Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice

Development of spray‐ and freeze‐dried high‐concentration sesamol emulsions and antioxidant evaluation in fibroblasts and UV‐exposed rat skin slices

“…6C). These results showing non-toxic effects to 3T3 cells of emulsions in the range 100-1,500 mg/mL (i.e., in the SEOH concentration range of 0.005-0.11 mM) are in good agreement with previous reports on free SEOH in lymphocytes [Prasad et al, 2005] and endothelial cells [Chen et al, 2005] or in experiments on rats injected with a SEOH bolus of 10-100 mg/kg yielding a blood concentration at least in the micromolar range [Hsu et al, 2006;Parihar et al, 2006] without any toxic effects.…”

“…In relation to a more general therapeutic purpose, the present studies were focused on developing stable sesamol-containing dry emulsions that retained high antioxidant properties. Sesamol (3,4-methylenedioxyphenol, SEOH) was selected as the active agent because of its known free radical scavenging [Joshi et al, 2005;Aboul-Enein et al, 2007] and anti-lipoperoxidant [Ghafoorunissa et al, 2004;Hsu et al, 2006] activities, and because it has demonstrated a great efficacy in simple ointment-based formulations for preventive topical application in the mouse exposed to phototoxic doses of UV light [Sharma and Kaur, 2006] or a protective ability after in vivo administration to g-irradiated mice [Parihar et al, 2006].…”

“…Since SEOH has absorption maxima at the UV-B region (280-320 mm), its protective usefulness against phototoxic UV doses [Sharma and Kaur, 2006] or girradiation [Prasad et al, 2005;Parihar et al, 2006] in biological models was recently reported. In our study, the observed increased efficiency of solid dosage forms of SEOH compared to liquid formulations may result from combined and/or synergistic effects involving a better contact of the o/w emulsion with the skin and the protection provided by the encapsulation against UV-induced free radical processes.…”

Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences

“…Sesamol also possesses strong anti-inflammatory activity. Sesamol (5-hydroxy-1,3-benzodioxole or 3,4-methylenedioxyphenol) is the major constituent of sesame seed oil (obtained from Sesamum indicum), which makes it more resistant to oxidative deterioration than other vegetable oils (Parihar et al 2006). The sesame seed contains sesaminol, sesamolin, and sesamol as lignan compounds (Budowski 1950;Fukuda et al 1994).…”

Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats

“…SM has been extensively studied in our laboratory for its in vitro and in vivo antioxidant and anti-clastogenic properties following its administration via i.p. route in rodents (Parihar et al, 2006). However, its potential for promoting healing has not yet been studied.…”