Effect of routine iron supplementation on copper level and oxidative stress status in pregnant women

Derouiche, Samir; Dalal, Doudi; Noura, Atia

doi:10.4103/2305-0500.281075

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Copper and iron are redox-active transition metals and can participate in single electron reactions. High levels of maternal free copper catalyse formation of undesirable hydroxyl radicals via Fenton-like reactions [24,25,26]. These free radicals are thought to be involved in many physiological and pathological processes and are known to oxidatively modify DNA, lipids and proteins [24,23].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies had shown that during pregnancy, ATP7B plays a role in transporting copper from the placenta to maternal circulation, thus preventing fetal overload. Another reason for the increase copper in preeclampsia is due to blockade in the transfer of copper to fetus by the placenta [26,28,29]. If dysfunctional, excess copper remains in the fetus and placenta leading to oxidative damage resulting in fetal loss or may leads to oxidative damage [12,30].…”

Section: Discussionmentioning

confidence: 99%

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Serum Copper and Serum Zinc in Preeclampsia: Cause or Effect?

Sayyed¹,

Sontakke²

2020

IJBcRR

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Background: Preeclampsia is multisystem disorder. Despite its prevalence and severity, the pathophysiology of this multisystem disorder is poorly understood. In concern regarding the increasing number of preeclamptic cases and lack of data about the levels of trace elements in preeclampsia, a case-control study was conducted with aim to determine the trace elements like serum total copper and serum total zinc in preeclampsia. Aims: To estimate alterations in serum copper and serum zinc in preeclampsia and to compare them with normal pregnant women. Study Design: This is a case control study, carried out in the Department of Biochemistry, MIMER Medical College, Talegaon Dabhade, Pune. Methods: The present study consisted of 120 study participants. These were divided into two groups. Group I - normal pregnant women as control (n=60) and Group II - preeclamptic group (n=60). The serum levels of copper and zinc were determined by inductively coupled plasma atomic emission spectrometry (ICP- AES) technique at IIT Mumbai. Results: Analysis revealed that mean values of total serum copper and total serum zinc were 196.20 ± 25.9 and 77.15 ± 14.5 (µg/dl) respectively in control group. In preeclamptic group, the mean values of copper and zinc were 213.13± 38.6 and 76.23 ± 13.13 (µg/dl) respectively. Copper was significantly increased in preeclamptic group, while non-significant reduction in levels of zinc levels was observed when compared to control group. Conclusion: In the present study, significantly high serum copper was observed in preeclamptic patients. Presence of high copper levels may be related factor in the etiopathogenesis of preeclampsia. Estimation of trace elements like copper and zinc may help clinicians in early diagnosis and minimizing or delaying complications of preeclampsia, hence preventing harm to both mother & fetus.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum Copper and Serum Zinc in Preeclampsia: Cause or Effect?

Sayyed¹,

Sontakke²

2020

IJBcRR

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“…Multiple lung disease including apnea causes alveolar hypoventilation, vasoconstriction of the pulmonary artery and cyclic changes in hypoxemia contribute to increased production of reactive oxygen species (ROS) characteristic of the condition oxidative stress [8]. Oxidative stress is an important factor causing metabolic and physiological alterations and various diseases in the body [9]. COVID-19 attack triggers inflammatory reaction which releases pro-inflammatory cytokines characteristic of acute lung damage [10].…”

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confidence: 99%

Oxidative Stress Associated with SARS-Cov-2 (COVID-19) Increases the Severity of the Lung Disease - A Systematic Review

Derouiche¹

2020

J Infect Dis Epidemiol

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COVID-19 patients have a higher risk of developing inflammatory responses associated with serious and even fatal respiratory diseases. This review focuses on the relationship between oxidative stress and COVID-19. Coronaviruses are a family of common RNA viruses that can cause serious lower respiratory tract infections, followed by bronchitis and pneumonia. Pulmonary inflammation, fever and fibrosis are symptoms of COVID-19 mediated by cytokine pro-inflammatory. Oxidative stress affect repair mechanisms and the immune control system, which is one of the main events of the inflammatory response which allows us also to conclude that oxidative stress is a major factor increasing the severity of COVID-19 especially during chronic diseases associated with the fragility of the antioxidant system, suggesting to recommend antioxidants supplementation in therapeutic strategies against COVID-19.

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