Background: Preeclampsia is one of the most serious complications of pregnancy and one of the leading cause of maternal, prenatal morbidity and mortality. The present study was carried out to estimate serum high sensitive C- reactive protein in both mild and severe preeclampsia as an indicator of inflammation and to correlate Hs-CRP with blood pressure.Methods: A case control study was conducted in the Department of Biochemistry and Department of Obstetrics and Gynecology, MIMER Medical College and Bhausaheb Sardesai Rural Hospital Talegaon Dabhade, Pune. The study group include 50 cases of normal pregnant women, 43 clinically diagnosed cases of mild preeclampsia and 7 cases of severe preeclampsia in second and third trimester of pregnancy. 2 ml venous blood samples was collected from all the study participants for estimation of Hs-CRP by ultra-sensitive immunoturbidometric assay spin react method.Results: There was significant increase in the mean serum Hs-CRP levels in normal pregnant women and mild preeclamptic women (p<0.001). Serum Hs-CRP levels were significantly higher in severe preeclamspia than mild preeclamptic women (p<0.001). The degree of inflammation increases as HsCRP rises. Hence, present study shows that HsCRP levels increases as disease progresses from mild to severe condition. Significant positive correlations was found between Hs-CRP and Blood Pressure in preeclampsia.Conclusions: In preeclampsia there is an exaggeration of systemic inflammatory response that might induce reactive oxygen species which further induces endothelial dysfunction. This leads to clinical symptoms of hypertension and proteinuria in preeclampsia. Early detection might minimise systemic complications and maternal death due to preeclampsia. Hence, HsCRP may be used as an important indicator of severity of preeclampsia.

Introduction: Organ transplantation is the process of replacing diseased organs, parts of organs or tissues by healthy organs or tissues. The only way to increase organ donations is to educate the health care professionals and public about the importance of becoming an organ donor. One of the best ways is to educate the youngsters in the medical field. Aims: This study aims to determine the knowledge and awareness of 1 st MBBS students regarding organ donation. Material & Methods: Cross sectional questionnaire based study was conducted in Medical College of Western Maharashtra. Total 50 students, consisting both male (23) and female (27) students participated in the study. The aim was achieved by opting pre and post written test by predefined questionnaire, so as to check knowledge gained by the newly admitted 1 st MBBS students of MIMER Medical College before and after showing a short film "Hello Jindagi", followed by interactive discussion based on the organ donation. Data was analyzed in Microsoft Excel. Results & Conclusion: The results showed that knowledge gained after showing film was raised from 81% to 96%. So over all 15% gain in the knowledge was observed. "Paired t test" indicate statistically significant difference (P<0.049) between pre and post-test. The results of the study revealed that there exists a knowledge gap and lack of awareness among the medical students regarding organ donation and there is an urgent need for addressing this knowledge gap which will help in improving the organ donation rate in our country. By giving right knowledge and orientation medicos can be become future organ donors who can then easily motivate their patients to follow the path.

Background: Preeclampsia is multisystem disorder. Despite its prevalence and severity, the pathophysiology of this multisystem disorder is poorly understood. In concern regarding the increasing number of preeclamptic cases and lack of data about the levels of trace elements in preeclampsia, a case-control study was conducted with aim to determine the trace elements like serum total copper and serum total zinc in preeclampsia. Aims: To estimate alterations in serum copper and serum zinc in preeclampsia and to compare them with normal pregnant women. Study Design: This is a case control study, carried out in the Department of Biochemistry, MIMER Medical College, Talegaon Dabhade, Pune. Methods: The present study consisted of 120 study participants. These were divided into two groups. Group I - normal pregnant women as control (n=60) and Group II - preeclamptic group (n=60). The serum levels of copper and zinc were determined by inductively coupled plasma atomic emission spectrometry (ICP- AES) technique at IIT Mumbai. Results: Analysis revealed that mean values of total serum copper and total serum zinc were 196.20 ± 25.9 and 77.15 ± 14.5 (µg/dl) respectively in control group. In preeclamptic group, the mean values of copper and zinc were 213.13± 38.6 and 76.23 ± 13.13 (µg/dl) respectively. Copper was significantly increased in preeclamptic group, while non-significant reduction in levels of zinc levels was observed when compared to control group. Conclusion: In the present study, significantly high serum copper was observed in preeclamptic patients. Presence of high copper levels may be related factor in the etiopathogenesis of preeclampsia. Estimation of trace elements like copper and zinc may help clinicians in early diagnosis and minimizing or delaying complications of preeclampsia, hence preventing harm to both mother & fetus.

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Tobacco has been a prevalent cause of disease burden over India since decades. Gap in awareness among the population leads to use of tobacco, causing a number of deaths across India. The study aimed at assessing prevalence, attitude, knowledge gap harbouring in the urban population of Maharashtra. Effect of mass media was gauged along with the ability of people to avoid their addiction. A quantitative, online Google form based Questionnaire survey was conducted in a convenient sample of urban population across Maharashtra. 344 people participated following, the data was analysed using Microsoft Excel.29.1% (n=100) of the urban population were Tobacco users, most of which having Undergraduate/Postgraduate Educational qualification. 25% (n=61) of Non users didn’t know about the tobacco content in various products. Majority of Tobacco users were aware of the risk of Tobacco use causing heart attacks and also hold an opinion that smoking should be banned in public places. 38% (n=91) Tobacco users felt that there was a lack of impact of Tobacco use on social behaviour. People with different education levels consumed cigarettes/bidis the most. Higher educated class was found to have a higher conscious decision in Tobacco Usage. The need for Mass media enhancement was felt due to low impact on quitting behaviour. Tobacco was found to have a low impact on socializing, and it's true effects can be studied in future.