Effect of SARS-CoV-2 infection on fetal umbilical vein flow and cardiac function: a prospective study

Rizzo, Giuseppe; Mappa, Ilenia; Pietrolucci, Maria Elena; Lu, Jia Li Angela; Makatsarya, A.; D’Antonio, F.

doi:10.1515/jpm-2021-0657

Cited by 13 publications

(21 citation statements)

References 24 publications

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“…In the literature, there are few Doppler and echocardiographic studies evaluating the effects of SARS-CoV-2 infection on fetal circulation. [28][29][30] Rizzo et al assessed the fetal growth velocity and fetal hemodynamics with pulsatility index of uterine, umbilical, and middle cerebral arteries Doppler in pregnancies complicated and in those not complicated by SARS-CoV-2 infection. 28 They found that pregnancies complicated by SARS-CoV-2 infection are not at higher risk of developing fetal growth restriction through impaired placental function.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, there are few Doppler and echocardiographic studies evaluating the effects of SARS‐CoV‐2 infection on fetal circulation 28–30 . Rizzo et al.…”

Section: Discussionmentioning

confidence: 99%

“…Rizzo et al. also evaluated 54 pregnancies complicated and 108 not complicated by SARS‐CoV‐2 infection to explore whether SARS‐CoV‐2 can affect umbilical vein blood flow (UVBF) and fetal cardiac function 30 . The areas of atria and the sphericity index of both ventricles were selected among functional indices for assessing cardiac function in their study 30 .…”

Section: Discussionmentioning

confidence: 99%

“…also evaluated 54 pregnancies complicated and 108 not complicated by SARS‐CoV‐2 infection to explore whether SARS‐CoV‐2 can affect umbilical vein blood flow (UVBF) and fetal cardiac function 30 . The areas of atria and the sphericity index of both ventricles were selected among functional indices for assessing cardiac function in their study 30 . They found that there was no difference in fetal cardiac function, suggesting that SARS‐CoV‐2 infection in pregnancy is unlikely to affect fetal venous and cardiac hemodynamic 30 .…”

Section: Discussionmentioning

confidence: 99%

“…The areas of atria and the sphericity index of both ventricles were selected among functional indices for assessing cardiac function in their study 30 . They found that there was no difference in fetal cardiac function, suggesting that SARS‐CoV‐2 infection in pregnancy is unlikely to affect fetal venous and cardiac hemodynamic 30 . However, they included only mild disease of SARS‐CoV‐2 infection, none of them required hospitalization and they point out that further studies are needed to elucidate the influence of SARS‐CoV‐2 infection on fetal cardiac function by the severe spectrum of the disease 30 .…”

Section: Discussionmentioning

confidence: 99%

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Decreased fetal cardiac output in pregnant women with severe SARS‐Cov‐2 infection

et al. 2022

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Aim:We aimed to examine fetal cardiac output (CO) in patients who recovered from severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection. Materials:This prospective study included 48 pregnant women recovered from SARS-CoV-2 infection and 50 control cases. SARS-CoV-2 infection was diagnosed by polymerase chain reaction (PCR) test in patients. Fetal echocardiographic evaluations were performed at 24-37 weeks of gestation in pregnant women who recovered from the infection and control group. Results:The median value of ultrasound evaluation was 34 (2.6) weeks of gestation in the recovery from the SARS-CoV-2 infection (RSI) group, and 32 (7.6) weeks in the control group (p = .565). Left cardiac output (LCO) z score was significantly lower in the RSI group than the control group (p = .041). LCO and combine cardiac output (CCO) z score were significantly lower in the severe disease group than mild, moderate disease groups, and controls (p = .019 and p = .013). CCO (ml/min/kg) was decreased in the severe disease group when compared with control and mild disease groups (p = .044). Conclusion:In the present study, fetal cardiac output in pregnant women who recovered from SARS-CoV-2 infection was found to be significantly reduced in those with severe disease, while there was no significant difference in mild and moderate cases.Placental dysfunction and inflammatory cytokines might cause fetal cardiac changes.Further studies could be clarified on the impact of SARS-CoV-2 infection on fetal cardiac function.

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Section: Discussionmentioning

confidence: 99%

“…In the literature, there are few Doppler and echocardiographic studies evaluating the effects of SARS‐CoV‐2 infection on fetal circulation 28–30 . Rizzo et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Decreased fetal cardiac output in pregnant women with severe SARS‐Cov‐2 infection

et al. 2022

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Fetal brain biometry and cortical development after maternal SARS‐CoV‐2 infection in pregnancy: A prospective case–control study

Mappa

Pietrolucci

Maqina

et al. 2022

J of Clinical Ultrasound

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Objectives To assess cerebral growth and the development of fetal cortex using neurosonography in fetuses from pregnancies experiencing severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) according to infection timing. Methods Pregnancies with by SARS‐CoV‐2 during first and second trimesters were prospectively studied and matched with unaffected controls. Enclosed women underwent neurosonography at 30–34 weeks of gestation and corpus callosum (CC) and cerebellar vermis (CV) lengths measured. Further Sylvian fissure (SF), insula. Parieto‐occipital fissure (POF), and calcarine sulci fissures (CSF) depths were obtained. The ultrasonographic variables considered were normalized with fetal head size. Results One hundred and seventy four consecutive pregnancies experiencing SARS COV 2 infection (81 before 14 weeks and 93 later) and 131 not affected pregnancies were considered. General and pregnancy characteristics were similar between the three groups of women. No significant differences existed in CC and CV lengths across groups. Similarly, insula, SF, POF And CSF depth did not result changed in fetuses of affected mothers. Conclusions SARS‐CoV‐2 infection does nor resulted associate with differential fetal cortical development or brain growth in mildly symptomatic pregnant women. This information may be useful to reassure infected mothers on the health of their fetuses.

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Fetal cardiac function evaluation: A review

Vasciaveo

Zanzarelli

D’Antonio

2023

J of Clinical Ultrasound

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The aim of this review is to provide an up to date on the current use of fetal echocardiography in assessing the fetal cardiac function and its potential research and clinical applications. Despite classically is been used for prenatal diagnosis of fetal heart defects, assessment of fetal cardiac function has been recently proposed as a fundamental tool to assess pregnancies complicated by several disorders with long-term impact on post-natal cardiovascular health, such as placental insufficiency and fetal growth restriction. In this review we present anatomical and functional fetal cardiac development mechanisms and an overview of the currently available techniques for evaluating fetal heart function.

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Effect of SARS-CoV-2 infection on fetal umbilical vein flow and cardiac function: a prospective study

Cited by 13 publications

References 24 publications

Decreased fetal cardiac output in pregnant women with severe SARS‐Cov‐2 infection

Decreased fetal cardiac output in pregnant women with severe SARS‐Cov‐2 infection

Fetal brain biometry and cortical development after maternal SARS‐CoV‐2 infection in pregnancy: A prospective case–control study

Fetal cardiac function evaluation: A review

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