Effect of selected plants on Haematological parameters of DMBA-induced breast cancer of albino rats

Abstract

The present study was aimed to investigate the effect of selected plants on haematological parameters of DMBA induced breast cancer of albino rats. Sixty-three female albino rats were used for the study and they were grouped into nine groups of seven animals each. Group I (control) was fed with normal feed. Groups II to IX, were orally administered 20mg DMBA/kg to induce tumour. Group II was untreated; Group III was treated with tamoxifen(6.6mg/kg). Groups IV-IX were treated with 500mg/kg Sorghum vulgare, 1000mg/kg Sorghum vulgare, 500mg/kg Eremomastax polysperma; 1000mg/kg Eremomastax polysperma, 500mg/kg Brillantaisia owariensis and 1000mg/kg Brillantaisia owariensis respectively. Treatment with the different aqueous concentrate demonstrated significant increase (p≤ 0.05) of haemoglobin, and packed cell volume levels of the treated groups when compared to the DMBA group. There was a decrease in Neutrophil, N/L, P/L and platelets level in the treated groups when compared to the DMBA group (though not significant, p≤ 0.05). The present study reveals that the plants might be able to reduce anaemia posed as a result of breast cancer.