“…GP73, as a Golgi transmembrane protein, has been found to be expressed in various organs, such as the liver, stomach, and peripheral blood, to varying degrees, but its mechanism of action has not yet been fully defined. 19 Mao and Wang demonstrated that GP73 inhibited epithelial cell proliferation and differentiation; additionally, it can act as a negative regulator of host innate immunity, inhibiting the host immune response and increasing the risk of pathogen infection. 20 , 21 Therefore, GP73 may be crucial in pediatric BP, a disease largely caused by decreased immunocompetence and pathogen infection.…”