use as an adjuvant during doxorubicin treatment.

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Section: Discussionmentioning

confidence: 99%

Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats

Georgy

Maher²

2017

J Biochem Mol Toxicol

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“…Different amounts of supplementation of RO prevents HS-induced decreases in growth performance and carcass traits of Japanese quail (Ç iftç i et al, 2013) and, also improves growth performance, egg traits, egg oxidative stability, and meat quality of Pharaoh quail reared in TN environmental conditions (Yesilbag et al, 2013). Different constituents (terpenoids, flavonoids, phenolic acids, volatile oils) of rosemary have been reported to function by decreasing oxidative stress in different tissues of mammals that is induced by different chemicals (Tanyıldızı et al, 2009;Singh et al, 2012;Raskovic et al, 2014) or that is produced as a result of exposure to electromagnetic field (Hajhosseini et al, 2013). RO (Melusova et al, 2014), rosmarinic acid (Hajhosseini et al, 2013), and terpenes (Singh et al, 2012) have DNA protective and anti-apoptotic features.…”

Section: Alleviating Effects Of Romentioning

confidence: 99%

Dietary rosemary oil alleviates heat stress-induced structural and functional damage through lipid peroxidation in the testes of growing Japanese quail

Türk

Çeribaşı

Şimşek

et al. 2016

Animal Reproduction Science

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Supplementation of natural antioxidants to diets of male poultry has been reported to be effective in reducing or completely eliminating heat stress (HS)-induced reproductive failures. In this study, the aim is to investigate whether rosemary oil (RO) has a protective effect on HS-induced damage in spermatozoa production, testicular histologic structures, apoptosis, and androgenic receptor (AR) through lipid peroxidation mechanisms in growing Japanese quail. Male chicks (n=90) at 15-days of age were assigned to two groups. The first group (n=45) was kept in a thermo-neutral (TN) room at 22°C for 24h/d. The second group (n=45) was kept in a room with a greater ambient temperature of 34°C for 8h/d (from 9:00 AM to 5:00 PM) and 22°C for 16h/d. Animals in each of these two groups were randomly assigned to three subgroups (RO groups: 0, 125, 250ppm), consisting of 15 chicks (six treatment groups in 2×3 factorial design). Each of subgroups was replicated three times with each replicate including five chicks. The HS treatment significantly reduced the testicular spermatogenic cell counts, amount of testicular Bcl-2 (anti-apoptotic marker) and amount of AR. In addition, it significantly increased testicular lipid peroxidation, Bax (apoptotic marker) immunopositive staining, and the Bax/Bcl-2 ratio in conjunction with some histopathologic damage. Dietary supplementation of RO to diets of quail where the HS treatment was imposed alleviated HS-induced almost all negative changes such as increased testicular lipid peroxidation, decreased numbers of spermatogenic cells, and decreased amounts of Bcl-2 and AR, increased ratio of Bax/Bcl-2 and some testicular histopathologic lesion. In conclusion, dietary supplementation of RO for growing male Japanese quail reared in HS environmental conditions alleviates the HS-induced structural and functional damage by providing a decrease in lipid peroxidation.

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“…Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and progesterone were assayed by two-site chemiluminescence (sandwich) immunoassay (16). Serum Total Antioxidant Capacity Measurement Serum TAC measurement is performed by means of a commercial kit (Randox Co., England).…”

Section: Fsh Lh and Estrogen Hormones Levels Measurementmentioning

confidence: 99%

Antioxidant Effects of Allium cepa and Cinnamon on Sex Hormones and Serum Antioxidant Capacity in Female Rats Exposed to Power Frequency Electric and Magnetic Fields

Mansouri¹,

Keshtkar²,

Khaki³

et al. 2016

IJWHR

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Effect of Rosmarinic acid on sertoli cells apoptosis and serum antioxidant levels in rats after exposure to electromagnetic fields

Cited by 29 publications

References 12 publications

Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats

Ellagic acid and rosmarinic acid attenuate doxorubicin-induced testicular injury in rats

Dietary rosemary oil alleviates heat stress-induced structural and functional damage through lipid peroxidation in the testes of growing Japanese quail

Antioxidant Effects of Allium cepa and Cinnamon on Sex Hormones and Serum Antioxidant Capacity in Female Rats Exposed to Power Frequency Electric and Magnetic Fields

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