High sensitive C reactive protein as an inflammatory indicator in preeclampsia

Sayyed, Anjum; Pratinidhi, Shilpa A.

doi:10.18203/2320-6012.ijrms20203454

Cited by 7 publications

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“…Preeclampsia was found in higher percentage among primigravida compared to multigravida, whereas this association was not significant. These findings are similar to studies conducted by Sayyed AAK et al, and Prerna B et al [9,10] . The average levels of weight, average levels of systolic and diastolic blood pressure levels were significantly higher among preeclamptic group compared to the normal pregnancy group.…”

Section: Discussionsupporting

confidence: 92%

“…The similarity between the lesions of pre-eclampsia and atherosclerosis, together with the antifibrinolytic properties of Lp(a) has led to speculations of a common pathophysiological pathway [4] . The findings of Lp (a) in the present study is comparable with the studies conducted elsewhere [10,12] . In the present study, the average hsCRP levels were significantly among preeclamptic group (7.54±2.44 mg/dl) compared to normal pregnancy group (5.8±3.0mg/dl).…”

Section: Discussionsupporting

confidence: 91%

“…hsCRP is one of the markers of systemic inflammation and tissue damage and its levels are found to be high in women with PE. The hepatic synthesis of hs-CRP increases in response to inflammatory cytokines such as IL-10 and IL-6 which are responsible for inflammatory reactions and maternal endothelial activation in preeclampsia [9,10] . As there is evidence that there is an association between first trimester hsCRP levels and subsequent preeclampsia which supports the hypothesis that systemic inflammation is involved in the pathogenesis of preeclampsia, this biomarker has gained significance as it is easily available and is cost-effective test as compared to other markers of inflammation [4,9,10,12,13] .…”

Section: Discussionmentioning

confidence: 99%

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Association of lipoprotein (a) and high-sensitive C-reactive protein in preeclampsia

Savadi¹,

Anandpara²,

Rashmi³

2021

Int. J. Adv. Biochem. Res.

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Background: Preeclampsia is a hypertensive disorder associated with substantial perinatal morbidity and mortality. Neonates born to hypertensive mothers are at increased risk of prematurity and foetal growth restriction. Timely prediction and accurate diagnosis is the key to limiting the morbidity and mortality caused by preeclampsia. Early identification of PE using inflammatory biomarkers could reduce PE related comorbidities. Aim: To compare levels inflammatory markers: hsCRP and Lipoprotein(a) levels in preeclamptic pregnant women, with the levels of inflammatory markers among women with normal pregnancy at a tertiary care teaching hospital Material and Methods: This comparative cross-sectional study included 60 Preeclamptic women and 60 apparently healthy singleton pregnant women matched for gestational age and parity. Data was analyzed in SPSS V:16. To find association between inflammatory markers and blood pressure levels, statistical tests like chi-square, independent student t-test were applied. Results: Lp(a) and hsCRP levels were significantly higher among preeclamptic group compared to normal pregnancy group and these levels had moderate positive correlation with SBP (r=0.650) and DBP (0.627) among preeclamptic women. Conclusion: Increased levels of lipoprotein (a) and hsCRP are found in the present study, which are correlating with the progression of preeclampsia by causing endothelial dysfunction and inflammatory cascade. Also, earliest detection of Lp(a) and hsCRP in pregnancy could help to detect preeclampsia and to prevent its further complications.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Association of lipoprotein (a) and high-sensitive C-reactive protein in preeclampsia

Savadi¹,

Anandpara²,

Rashmi³

2021

Int. J. Adv. Biochem. Res.

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“…In the study preeclampsia was more common among the primigravida (65% of mild preeclampsia and 73% of severe preeclampsia group were primigravida). Similar results are found in the study conducted by Guhan VN et al Indumati V. et al 11,14 Alterations in serum electrolytes levels indicate the underlying physiological and pathological changes of pregnancy. In our study, hypernatremia and hypokalemia were found in both mild and severe preeclampsia with highest derangement seen in the severe preeclamptic group (highest sodium levels: 147±3.4 mmol/l and lowest potassium levels: 3.5±0.4mmol/l).…”

Section: Discussionsupporting

confidence: 88%

“…Some studies of preeclampsia have shown abnormality in the transport of sodium and potassium pump across the vascular smooth muscle cell membrane, which is normally responsible for maintenance of blood pressure. 11,14 In the present study, hypomagnesemia was found among both the mild and severe preeclamptic patients (mild PE: 1.5±0.5 mg/dl. ; severe PE: 1.4±0.3mg/dL).…”

Section: Discussionsupporting

confidence: 53%

Study of serum electrolytes, calcium and magnesium in preeclampsia at a tertiary hospital in central Karnataka

Savadi¹,

Archana²,

Nalwarkar³

et al. 2021

IJCBR

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Preeclampsia(PE) is a hypertensive disorder affecting about 5-14% of pregnancies worldwide and around 20% of high-risk pregnancies, resulting in maternal and perinatal morbidity and mortality. Imbalances in milieu of serum sodium and potassium, that are involved in functioning of vascular smooth muscles, leads to vasoconstriction and hypertension in PE. Calcium deficiency stimulates parathyroid hormone, leading to vasoconstriction. Magnesium regulates blood pressure by monitoring vascular tone and structure. There is scarcity of studies on these factors in PE in central Karnataka. To estimate levels of serum calcium, magnesium, sodium and potassium in preeclampsia. Hospital based cross-sectional study conducted from September, 2020 to February, 2021 at a Tertiary Teaching Hospital in Chitradurga. 60 diagnosed cases of preeclampsia and equal number of age, parity and gestational age matched women with singleton normal pregnancies, attending antenatal clinic or admitted and treated in obstetrics wards of the hospital were included in the study. Clinical examination and laboratory investigations to estimate biochemical parameters were conducted. Data was analyzed in SPSS V:20. Statistical tests like chi-square and One-way ANOVA test were applied to find the significance of associations. Hypernatremia, hypokalemia, hypomagnesemia and hypocalcemia were significant in preeclampsia compared to normal pregnancy group. In severe preeclamptia, highest levels of serum sodium and lowest levels of serum potassium, magnesium and calcium were found compared to the mild PE group. Timely estimation of serum electrolytes, calcium and magnesium through the course of pregnancy could help in early detection and prompt treatment of preeclampsia and also can prevent the adverse outcomes of pregnancies. Also, dietary restriction of sodium and dietary supplementation of calcium, magnesium and potassium rich foods to the pregnant women and calcium supplementation could reduce the risk of preeclampsia.

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Longitudinal profile of high‐sensitivity C‐reactive protein in women with pre‐eclampsia

Dangat

Wadhwani

Randhir

et al. 2023

American J Rep Immunol

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Problem: C-reactive protein (CRP) is a marker for inflammation and its role as a possible biomarker for an early prediction of pre-eclampsia (PE) is unclear. The present study investigates the levels of high-sensitivity CRP (hs-CRP) longitudinally across pregnancy in women with PE and compares them to women without PE (non-PE). Method of Study: A total of 324 pregnant women [216 non-PE and 108 PE women]were included in this study. Maternal blood was taken at four different intervals (V1 = 11-14 weeks, V2 = 18-22 weeks, V3 = 26-28 weeks, and V4 = at delivery).Results: Maternal serum hs-CRP levels were higher at V1, V2, and V3 (p < .05 for all) in the PE group compared to the non-PE group. The hs-CRP levels were associated with maternal blood pressure throughout pregnancy. Maternal hs-CRP levels did not differ among early and late onset PE. Higher maternal hs-CRP levels were associated with the increased risk of PE in unadjusted model in early pregnancy. However, there was no significance after adjusting for confounding factors. Conclusions:Our findings suggest although the levels of hs-CRP were higher in PE in early pregnancy, they are not associated with an increased risk of PE.

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High sensitive C reactive protein as an inflammatory indicator in preeclampsia

Cited by 7 publications

References 0 publications

Association of lipoprotein (a) and high-sensitive C-reactive protein in preeclampsia

Association of lipoprotein (a) and high-sensitive C-reactive protein in preeclampsia

Study of serum electrolytes, calcium and magnesium in preeclampsia at a tertiary hospital in central Karnataka

Longitudinal profile of high‐sensitivity C‐reactive protein in women with pre‐eclampsia

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