Effect of semen quality on human sex ratio in in vitro fertilization and intracytoplasmic sperm injection: an analysis of 27,158 singleton infants born after fresh single-embryo transfer

Arikawa, Mikiko; Jwa, Seung Chik; Kuwahara, Akira; Irahara, Minoru; Saito, Hidekazu

doi:10.1016/j.fertnstert.2015.12.009

Cited by 17 publications

(12 citation statements)

References 49 publications

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“…However, we are unable to assess this with our data as NASS does not currently collect information on embryo quality or morphology. ICSI, as compared with conventional fertilization, was associated with a lower proportion of male infants, confirming findings of prior studies (16)(17)(18)(19)37). Although the reduced proportion of male infants could be related to a decreased percentage of Y-bearing sperm in patients undergoing ICSI, ICSI use in patients with normal sperm function is also associated with a reduced proportion of males (38).…”

Section: Discussionsupporting

confidence: 84%

“…Our data support this, as similar proportions of male infants were seen in cycles using ICSI with male factor infertility and cycles using ICSI in the absence of male factor infertility. It is possible that the decreased proportion of males after ICSI is iatrogenic in origin, with X chromosome-bearing spermatozoa more frequently selected for use due to differences in morphology (37,38). In contrast, transfer of two or more embryos was associated with a greater likelihood of female sex.…”

Section: Discussionmentioning

confidence: 99%

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Trends and correlates of the sex distribution among U.S. assisted reproductive technology births

Narvaez

Chang

Boulet

et al. 2019

Fertility and Sterility

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Objective: To assess national trends in the sex distribution of live-born infants in the assisted reproductive technology (ART) and general population and to identify factors correlated with offspring sex. Design: Retrospective cohort study. Setting: Fertility treatment centers. Patients: All live-born infants included in the National Vital Statistics System and resulting from ART cycles reported to the National ART Surveillance System during 2006-14. Interventions: Not applicable. Main Outcome Measure(s): Trends in the proportion of male infants in the general population and proportion of males from fresh ART cycles among all ART live-born infants and singletons after single ET. Result(s): There were 214,274 live-born infants resulting from fresh ART cycles; 53.5% (5,492/10,266) of infants resulting from PGD/ PGS cycles were male, as compared with 50.6% (103,228/204,008) in the non-PGD/PGS group. Among non-PGD/PGS cycles, blastocyst transfer was positively associated with male infants (adjusted risk ratio [aRR] ¼ 1.03; 95% confidence interval [CI], 1.02-1.04). Intracytoplasmic sperm injection was negatively associated with male infants (aRR ¼ 0.94; 95% CI, 0.93-0.95) and for singletons after single ET (aRR ¼ 0.93; 95% CI, 0.90-0.95), as was transfer of two embryos (aRR 0.98; 95% CI, 0.97-0.99) or three or more embryos (aRR ¼ 0.98; 95% CI, 0.96-0.99) among all live births from cycles without PGD/PGS use. Conclusion(s): The proportion of male live-born infants among ART population did not change during 2006-14, ranging from 50.5% to 51.2%. Factors such as blastocyst transfer, intracytoplasmic sperm injection use, embryo stage, and number of embryos transferred may be associated with infant sex; further investigation is needed to understand possible underlying causes. (Fertil Steril Ò 2019;112: 305-14. Ó2019 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Trends and correlates of the sex distribution among U.S. assisted reproductive technology births

Narvaez

Chang

Boulet

et al. 2019

Fertility and Sterility

View full text Add to dashboard Cite

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“…However, in humans, Bae et al ( 45 ) observed that the percentage of bicephalic sperm was significantly associated with the increase of born females. In the same way Arikawa et al ( 46 ), using IVF, observed that samples with low sperm motility (<40%) had a minor proportion of males compared to those samples with normal sperm motility. This variation in the sex ratio (less males) observed with low-quality semen could be associated with a lower proportion of Y-bearing sperm in the ejaculate, as suggested by Eisenberg et al ( 47 ) in humans.…”

Section: Discussionmentioning

confidence: 60%

Comparing the Effect of Different Antibiotics in Frozen-Thawed Ram Sperm: Is It Possible to Avoid Their Addition?

et al. 2021

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It is crucial to perform a deep study about the most extensively used antibiotics in sperm extenders. Most of the protocols and concentrations used in ram are direct extrapolations from other species. It is important to establish species-specific antibiotic treatments to optimize their use and if it is possible to reduce the quantity. Previews studies have assessed some aspects of sperm quality in vitro, but this study aimed to go further and assess the effect of three different antibiotic treatments, which are the most extensively used, not only in sperm quality or assessing the inhibitory effect on bacterial growth but also assessing these important parameters of productivity such as fertility, prolificacy, fecundity, and sex-ratio during a freeze-thaw process. Gentamicyn (G) treatment showed the worst results, not only concerning sperm quality but also in the reproductive trials exhibiting a toxical effect at the experiment concentration, and being the most powerful inhibiting bacterial growth. For its part, Lincomicyn-spectinomycin (LS) showed similar results inhibiting bacterial growth but it did not show a detrimental effect either in sperm quality or in reproductive parameters. Penicillin-streptomycin (PS) showed good results in the sperm quality and in the reproductive in vivo trials, but it showed a very poor effect inhibiting bacterial growth probably due to some kind of antibiotic resistance. According to our results, there is not a significant positive relationship between the higher bacterial inhibitory activity of LS and PS samples, and the sperm quality respect Control samples (without antibiotics). In the case of G, which exhibited the most effective as antibacterial, we observed a toxic effect on sperm quality that could be translated on productivity parameters. Our results suggest that the bacterial contamination control in frozen-thawed semen may be possible without the use of antibiotics, although the effects of longer periods of cooling storage and different temperatures of storage need to be further investigated for animal semen. At this point, a reflection about a drastic reduction in the use of antibiotic treatments in sperm cryopreservation is mandatory, since freezing conditions could keep sperm doses contamination within the levels recommended by regulatory health agencies.

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“…A previous retrospective cohort study reported that lower sperm motility significantly affected the sex ratio in IVF cycles (Arikawa, Jwa, Kuwahara, Irahara, & Saito, 2016). Although sperm progressive motility in the NSMR ≥4% group was significantly higher than that in the NSMR <4% group, there was no significant difference in the infant sex ratio between the two groups, consistent with the conclusion presented in the reported literature, which has shown that the NSMR did not significantly affect the sex ratio (Li et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

Chen

Liu

et al. 2020

Andrologia

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The present study assessed the influences of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional in vitro fertilisation cycles. This retrospective study analysed 427 and 2,728 cycles from the normal sperm morphology rate <4% and ≥4% group respectively. The clinical (total fertilisation failure, clinical pregnancy, implantation and abortion) and neonatal (sex, gestational age, preterm birth, birthweight, low birth weight, live births and birth defects of newborns) outcomes were compared. The rate of total fertilisation failure in the normal sperm morphology rate <4% group was significantly higher compared with that in the normal sperm morphology rate ≥4% group (2.8% versus 1.2%, p = .012). Total fertilisation failure was completely resolved by early rescue intracytoplasmic sperm injection. The clinical pregnancy, implantation and abortion rates were not significantly different between the two groups. Additionally, the sex, preterm birth, low birth weight, live births and birth defect rates, gestational age and birthweight of newborns were not significantly different between the two groups. Thus, normal sperm morphology rate <4% significantly increased the total fertilisation failure rate but did not affect the clinical or neonatal outcomes.

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Effect of semen quality on human sex ratio in in vitro fertilization and intracytoplasmic sperm injection: an analysis of 27,158 singleton infants born after fresh single-embryo transfer

Cited by 17 publications

References 49 publications

Trends and correlates of the sex distribution among U.S. assisted reproductive technology births

Trends and correlates of the sex distribution among U.S. assisted reproductive technology births

Comparing the Effect of Different Antibiotics in Frozen-Thawed Ram Sperm: Is It Possible to Avoid Their Addition?

Effects of the normal sperm morphology rate on the clinical and neonatal outcomes of conventional IVF cycles

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