Effect of salbutamol on smoking related cough

Mulrennan, Siobhan A.; Wright, Caroline; Thompson, Rachel H.; Goustas, P; Morice, Alyn H.

doi:10.1016/j.pupt.2004.01.002

Cited by 16 publications

(12 citation statements)

References 16 publications

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“…Furthermore, albuterol has been shown not to inhibit cough induced by capsaicin Smith et al, 1991) or citric acid (Pounsford et al, 1985) in normal volunteers. However, in smoking-related cough, albuterol afforded significant protection (Mulrennan et al, 2004).…”

Section: E B 2 -Agonistsmentioning

confidence: 96%

Antitussive Drugs—Past, Present, and Future

et al. 2014

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Section: E B 2 -Agonistsmentioning

confidence: 96%

Antitussive Drugs—Past, Present, and Future

et al. 2014

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“…In an attempt to obtain a model that has some of the elements of clinically relevant cough in normal subjects, smokers with cough have been recruited to clinical studies [162]. These subjects provide another end-point, i.e.…”

Section: Normal Volunteer Studies With Airway Inflammationmentioning

confidence: 99%

ERS guidelines on the assessment of cough

Morice¹,

Fontana²,

Belvisi³

et al. 2007

Eur Respir J

613

619

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“…Clinical studies conducted to date have not managed to clearly establish whether or not b 2 -agonists attenuate cough. Indeed, although some clinical studies in normal volunteers [2] and in chronic cough associated with allergic [3] or obstructive conditions [4][5][6][7] have found a beneficial effect of b 2 -agonists, other trials have not found efficacy [8,9]. This confusion may exist, in part, due to the subjective nature of symptom scoring in comparison with objective cough monitoring, which has only recently become available, and the fact that few double-blind randomised placebo-controlled studies have been performed with cough as a primary end-point.…”

mentioning

confidence: 99%

β₂-Agonists block tussive responses in guinea pigsviaan atypical cAMP-dependent pathway

Freund-Michel

Birrell²,

Giembycz³

et al. 2009

Eur Respir J

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b 2 -Adrenoceptor agonists are the most effective bronchodilators currently available, and are used for symptom management in asthmatics. However, whether b 2 -agonists are also antitussive is controversial. Identifying an antitussive role for b 2 -agonists and dissecting the possible mechanism of action may help to explain the inconsistencies in the clinical literature and lead to the development of novel therapeutic agents. The aim of the present study was to determine whether or not b 2 -agonists attenuate the tussive response in guinea pig and human models, and, if so, to identify the mechanism(s) involved.Depolarisation of vagal sensory nerves (human and guinea pig) was assessed as an indicator of sensory nerve activity. Cough was measured in a conscious guinea pig model.A b 2 -agonist, terbutaline, dose-dependently inhibited the cough response to tussive agents in conscious guinea pigs. Terbutaline and another b 2 -agonist, fenoterol, blocked sensory nerve activation in vitro. Using these mechanistic models, it was established that b 2 -agonists suppress the tussive response via a nonclassical cyclic adenosine monosphosphate-dependent pathway that involves the activation of protein kinase G and, subsequently, the opening of largeconductance calcium-activated potassium channels.In conclusion, b 2 -adrenoceptor agonists are antitussive, and this property occurs due to a direct inhibition of sensory nerve activation. These findings may help to explain the confusion that exists in the clinical literature, and could be exploited to identify novel therapies for the treatment of cough, which is a significant unmet medical need.

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Effect of salbutamol on smoking related cough

Cited by 16 publications

References 16 publications

Antitussive Drugs—Past, Present, and Future

Antitussive Drugs—Past, Present, and Future

ERS guidelines on the assessment of cough

β₂-Agonists block tussive responses in guinea pigsviaan atypical cAMP-dependent pathway

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Effect of salbutamol on smoking related cough

Cited by 16 publications

References 16 publications

Antitussive Drugs—Past, Present, and Future

Antitussive Drugs—Past, Present, and Future

ERS guidelines on the assessment of cough

β2-Agonists block tussive responses in guinea pigsviaan atypical cAMP-dependent pathway

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Product

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β₂-Agonists block tussive responses in guinea pigsviaan atypical cAMP-dependent pathway