Effect of Salmeterol on Seasonal Changes in Airway Responsiveness and Exhaled Nitric Oxide in Pollen-Sensitive Asthmatic Subjects

Prieto, Luís; Gutiérrez, Valentina; Torres, V.; Uixera, Sonia; Marín, Julio

doi:10.1378/chest.122.3.798

Cited by 15 publications

(7 citation statements)

References 41 publications

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“…Acute inhalation of salmeterol, a long-acting beta 2 -agonist, also had no effect on eNO levels in eight of these subjects. Similarly, long-term salmeterol treatment in 14 atopic asthmatic patients had no effect on eNO levels (36). Moreover, salmeterol treatment did not attenuate the significant increase in eNO levels following natural exposure to allergens to which subjects were sensitized.…”

Section: Effects Of Bronchodilators On Enomentioning

confidence: 84%

“…For example, higher eNO concentrations were found in 26 atopic asthmatic patients with ongoing allergen exposure than in 12 unexposed atopic asthmatic patients (35). Moreover, eNO levels increased significantly during pollen season in 27 sensitized, atopic asthmatic patients (27.2 ppb to 66.1 ppb; P<0.001) (36). Interestingly, exposure to an allergen in the absence of specific sensitization does not lead to increased eNO levels.…”

Section: Effects Of Atopy On Enomentioning

confidence: 96%

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The Clinical Significance of Exhaled Nitric Oxide in Asthma

Pendharkar

Mehta²

2008

Canadian Respiratory Journal

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Asthma is an inflammatory disease of the airways, for which many therapeutic options are available. Guidelines for the management of asthma suggest a stepwise approach to pharmacotherapy based on assessment of asthma severity and control. However, the assessment of asthma control presently relies on surrogate measures, such as the frequency of symptoms or the frequency of use of short-acting beta2-adrenergic agonists. There is no simple, noninvasive technique for the assessment of severity of actual airway inflammation in asthma. The collection and analysis of nitric oxide (NO) levels in exhaled breath has recently become feasible in humans. Based on increased exhaled NO (eNO) levels in patients with asthma, eNO analysis has been proposed as a novel, noninvasive approach to the assessment and monitoring of airway inflammation, and as a basis for adjustments in asthma therapy. In the present paper, the relationship of elevated eNO levels in asthma with inflammatory, physiological and clinical markers of asthma in adults was reviewed. Use of eNO is a promising tool for diagnosing asthma, for monitoring asthma control and for guiding optimal anti-inflammatory asthma therapy. However, because of many unresolved questions, eNO cannot be recommended at present for routine clinical management of adults with asthma.

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Section: Effects Of Bronchodilators On Enomentioning

confidence: 84%

Section: Effects Of Atopy On Enomentioning

confidence: 96%

The Clinical Significance of Exhaled Nitric Oxide in Asthma

Pendharkar

Mehta²

2008

Canadian Respiratory Journal

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“…It is unlikely that the first test would have influenced the second test, because the challenge days were separated by at least 3 days. It has been demonstrated that in sensitized patients with asthma, airway responsiveness to methacholine or AMP increases during the pollen season [29]. Even in patients sensitized to perennial allergens, such as HDMs, the seasonal variability of bronchial responsiveness to methacholine has been reported [30].…”

Section: Discussionmentioning

confidence: 99%

Bronchial hyperresponsiveness to methacholine and adenosine 5′-monophosphate, and the presence and degree of atopy in young children with asthma

Suh¹,

Lee²,

Kim³

et al. 2011

Clinical &Amp; Experimental Allergy

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“…Thus, the effects caused by different baseline airway calibers on the subsequent determination of PC 20 could be eliminated. It has been demonstrated that in sensitized patients with asthma, airway responsiveness to methacholine or AMP increase during the pollen season (27). Even in patients sensitized to perennial allergens, such as house dust mites, the seasonal variability of bronchial responsiveness to methacholine was reported (28).…”

Section: Discussionmentioning

confidence: 99%

Methacholine and adenosine 5′‐monophosphate (AMP) responsiveness, and the presence and degree of atopy in children with asthma

Suh

Lee

Kim

et al. 2011

Pediatric Allergy Immunology

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The relationship between atopy and bronchial hyperresponsiveness (BHR), both key features of asthma, remains to be clarified. BHR is commonly evaluated by bronchial challenges using direct and indirect stimuli. The aim of this study was to investigate the degree of BHR to methacholine (direct stimulus) and adenosine 5'-monophosphate (AMP) (indirect stimulus) according to the presence and degree of atopy in children with asthma. We performed a retrospective analysis of data from 120 children presenting with a diagnosis of asthma. These children were characterized by skin-prick tests (SPTs), spirometry and bronchial challenges with methacholine and AMP. Atopy was defined by at least one positive reaction to SPTs, and its degree was measured using serum total IgE levels, number of positive SPTs and atopic scores (sum of graded wheal size). A provocative concentration causing a 20% decline in FEV(1) (PC(20) ) was determined for each challenge. Patients with atopy(n=94) had a significantly lower AMP PC(20) than non-atopic patients (n=26), whereas methacholine PC(20) was not different between the two groups. Among the patients with atopy, there was no association between methacholine PC(20) and any atopy parameter. In contrast, a significant association was found between AMP PC(20) and the degree of atopy reflected in serum total IgE, number of positive SPTs and atopic scores (anova trend test, p=0.002, 0.001, 0.003, respectively). AMP responsiveness was associated with the presence and degree of atopy, whereas such a relationship was not observed for methacholine responsiveness. These findings suggest that atopic status may be better reflected by bronchial responsiveness assessed by AMP than by methacholine.

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Effect of Salmeterol on Seasonal Changes in Airway Responsiveness and Exhaled Nitric Oxide in Pollen-Sensitive Asthmatic Subjects

Cited by 15 publications

References 41 publications

The Clinical Significance of Exhaled Nitric Oxide in Asthma

The Clinical Significance of Exhaled Nitric Oxide in Asthma

Bronchial hyperresponsiveness to methacholine and adenosine 5′-monophosphate, and the presence and degree of atopy in young children with asthma

Methacholine and adenosine 5′‐monophosphate (AMP) responsiveness, and the presence and degree of atopy in children with asthma

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