Effect of salts and surfactant and their doses on the gelation of extremely dilute solutions of methyl cellulose

Kundu, Patit Paban; Kundu, M

doi:10.1016/s0032-3861(00)00506-1

Cited by 79 publications

(66 citation statements)

References 13 publications

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“…11 Salts are known to influence the temperatureinduced phase transitions of aqueous solutions of thermosensitive polymers, such as MC, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers, triblock copolymers of poly(ethylene glycol) (PEG) and poly(D,L-lactide-co-glycolide) (PLGA), and copolymers of N-isopropylacrylamide. [12][13][14][15] Kim et al 13 investigated the effects of salt on the thermogelation behavior of PEG-PLGA-PEG. They found that salting-out salts, such as NaCl, decreased the gelation temperature through their water-structure formation properties.…”

Section: Introductionmentioning

confidence: 99%

“…23 New theories, such as specific ion binding, have also been proposed to explain the Hofmeister series. 14,15 Although the effects of salt on some gelation systems, including MC, have been investigated in our earlier studies, 12,24,25 few reports have been made on the effects of salt on the gelation of HPMC, even though HPMC has more applications in pharmaceutics. 2 Mitchell et al 26 showed that various salts that lower the cloud point of HPMC gels follow the order of the Hofmeister series.…”

Section: Introductionmentioning

confidence: 99%

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Effects of salts in the Hofmeister series and solvent isotopes on the gelation mechanisms for hydroxypropylmethylcellulose hydrogels

Liu

Joshi

Lam

2008

J of Applied Polymer Sci

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The effects of various inorganic salts and isotopic solvents on the thermal gelation behavior of hydroxypropylmethylcellulose (HPMC) in aqueous solutions were examined by micro-differential scanning calorimetry and rheological measurements. It was found that salting-out salts, such as NaCl, promoted the sol-gel transition of HPMC at a lower temperature. An analysis of solvent isotope effects on the changes in the temperature at maximum heat capacity (T m ) with salt concentration showed that interchain hydrogen bonding (hydrogen bonding between the hydroxyl groups of different HPMC chains) was involved in the sol-gel transition, and its strength depended on the temperature and salt concentration. It was demonstrated that the effectiveness of anionic species in changing the T m of the HPMC solutions was in the sequence of the Hofmeister series. Anionic species play a role in reducing T m by their influence on the structure of the water, which in turn affects interactions between hydroxyl groups and water molecules, interchain hydrogen bonding, and the strength of the water cages prohibiting hydrophobic association. Rheological and microcalorimetric results indicated that the change in the thermodynamics of gelation of the HPMC aqueous solution was determined by the salt types and concentration, and the effect of monovalent salts was found to be more cooperative than that of multivalent salts on the sol-gel transition.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of salts in the Hofmeister series and solvent isotopes on the gelation mechanisms for hydroxypropylmethylcellulose hydrogels

Liu

Joshi

Lam

2008

J of Applied Polymer Sci

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“…The gel strength depends on the degree of substitution and the molecular weight. 34,35) The particle size of IMC was decreased using a combination of MC addition and the bead mill method with the obtained IMC particles having a mean particle size of 190± 110 nm (Milled-IMC MC+ , mean± S.D. ).…”

Section: Gastric and Small Intestinal Ulcerogenic Response To Imc In mentioning

confidence: 99%

Effect of Solid Nanoparticle of Indomethacin on Therapy for Rheumatoid Arthritis in Adjuvant-Induced Arthritis Rat

Nagai

Ito

2014

Biological & Pharmaceutical Bulletin

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We designed new oral formulations containing indomethacin (IMC) solid nanoparticles, and investigate their usefulness by evaluating bioavailability and gastrointestinal lesions. The IMC solid nanoparticles were prepared using methylcellulose (MC), 2-hydroxypropyl-β-cyclodextrin (HPβCD), and the bead mill method, and high quality dispersions containing 1.0% IMC nanoparticles were prepared (IMC nano , particle size: 76 58 nm, means S.D.). The fate of serum IMC and the induction of paw edema in adjuvant-induced arthritis (AA) rats receiving low-doses IMC nano (0.4 mg/kg) were similar to those following the administration of a therapeutic dose of conventional IMC prepared with MC and HPβCD (conventional IMC, 2 mg/kg), and the bioavailability in 0.4 mg/kg IMC nano was 5.3-fold higher in comparison with that in 2 mg/kg conventional IMC. IMC-induced gastrointestinal lesions in AA rats administered IMC nano (8 mg/kg), in consideration of bioavailability, were significantly less than for conventional IMC (40 mg/kg). On the other hand, the toxicity caused by conventional IMC and IMC nano was similar in Caco-2 cells. It is possible that the oral administration of IMC solid nanoparticles will show increased effectiveness in treating RA without causing IMC-induced gastrointestinal lesions, since the bioavailability is higher than that of conventional IMC. An oral drug delivery system using drug nanoparticles may expand the usage of NSAIDs for therapy in the inflammatory field.

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“…[1][2][3][4][5][6][7][8][9][10] The gelation temperature of MC can be altered by adding different additives such as synthetic polymers and salts. [11][12][13][14] The salt reduces the gelation temperature of MC because of the salting-out effect. 15 NaCl is used for decreasing the gelation temperature of MC for the formation of drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Water State and Gelation of Methylcellulose Thermo-reversible Hydrogels by Thermal Analysis and NMR

et al. 2015

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Effect of salts and surfactant and their doses on the gelation of extremely dilute solutions of methyl cellulose

Cited by 79 publications

References 13 publications

Effects of salts in the Hofmeister series and solvent isotopes on the gelation mechanisms for hydroxypropylmethylcellulose hydrogels

Effects of salts in the Hofmeister series and solvent isotopes on the gelation mechanisms for hydroxypropylmethylcellulose hydrogels

Effect of Solid Nanoparticle of Indomethacin on Therapy for Rheumatoid Arthritis in Adjuvant-Induced Arthritis Rat

Analysis of Water State and Gelation of Methylcellulose Thermo-reversible Hydrogels by Thermal Analysis and NMR

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