Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes

Yang, Jeong‐Yeh; Koo, Jeung-Hyun; Yoon, Ha‐Yong; Lee, Ju-Hyung; Park, Byung‐Hyun; Kim, Jong‐Suk; Myung, Sook Choi; Park, Jin-Woo

doi:10.3892/ijmm.20.4.527

Cited by 9 publications

(8 citation statements)

References 19 publications

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“…In addition, the relative opacity of the lenses incubated for 3 days of treatment of compound 1 was dosedependently reduced to 79.24 ± 7.90% (10 µM) and 72.87 ± 12.40% (25 µM), respectively. Scopoletin (1, 6-methoxy-7-hydroxy coumarin) has been isolated from many plant sources and has been shown various pharmacological effects such as anti-inflammatory, antioxidant, acetylcholinesterase inhibitory, antithyroid, antihyperglycemic, and lipoprogein lipase activities (Muschietti et al, 2001;Shaw et al, 2003;Rollinger et al, 2004;Sunanda and Anand, 2006;Yang et al, 2007). To the best of our knowledge, AGEs formation inhibitory activity of 1 and RLAR inhibitory activity of 4 were have not been reported previously.…”

Section: Resultsmentioning

confidence: 85%

Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis Ex Vivo

et al. 2010

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Five compounds previously known structures, scopoletin (1), northalifoline (2), stigmast-4-en-3-one (3), tiliroside (4), and oplopanone (5) were obtained from the flower buds of Magnolia fargesii using chromatographic separation methods. The structures of 1-5 were identified by the interpretation of their spectroscopic data including 1D- and 2D-NMR as well as by comparison with reported values. Three compounds 1-3 were found from M. fargesii for the first time in this study. All the isolates (1-5) were subjected to in vitro bioassays to evaluate the inhibitory activity on advanced glycation end products formation and rat lens aldose reductase (RLAR). Compound 1 showed a remarkable inhibitory activity on advanced glycation end products formation with IC(50) value of 2.93 μM (aminoguanidine: 961 μM), and showed a significant RLAR inhibitory activity with IC(50) value of 22.5 μM (3.3-tetramethyleneglutaric acid: 28.7 μM). Compound 4 exhibited potent inhibitory activity against RLAR (IC(50) = 14.9 μM). In the further experiment ex vivo, cataractogenesis of rat lenses induced with xylose was significantly inhibited by compound 1 treatment.

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Section: Resultsmentioning

confidence: 85%

Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis Ex Vivo

et al. 2010

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“…Phytosterols reduce the absorption of cholesterol in the gut and thereby lower blood cholesterol levels [ 36 ]. Scopoletin is a stimulator of lipoprotein lipase activity and protects against cardiovascular diseases [ 37 ]. Lignans improve immune responses [ 38 ].…”

Section: Phytochemical Composition Of Urtica Spmentioning

confidence: 99%

Urtica spp.: Ordinary Plants with Extraordinary Properties

2018

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Nettles (genus Urtica, family Urticaceae) are of considerable interest as preservatives in foods for both human and animal consumption. They have also been used for centuries in traditional medicine. This paper reviews the properties of nettles that make them suitable for wider applications in the food and pharmaceutical industries. Nettles contain a significant number of biologically-active compounds. For example, the leaves are rich sources of terpenoids, carotenoids and fatty acids, as well as of various essential amino acids, chlorophyll, vitamins, tannins, carbohydrates, sterols, polysaccharides, isolectins and minerals. Extracts from the aerial parts of nettles are rich sources of polyphenols, while the roots contain oleanol acid, sterols and steryl glycosides. Due to the variety of phytochemicals and their proportions they contain, nettles show noticeable activity against both Gram-positive and Gram-negative bacteria. These properties make nettles suitable for a range of possible applications, including functional food, dietary supplements and pharmacological formulations. Despite these benefits, the nettle is still an underestimated plant source. This paper provides a unique overview of the latest research on nettle plants focusing on the possibilities for transforming a common weed into a commercial plant with a wide range of applications. Special attention is paid to the antimicrobial activity of the active compounds in nettles and to possible uses of these valuable plants in food and feed formulations.

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“…Recent data have shown that TNFα infusion can induce systemic lipolysis in human subjects ( 40 ) . Treatment with TNFα in vitro increases glycerol release from rodent and human adipocytes, probably by inhibiting lipoprotein lipase activity ( 41 ) and down regulating the expression of perilipin, which then enables hormone-sensitive lipase to access the surface of lipid droplets ( 42 ) . TNFα-induced adipocyte lipolysis is the outcome of activation of the TNFα receptor 1-dependent pathway ( 43 , 44 ) , which involves the stimulation of extracellular signal-regulated kinase 1 and 2, mitogen-activated protein kinase, c-Jun N-terminal kinase and protein kinase A ( 45 , 46 ) .…”

Section: Potential Mediators Of Adipose Atrophymentioning

confidence: 99%

New insights into adipose tissue atrophy in cancer cachexia

Chen

Trayhurn

2009

Proc. Nutr. Soc.

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Profound loss of adipose and other tissues is a hallmark of cancer cachexia, a debilitating condition associated with increased morbidity and mortality. Fat loss cannot be attributable to reduced appetite alone as it precedes the onset of anorexia and is much more severe in experimental models of cachexia than in food restriction. Morphological examination has shown marked remodelling of adipose tissue in cancer cachexia. It is characterised by the tissue containing shrunken adipocytes with a major reduction in cell size and increased fibrosis in the tissue matrix. The ultrastructure of ‘slimmed’ adipocytes has revealed severe delipidation and modifications in cell membrane conformation. Although the molecular mechanisms remain to be established, evidence suggests that altered adipocyte metabolism may lead to adipose atrophy in cancer cachexia. Increased lipolysis appears to be a key factor underlying fat loss, while inhibition of adipocyte development and lipid deposition may also contribute. Both tumour and host-derived factors are implicated in adipose atrophy. Zinc-α2-glycoprotein (ZAG), which is overexpressed by certain malignant tumours, has been identified as a novel adipokine. ZAG transcripts and protein expression in adipose tissue are up regulated in cancer cachexia but reduced with adipose tissue expansion in obesity. Studies in vitro demonstrate that recombinant ZAG stimulates lipolysis. ZAG may therefore act locally, as well as systemically, to promote lipid mobilisation in cancer cachexia. Further elucidation of ZAG function in adipose tissue may lead to novel targets for preventing adipose atrophy in malignancy.

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Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes

Cited by 9 publications

References 19 publications

Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis Ex Vivo

Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis Ex Vivo

Urtica spp.: Ordinary Plants with Extraordinary Properties

New insights into adipose tissue atrophy in cancer cachexia

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