Effect of Sacubitril/Valsartan on Exercise-Induced Lipid Metabolism in Patients With Obesity and Hypertension

Engeli, Stefan; Stinkens, Rudi; Heise, Tim; May, Marcus; Goossens, Gijs H.; Blaak, Ellen E.; Havekes, Bas; Jax, Thomas; Albrecht, Diego; Pal, Parasar; Tegtbur, Uwe; Haufe, Sven; Langenickel, Thomas; Jordan, Jens

doi:10.1161/hypertensionaha.117.10224

Cited by 36 publications

(23 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the response was not augmented on sacubitril/valsartan treatment. 68 The finding is in line with cellular studies suggesting that neprilysin in adipocytes does not control natriuretic peptide-mediated lipolysis. 69 Furthermore, sacubitril/valsartan treatment for 8 weeks did not alter the abdominal subcutaneous adipose tissue transcriptome and expression of proteins involved in lipolysis, natriuretic peptide signaling, and oxidative metabolism.…”

Section: Clinical Trials Evidencesupporting

confidence: 82%

Natriuretic Peptides in Cardiovascular and Metabolic Crosstalk

et al. 2018

Self Cite

View full text Add to dashboard Cite

Section: Clinical Trials Evidencesupporting

confidence: 82%

Natriuretic Peptides in Cardiovascular and Metabolic Crosstalk

et al. 2018

Self Cite

View full text Add to dashboard Cite

“…Abnormal levels of cholesterol, triacylglycerol, or free fatty acids (FFA) in blood or peripheral tissues are significant features of lipid metabolic disorders. Dysregulation of lipid metabolism has been verified as the main cause of many diseases, including obesity, nonalcoholic fatty liver disease (NAFLD), cardiovascular diseases, insulin resistance, hypertension, and atherosclerosis . Therefore, investigation of the maintenance of lipid metabolism homeostasis is of great significance for the prevention and therapy of metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders

Hou

Zhang

et al. 2019

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Pomegranate (Punica granatum Linn) is used in the prevention and treatment of metabolic syndrome in recent decades. Imbalances in lipid metabolism are profound features of metabolic disorders. In vivo and in vitro studies have shown that extracts of different pomegranate fractions (peels, flowers, juice, and seeds) regulate lipid metabolism in metabolic‐disorder‐associated diseases such as atherosclerosis, nonalcoholic fatty liver disease, and type 2 diabetes, helping to alleviate the development of diseases. Amelioration of oxidative stress and the inflammatory response is considered an important reason underlying the regulation of lipid metabolism by pomegranate extracts. Mitochondria, the major cellular site for lipid oxidation, are strongly associated with cellular oxidative and inflammatory status and are likely to be a target for pomegranate extract action. This review summarizes the main findings about the effects of different pomegranate fraction extracts on lipid metabolism in metabolic‐disorder‐associated diseases and analyses how pomegranate extracts achieve their effects. Furthermore, it also provides an important basis for the research and development of pomegranate‐related nutrients or drugs.

show abstract

“…46 Also, in a small cohort (n ¼ 39), sacubitril/valsartan did not alter energy expenditure compared to amlodipine. 47 This suggests that activation of browning in this population is not clinically relevant, but unfortunately, no data for CKD patients are available.…”

Section: Discussionmentioning

confidence: 98%

Accumulation of natriuretic peptides is associated with protein energy wasting and activation of browning in white adipose tissue in chronic kidney disease

Luce¹,

Barba²,

Mey³

et al. 2020

Kidney International

View full text Add to dashboard Cite

P rotein-energy wasting (PEW) and cachexia, a severe form of PEW, are associated with poor survival in chronic kidney disease (CKD) and may occur in 20% to 80% of hemodialysis (HD) patients. 1,2 However, the mechanisms involved in uremic PEW are complex and remain poorly understood. PEW is different from malnutrition as it cannot be overcome by nutritional supplementation. 3 To date, there are few, if any, effective therapies to improve PEW associated with CKD. 4 Whether there is an increase in resting energy expenditure (REE), and its role in PEW during CKD, remain topics of

show abstract

Effect of Sacubitril/Valsartan on Exercise-Induced Lipid Metabolism in Patients With Obesity and Hypertension

Abstract: Supplemental Digital Content is available in the text.

Cited by 36 publications

References 38 publications

Natriuretic Peptides in Cardiovascular and Metabolic Crosstalk

Natriuretic Peptides in Cardiovascular and Metabolic Crosstalk

Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders

Accumulation of natriuretic peptides is associated with protein energy wasting and activation of browning in white adipose tissue in chronic kidney disease

Contact Info

Product

Resources

About