Effect of Salvia leriifolia Benth. root extracts on ischemia-reperfusion in rat skeletal muscle

Hosseinzadeh, Hossein; Hosseini, Azar; Nassiri‐Asl, Marjan; Sadeghnia, Hamidreza

doi:10.1186/1472-6882-7-23

Cited by 23 publications

(10 citation statements)

References 40 publications

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“…It was shown that thymoquinone has a marked protective action against IR-induced gastric mucosal lesions (El-Abhar et al 2003). Moreover, it has protective effects against lipid peroxidation process during IRI in rat hippocampus (Hosseinzadeh et al 2007a).…”

Section: Discussionmentioning

confidence: 99%

Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia–reperfusion in rat skeletal muscle

Hosseinzadeh

Taiari

Nassiri‐Asl

2012

Naunyn-Schmiedeberg's Arch Pharmacol

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Thymoquinone have been shown to decrease ischemia-reperfusion injury (IRI) in some tissues such as gastric mucosa and brain. In this study, the effect of thymoquinone was evaluated on an animal model of IRI in the rat hind limb. Hind limb ischemia was induced by clamping the common femoral artery and vein. After 2 h ischemia, the clamp on the femoral vessels was taken off and the animal underwent 1 h reperfusion. Muscle injuries were evaluated by recording the electromyographic (EMG) potentials and performing some biochemical analysis including thiobarbituric acid reactive substances (TBARS), total sulfhydryl (SH) groups, and antioxidant capacity of muscle using ferric reducing ability of plasma (FRAP) assay. Ischemia was induced using free-flap surgery in skeletal muscle. Thymoquinone (20, 40 and 80 mg/kg) and normal saline (10 ml/kg) were administered intraperitoneally 1 h prior to reperfusion. The average peak-to-peak amplitude during ischemic reperfusion was significantly increased in thymoquinone groups in comparison with the control group. Following thymoquinone administration, the total SH contents and antioxidant capacity were elevated in muscle flap. The malondialdehyde (MDA) level was declined significantly in test groups. It is concluded that thymoquinone have some protective effects against the muscle tissue injury caused by lower limb ischemia-reperfusion.

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Section: Discussionmentioning

confidence: 99%

Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia–reperfusion in rat skeletal muscle

Hosseinzadeh

Taiari

Nassiri‐Asl

2012

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Studies about anti-ischemic effect of aqueous extracts of S. leriifolia leaf and seed in rat hippocampus show that neural cell injury in all regions of the hippocampus was reduced following pretreatment of animals with aqueous seed extract [27]. The results of another investigations indicated that pretreatment with aqueous and alcoholic extracts of S. leriifolia root significantly reduced the elevated concentration of lipid peroxides in rat hippocampus and muscle following ischemia-reperfusion injuries because of its antioxidant properties [27,28].…”

Section: Discussionmentioning

confidence: 99%

Effect of Persian Sage (Salvia rhytidia) Extract on Histomorphometric Changes of Cerebral Cortex and Hippocampus Following Ischemia-Reperfusion Injuries in Rat

Haghjoo

Tadjalli

2016

Zahedan J Res Med Sci

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Background: In the present study the effect of Salvia rhytidia extract on thickness of cerebral cortex and hippocampal regions following ischemia-reperfusion (IR) injuries is evaluated. Objectives: In the present study the extract of S. rhytidia, an endemic plant from south eastern of Iran, was used to prevent IR injuries induced in cerebral cortex and hippocampus of rats. Materials and Methods:In this cross-sectional study, 35 male healthy Wistar rats between 250 -350 g were randomly divided into 7 groups of 5 rats. Control group (A), ischemic groups (B, D, E, F, G) that left common carotid and left vertebral arteries were occluded for 10 minutes. Group D received S. rhytidia extract (3.2 mg/kg) and group E received silymarin (50 mg/kg), a chemical drug which is used for reducing oxidative stress, 2 hours after ischemia, whereas group F received S. rhytidia extract (3.2 mg/kg) and group G received silymarin (50 mg/kg), 72, 48, 24 and 0 hours before ischemia. Group B received no drug and sham group (C) received normal saline (NS) without ischemia. After 24 hours reperfusion, the brains of rats were prepared for histological studies and the data were analyzed using one way ANOVA and Duncan as posthoc test. Results: IR resulted in decrease in thickness of the cerebral cortex, CA1 and CA2 regions of the hippocampus in groups B, D and E compared to control (P < 0.05). But no significant decrease observed in thickness of the cerebral cortex and all hippocampal regions in groups C, F, G and CA3 and dentate gyrus regions of the hippocampus in groups B, D and E compared to control. Conclusions: This study showed that S. rhytidia extract can protect the forebrain from IR injuries due to antioxidative effect of the drug.

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“…Factors such as thrombosis and embolism and systemic blood reduction have pivotal role in induction of ischemia [1]. Cerebral ischemia leads to neurological disorders such as problems in movement and speech as well as neuropsychiatric defects such as cognitive dysfunction and apraxia, learning and spatial memory impairment [2]. High blood pressure, diabetes, smoking, alcohol drinking, dyslipidemia, hypercholesterolemia are main factors that increase risk of stroke [3].…”

Section: Introductionmentioning

confidence: 99%

Role of Plant Extracts in Treatment of Cerebral Ischemia

Hassanpour¹

2018

IPCM

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Stroke is a major cause of disability and the third leading cause of mortality in human. In recent decades, the incidence of stroke has significantly increased especially in developing countries. Approximately 20% of patients die within one month after the stroke. Moreover, patients who live more than six months are dependent others for their daily work. They have complications such as paralysis of a body part, impairment of memory, thinking, talking and moving. Due to the complex pathological process of ischemia, using a single agent in the treatment of ischemia does not seem ideal. Thus, studies for finding compounds and effective methods are growing. In recent years, attention to medicinal plants as a potential source in treatment of ischemia-reperfusion has increased. Here, association between medicinal plants with reduction of cerebral ischemia was reviewed. At the end, it was determined potential of medicinal plants in abrogation of cerebral ischemia through several different pathways. Thus, they can be a new source for production of medications against cerebral ischemia.

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Effect of Salvia leriifolia Benth. root extracts on ischemia-reperfusion in rat skeletal muscle

Abstract: Background: Salvia leriifolia have been shown to decrease ischemia-reperfusion (I/R) injury in brain tissues. In this study, the effects of S. leriifolia aqueous and ethanolic extracts were evaluated on an animal model of I/R injury in the rat hind limb.

Cited by 23 publications

References 40 publications

Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia–reperfusion in rat skeletal muscle

Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia–reperfusion in rat skeletal muscle

Effect of Persian Sage (Salvia rhytidia) Extract on Histomorphometric Changes of Cerebral Cortex and Hippocampus Following Ischemia-Reperfusion Injuries in Rat

Role of Plant Extracts in Treatment of Cerebral Ischemia

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