Effect of salinity and pH on the calibration of the extraction of pharmaceuticals from water by PASSIL

Męczykowska, Hanna; Stepnowski, Piotr; Caban, Magda

doi:10.1016/j.talanta.2017.11.012

Cited by 15 publications

(5 citation statements)

References 32 publications

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“…Also, the salting-out effect of NaCl added to the headspace was higher for non-polar compounds, while lower for polar compounds, like alcohols and phenols [25]. In the case of the use of an ionic liquid for the passive sampling of pharmaceuticals, an increase in the salt content decreases the sampling rates [26]. In the study presented here, the results show that salinity can have an impact on the POCIS passive extraction process only for sulfonamides.…”

Section: The Limitation Of the Study And Comparison With Other Studiesmentioning

confidence: 99%

Salinity and pH as factors affecting the passive sampling and extraction of pharmaceuticals from water

Lis

Stepnowski

Caban

2019

J of Separation Science

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Passive sampling is an attractive technique for the long‐term monitoring of pharmaceuticals in the water environment. The reliability of the received results depends on the properly performed calibration, namely the determination of analyte sampling rates. This step can be the source of a systematic error, as the sampling rate values are dependent on the water donor phase parameters. This is especially important for pharmaceuticals, since their chemical characteristics and ionic form change with pH. In this study, the cross‐effect of pH (3, 7, and 9) and salinity (0, 7, and 35 practical salinity unit, using artificial sea water) on the passive sampling of 21 pharmaceuticals (antiparasitics, beta‐blockers, non‐steroidal anti‐inflammatory drugs, sulfonamides) was tested. The primarily determined parameter was the sampling rate. In addition, the extraction efficiency, partitioning coefficient, and the concentration of the analytes on the sorbent were calculated. Generally, for the non‐steroidal anti‐inflammatory drugs, beta‐blockers, and antiparasitics, the change both in pH and salinity had a negligible impact on the mentioned experimental parameters. In contrast, the extraction of sulfonamides was impacted by both pH and salinity, while lipophilicity was not a decisive parameter.

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Section: The Limitation Of the Study And Comparison With Other Studiesmentioning

confidence: 99%

Salinity and pH as factors affecting the passive sampling and extraction of pharmaceuticals from water

Lis

Stepnowski

Caban

2019

J of Separation Science

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“…The calculated time-weighted average concentration for most analytes was consistent with that obtained from active sampling. The obtained results contributed to the creation of further studies on the development of POCIS-like samplers with ionic liquids (Męczykowska et al 2017b(Męczykowska et al , 2018(Męczykowska et al , 2019.…”

Section: Innovative Sorbentsmentioning

confidence: 76%

“…There are four limiting layers: the receiving phase, membranes, possible biotic contamination of the membrane and the aqueous boundary layer (Ibrahim et al 2013;Vallejo et al 2013;Berho et al 2017). In addition, the R s values may also depend on environmental conditions such as water salinity (Togola and Budzinski 2007;Bayen et al 2014;Męczykowska et al 2018), pH of the donor phase (Li et al 2011(Li et al , 2016aLis et al 2019), temperature (Ibrahim et al 2013;Yabuki et al 2016) and dissolved organic matter concentration (Li et al 2011;Ibrahim et al 2013). For this reason, many scientists propose to use performance reference compounds to make the obtained R s values more reliable.…”

Section: Calibration Of Passive Samplersmentioning

confidence: 99%

Pollutant analysis using passive samplers: principles, sorbents, calibration and applications. A review

2020

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Passive techniques are a constantly evolving method of monitoring water pollution, allowing the simultaneous sampling and concentration of selected chemical compounds. The most popular aqueous passive samplers are those in which sorbents are used as receiving phases, including: the Polar Organic Chemical Integrative Sampler (POCIS). Originally, POCIS contained the copolymer poly(divinylbenzene)-coN -vinylpyrrolidone, which allowed the collection of analytes with 0 ≤ log K ow ≤ 5, The limitation of the use of conventional samplers for sampling water pollutants only with a specific polarity has resulted in the fact that innovative sorbents are used more and more in POCIS-like samplers. In recent years, application of several innovative sorbents in POCIS-like samplers, for example: mixed-mode ion exchange polymeric sorbents, ionic liquids, molecularly imprinted polymers and carbon nanotubes has been described. This is the first review in which the usability of classical and innovative sorbents used in passive techniques principles has been collected and compared, and it has been shown that the type of sorbent can significantly affect the efficiency of sampling pollutants in the aquatic environment. The major points are the following: 1) principle of operation, of passive samplers, 2) characteristics of POCIS and sorbents used as receiving phases, 3) sampler calibration methods and environmental factors affecting their operation, 4) a detailed description of the application possibilities of conventional and innovative sorbents used in POCIS-like samplers. This review shows the growing number of works on the use of innovative sorption materials to overcome limitation of originally designed POCIS, and the published results, allow us to conclude that the type of sorbent may be a key factor in increasing the applicability of POCIS-like samplers.

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“…However, considering the topic of ILs in drug determination, it should be highlighted that these works mainly focus on explaining the function of The authors suggest that this situation results from the presence of β-blockers in a neutral or cationic form in the solution which cannot be adsorbed on the membrane surface to large [P 6,6,6,14 + ]IL cations. In turn, the increase in salinity caused a decrease in the efficiency of analyte extraction due to their competition with the ions of salts present in saline water [138]. Męczykowska et al [139] also assessed the effect of humic acids, temperature and mixing on the final extraction results of various pharmaceuticals using the PASSIL technique.…”

Section: Il Additives To the Mobile Phasementioning

confidence: 99%

“…Dependency between sampling rate (Rs) values and the salinity of the donor solution for selected sulfonamides and NSAIDs (the pKa values of target compounds are specified by the black dots). Figure adopted from the reference[138] with copyright permission.…”

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confidence: 99%

The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives

et al. 2020

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Recent years have seen the increased utilization of ionic liquids (ILs) in the development and optimization of analytical methods. Their unique and eco-friendly properties and the ability to modify their structure allows them to be useful both at the sample preparation stage and at the separation stage of the analytes. The use of ILs for the analysis of pharmaceuticals seems particularly interesting because of their systematic delivery to the environment. Nowadays, they are commonly detected in many countries at very low concentration levels. However, due to their specific physiological activity, pharmaceuticals are responsible for bioaccumulation and toxic effects in aquatic and terrestrial ecosystems as well as possibly upsetting the body’s equilibrium, leading to the dangerous phenomenon of drug resistance. This review will provide a comprehensive summary of the use of ILs in various sample preparation procedures and separation methods for the determination of pharmaceuticals in environmental and biological matrices based on liquid-based chromatography (LC, SFC, TLC), gas chromatography (GC) and electromigration techniques (e.g., capillary electrophoresis (CE)). Moreover, the advantages and disadvantages of ILs, which can appear during extraction and separation, will be presented and attention will be given to the criteria to be followed during the selection of ILs for specific applications.

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Effect of salinity and pH on the calibration of the extraction of pharmaceuticals from water by PASSIL

Cited by 15 publications

References 32 publications

Salinity and pH as factors affecting the passive sampling and extraction of pharmaceuticals from water

Salinity and pH as factors affecting the passive sampling and extraction of pharmaceuticals from water

Pollutant analysis using passive samplers: principles, sorbents, calibration and applications. A review

The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives

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