Effect of seasonal changes in Leydig cell number on the volume of smooth endoplasmic reticulum in Leydig cells and intratesticular testosterone content in stallions

Johnson, Linda Marlene; Thompson, Dixie L.

doi:10.1530/jrf.0.0810227

Cited by 55 publications

(33 citation statements)

References 13 publications

(30 reference statements)

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“…This relationship is not unique to the present study (Berndtson et ai, 1983;Johnson & Thompson, 1987 (Fig. 4) and per unit of seminiferous tubular length or basement membrane area (Fig.…”

Section: Discussionmentioning

confidence: 48%

“…Although hormone concentrations, rates of sperm production, Sertoli cell number, germ cell: Sertoli cell ratio and other related variables have been the subject of considerable research (Savard & Goldzieher, 1960;Lindner, 1961;Bedrak & Samuels, 1969;Swierstra et ai, 1974;Berndtson et ai, 1974Berndtson et ai, , 1979Berndtson et ai, , 1983Weisner & Kirkpatrick, 1975;Thompson et ai, 1977;Amann et ai, 1979;Johnson & Neaves, 1981;Squires et ai, 1981;Jones, 1983;Johnson & Thompson, 1983, 1987Jones & Berndtson, 1986), only a few of these variables have been subjected to com¬ parisons between the left and right testis within individual stallions. Such information is of basic value in characterizing normal reproductive biology of the stallion.…”

Section: Discussionmentioning

confidence: 99%

“…The causes of such variability are not fully understood, but seasonal (Berndtson et ai, 1983;Johnson & Thompson, 1987) and treatmentinduced alterations in testosterone secretion (Berndtson et ai, 1979;Squires et ai, 1981) have been associated with quantitative changes in spermatogenesis. Sperm production increases after puberty until at least 12 years of age (Amann et ai, 1979;Johnson & Neaves, 1981; Thompson, 1983;Jones & Berndtson, 1986), coincident with increasing concentrations of testosterone in peripheral blood (Johnson & Thompson, 1983).…”

Section: Introductionmentioning

confidence: 99%

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Relationship of intratesticular testosterone content of stallions to age, spermatogenesis, Sertoli cell distribution and germ cell-Sertoli cell ratios

Berndtson

Jones²

1989

Reproduction

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Summary. Testes were obtained from 47 1\p=n-\20-year-old stallions during the natural breeding season. Total testicular testosterone and testosterone/g testis increased with age (P < 0\m=.\005), and total testicular testosterone was associated with larger testis size (P < 0\m=.\05). Neither testosterone per gram nor per paired testes were related to total Sertoli cell number (P > 0\m=.\05), but greater testosterone per paired testes was associated with fewer Sertoli cells per unit of seminiferous tubule length (P < 0\m=.\005) or basement membrane area (P < 0\m=.\02) and with a higher number of germ cells supported per Sertoli cell (P < 0\m=.\05).Although values for testosterone per gram and per paired testes were unrelated (P > 0\m=.\10) to sperm production/g testis or to the yield of spermatids/ spermatogonium, testosterone per paired testes was positively related to sperm production per paired testes (P < 0\m=.\05). It is concluded that intratesticular testosterone increases with age, is related in a positive manner to quantitative rates of sperm production, and can account for some of the differences in sperm production among individual stallions within a single breeding season.

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“…This relationship is not unique to the present study (Berndtson et ai, 1983;Johnson & Thompson, 1987 (Fig. 4) and per unit of seminiferous tubular length or basement membrane area (Fig.…”

Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship of intratesticular testosterone content of stallions to age, spermatogenesis, Sertoli cell distribution and germ cell-Sertoli cell ratios

Berndtson

Jones²

1989

Reproduction

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“…44: [377][378][379][380][381][382][383] 1998) and sperm production has also been performed. The number of Leydig cells per testicular weight increases toward breeding season [7]. Daily sperm production shows the same tendency [5].…”

mentioning

confidence: 77%

“…Spermatozoa in testes were seen one year after birth. It takes approximately two years to attain sexual maturation [1], and thereafter the serum concentrations of testosterone, luteinizing hormone, and prolactin are higher in breeding season than in non-breeding season [2][3][4][5][6][7]. Morphometric analysis on some parameters, such as the number of Leydig and Sertoli cells,…”

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confidence: 99%

Morphological Studies on Testicular Development in the Horse.

Hondo

Murabayashi

Hoshiba

et al. 1998

Journal of Reproduction and Development

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Abstract. Developmental changes of horse testis were examined morphologically. Spermatogenesis initiated in the spring of 2-year-olds, and spermatogenic activity appeared to increase age dependently up to 9 years old. The characteristic feature of fetal testis is its large interstitial mass. The interstitial region revealed no proportionate change during the fetal period, but gradually decreased with age-dependency from birth to 9 years old. On the other hand, the area of seminiferous tubules showed no changes up to 1 year old. Most characteristic feature during development is the appearance/disappearance of pigmented cells. These cells first appeared in 3-day-old individuals and gradually increased in volume up to 1 year old (sampled in spring). The number of cells reached maximum at 2 months old, gradually decreased, and completely disappeared after 3 years old. The pigmented cells possessed large and small round bodies with various electron densities in the cytoplasm. Key words: Horse, Testis, Development.(J. Reprod. Dev. 44: [377][378][379][380][381][382][383] 1998) and sperm production has also been performed. The number of Leydig cells per testicular weight increases toward breeding season [7]. Daily sperm production shows the same tendency [5]. As for age-related changes, it is reported that serum gonadotropin levels and/or daily sperm production also increases with aging [5,8]. On the other hand, there is little information on the testicular morphology of horse testis during prenatal development. Cole et al. [9] found that the testis weight of the fetus reaches maximum (approximately 80 g) at 215 days of pregnancy. After that, its weight decreases to 10-20 g in newborn horses.easonal and/or age-related changes in reproduction of male horses have been described in S several reports. Spermatozoa in testes were seen one year after birth. It takes approximately two years to attain sexual maturation [1], and thereafter the serum concentrations of testosterone, luteinizing hormone, and prolactin are higher in breeding season than in non-breeding season [2][3][4][5][6][7]. Morphometric analysis on some parameters, such as the number of Leydig and Sertoli cells,

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Study of quinalphos (an environmental oestrogenic insecticide) formulation (Ekalux 25 E.C.)-induced damage of the testicular tissues and antioxidant defence systems in Sprague-Dawley albino rats

Debnath

Mandal

2000

J. Appl. Toxicol.

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The effect of quinalphos (O-O-diethyl-O-[quinoxalinyl-(2)-thionophosphate]), an environmental oestrogenic organophosphorus insecticide pollutant, was studied on Sprague-Dawley albino rats at doses of 250 and 500 microgram kg(-1) body wt. i.p. for 3, 8 and 15 days, respectively. After the treatment with quinalphos there was an increase in the lipid peroxides (as measured by manoldialdehyde production) and a decrease in the total lipid content for the testicular membrane. The effects were more pronounced at the low doses than at the higher doses, indicating that some physiological defence mechanisms were in operation at higher doses. The free-radical-scavenging enzymes (superoxide dismutase, catalase and glutathione peroxidase) showed significantly higher activity at high dose in comparison to their activities at low-dose treatment. Glutathione content was gradually reduced after quinalphos treatment, both in low and high doses. Histomorphohological studies showed that after the low-dose treatment shrinkage of the tubular diameter and testicular atrophy leading to degenerative changes in the germinal epithelium were observed. But at high dose, gradual recovery of various germ cell layers and significant expansion of seminiferous tubules of Sprague-Dawley rat testes were found; the latter is generally believed to be a useful index of testicular activity through the hypothalamo-hypophyseal-gonadal axis. The present study indicates that quinalphos caused damage and degeneration of the testicular tissues due to free-radical-mediated lipid peroxidation at low doses. We have also demonstrated that, in response to the damage, an endogenous antioxidant enzyme defence system became operative at the higher dose of treatment.

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Effect of seasonal changes in Leydig cell number on the volume of smooth endoplasmic reticulum in Leydig cells and intratesticular testosterone content in stallions

Cited by 55 publications

References 13 publications

Relationship of intratesticular testosterone content of stallions to age, spermatogenesis, Sertoli cell distribution and germ cell-Sertoli cell ratios

Relationship of intratesticular testosterone content of stallions to age, spermatogenesis, Sertoli cell distribution and germ cell-Sertoli cell ratios

Morphological Studies on Testicular Development in the Horse.

Study of quinalphos (an environmental oestrogenic insecticide) formulation (Ekalux 25 E.C.)-induced damage of the testicular tissues and antioxidant defence systems in Sprague-Dawley albino rats

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