Effect of safeners on damage of human erythrocytes treated with chloroacetamide herbicides

Bernasińska, Joanna; Duchnowicz, Piotr; Koter−Michalak, Maria; Koceva‐Chyła, Aneta

doi:10.1016/j.etap.2013.04.010

Cited by 22 publications

(19 citation statements)

References 61 publications

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“…Since Pre can cause serious harm to rice seedlings, it is not surprising that the rice seedlings suffered from severe oxidative stress caused by Pre, but the effect of Fen on the antioxidant systems in rice suggested that the defensive antioxidative properties are also one manner in which Fen protects rice from injury caused by Pre. In a previous study related to the effects of chloroacetamides and safeners (mefenpyr and dichlormid) on human blood cells, the safeners alone did not elicit any changes in oxidative stress but instead reduced the lipid peroxidation induced by the chloroacetamide herbicides [32]. This result, together with ours, suggests a role of safeners as antioxidants both in human blood cells and in rice ( Fig.…”

Section: Discussionsupporting

confidence: 85%

Effects of fenclorim on rice physiology, gene transcription and pretilachlor detoxification ability

Yao

Cai

et al. 2020

BMC Plant Biol

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Background: Fenclorim (Fen) can effectively protect rice from pretilachlor (Pre) injury, but its effects on rice have not been formally evaluated; thus, the Fen mode of action for alleviating the phytotoxicity caused by Pre in rice is not clear. This study aimed to examine the biochemical and physiological effects of Fen on rice and to determine the changes induced by Fen at the transcriptome level.Result: The chlorophyll content of rice plants was significantly affected by Pre but not by Fen. The activity of oxidative stress enzymes showed that Fen did not elicit any changes in oxidative stress; however, it reduced lipid peroxidation and oxidative damage induced by Pre. Fen did not affect the uptake of Pre but did affect its persistence in rice. In a transcriptome experiment, Fen upregulated genes in a detoxification pathway. Overall, 25 genes related to detoxification were identified, including P450, GST, and GT. Moreover, qRT-PCR analysis showed that four P450 genes, CYP71Y83, CYP71K14, CYP734A2 and CYP71D55, and two GST genes, GSTU16 and GSTF5, were upregulated by Fen and/or Pre. Conclusion: Our work indicates that Fen acts in antioxidative defense in addition to enhancing the metabolism of herbicides in rice.

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Section: Discussionsupporting

confidence: 85%

Effects of fenclorim on rice physiology, gene transcription and pretilachlor detoxification ability

Yao

Cai

et al. 2020

BMC Plant Biol

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“…Since Pre can cause serious harm to rice seedlings, it is not surprising that the rice seedlings suffered from severe oxidative stress caused by Pre, but the effect of Fen on the antioxidant systems in rice suggested that the antioxidative defending properties are also one mechanisms of Fen in protecting rice from injury caused by Pre. In a previous study related to the effects of chloroacetamides and safeners (mefenpyr and dichlormid) on human blood cells, it was reported that the safeners alone did not elicit any changes in oxidative stress but instead they reduced the lipid peroxidation induced by the chloroacetamide herbicides [31]. This result, together with ours, suggests a role of safeners as antioxidants both in human blood cells and in rice.…”

Section: Discussionsupporting

confidence: 84%

Effects of fenclorim on rice physiology, gene transcription and pretilachlor detoxification ability

Yao

Cai

et al. 2019

Preprint

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Background Fenclorim (Fen) can effectively protect rice from pretilachlor (Pre) injury, but its effects on rice have not been formally evaluated; thus, the Fen mode of action for alleviating the phytotoxicity caused by Pre in rice is not clear. This study aimed to examine the biochemical and physiological effects of Fen on rice and to determine the changes induced by Fen at the transcriptome level. Result The chlorophyll content of the rice plants was significantly affected by Pre but not by Fen. The impacts of the activity of oxidative stress enzymes showed that Fen did not elicit any changes in oxidative stress; however, it reduced lipid peroxidation and oxidative damage induced by Pre. Fen did not affect the uptake of Pre but did affect its persistence in rice. In a transcriptome study, Fen upregulated genes in the detoxification pathway. Overall, 25 genes related to detoxification were identified, including P450, GST, and GT. Moreover, qRT-PCR analysis showed that four P450 genes, including CYP71Y83, CYP71K14, CYP734A2 and CYP71D55, and two GST genes, GSTU16 and GSTF1, were upregulated by Fen and/or Pre. Conclusion Our work indicates that Fen can act as an antioxidation defender in addition to enhancing the metabolism of herbicides in rice.

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“…Chloroacetamide herbicides include six herbicides, propisochlor, acetochlor, pretilachlor, alachlor, metolachlor and butachlor (Bernasinska et al, 2013). The antibody exhibited high specificity to propisochlor, and the CRs to acetochlor, pretilachlor, alachlor, metolachlor and butachlor were 11.6%, 2.5%, 0.6%, 0.4% and less than 0.01%, respectively.…”

Section: Molecular Modeling For Specificitymentioning

confidence: 96%

“…The European Union set the relevant laws and regulations to fix the maximum residue limit (MRL) of propisochlor pesticide in soybean (MRL, 0.1 mg/kg), and single pesticide in drinking water (MRL, 0.1 mg/ kg) (Bach et al, 2016). The previous research showed that propisochlor could flow into water systems and become highly toxic to some aquatic organisms (Bernasinska, Duchnowicz, Koter-Michalak, & Koceva-Chyla, 2013;Rauch & Földényi, 2012;Sturve, Scarlet, Halling, Kreuger, & Macia, 2016;Tufi et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Rapid and homologous immunoassay for the detection of herbicide propisochlor in water

Liu

Wang

Zhou

et al. 2017

Food and Agricultural Immunology

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The herbicide propisochlor can be introduced into the water cycle via agricultural activities, thus possibly leading to harmful ecological effects. It is significant for the development of a rapid method for propisochlor analysis in water. In this work, a rapid homogeneous immunoassay based on fluorescence polarization immunoassay (FPIA) was firstly developed for the determination of propisochlor in pond water. The developed FPIA assay can be completed within only 14 min; the 50% inhibition concentration (IC 50 ) was 125.1 ng/mL and the limit of detection was 8.4 ng/mL. The recoveries of propisochlor in pond water ranged from 80.0% to 86.6%. A high performance liquid chromatography confirmation showed a good correlation with the developed FPIA (R 2 = 0.9748). The developed FPIA exhibited satisfactory rapidity, high sensitivity and excellent specificity, meeting the standards of the screening assay of propisochlor in pond water on site. The molecular modeling showed that the alkoxyalkyl of chloroacetamide herbicides exerted important effects on the herbicide-antibody binding.

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Effect of safeners on damage of human erythrocytes treated with chloroacetamide herbicides

Cited by 22 publications

References 61 publications

Effects of fenclorim on rice physiology, gene transcription and pretilachlor detoxification ability

Effects of fenclorim on rice physiology, gene transcription and pretilachlor detoxification ability

Effects of fenclorim on rice physiology, gene transcription and pretilachlor detoxification ability

Rapid and homologous immunoassay for the detection of herbicide propisochlor in water

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