Effect of Sesamum indicum (Linn) Seeds Supplemented Diets on Blood Glucose, Lipid Profiles and Serum Levels of Enzymes in Alloxan Induced Diabetic Rats

Akanya, Helmina O.; Isa, U.; Adeyemi, H.R.Y.; Ossamulu, Ifeanyi Famous

doi:10.9734/jalsi/2015/15941

Cited by 5 publications

(7 citation statements)

References 12 publications

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“…Ashakumary et al, (1999) reported that, sesame oil also contains lignans that are known to complex cholesterol from the gut and prevent cholesterol absorption.While Akanya et al, (2015) reported that, reduction in cholesterol levels observed in diabetic groups which were treated with sesame may be due to the presence of saponins. Saponins have been reported to form complexes with cholesterol and bile acids and prevent them from being absorbed through the small intestine hence lowers the cholesterol level in the blood and liver.…”

Section: Resultsmentioning

confidence: 98%

“…In this respect, in 2009 Bellentani and Marino reported that, 10-35% of the adult population in the worldwide suffering from NAFLD. On the other hand, Alberti et al, (2005) decided that hypertension, insulin resistance, obesity and dyslipidemia occur during NAFLD. Aside from the gain of weight and also obesity, the dietary composition, types and the amount of fat induced the development of NAFLD, in this respect, Donnelly et al, (2005) reported that, feeding three day isoenergetic diet ( 31 ) Egyptian Journal for Specialized Studies -Vol (8) N (27) July 2020 containing 30% energy from fat increased the level of triglyceride by about 15% in the liver which derived from dietary fat.…”

Section: Introductionmentioning

confidence: 99%

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Effect of medium -fat diets containing flaxseed, sesame seeds and their oils on non-alcoholic fatty liver disease in rats.

Aziz

Khalil²,

Nageb³

et al. 2020

المجلة المصریة للدراسات المتخصصة

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containing flaxseed, sesame seeds and their oils on non-alcoholic fatty liver disease (NAFLD) in rats, from some nutritional and biochemical parameters, in addition to estimate the chemical composition and fatty acids of the two types of the tested seeds. Fifty-four adult male Albino rats (Sprague Dawley strain), were used in this study and divided into two main groups. The first main group (6 rats) fed on basal diet, as a control negative group. The second main group (48 rats) fed on high fat diet (HFD) for 6 weeks to induce non-alcoholic fatty liver disease, after confirmation rats were randomly assigned to eight equal subgroups: Subgroup (1): fed on high fat diet (HFD) and used as a control positive group (+ve)1. Subgroup (2): fed on medium fat diet (MFD) and used as a control positive group (+ve)2. Subgroup (3): fed on (MFD), replace (10% sheep tallow with 10% flax seeds oil). Subgroup (4): fed on (MFD), replace (10% sheep tallow with flax seeds which provided the diet with 10% oil). Subgroup (5): fed on (MFD), replace (10% sheep tallow with 10% sesame oil). Subgroup (6): fed on (MFD), replace (10% sheep tallow with sesame seeds which provided the diet with 10% oil). Subgroup (7): fed on (MFD), replace (10% sheep tallow with 5% flaxseeds oil and 5% sesame oil). Subgroup (8): fed on (MFD), replace (10% sheep tallow with sesame seeds which provided the diet with 5% oil and flax seeds which provided the diet with 5% oil). The experiment lasted for 4 weeks. The results indicated that, treating NAFLD rats with MFD containing (10% flaxseeds oil, flaxseeds which provided the diet with 10% oil, 10% sesame oil, sesame seeds which provided the diet with 10% oil, 10% (flaxseeds oil and sesame oil) and (sesame and flaxseeds which Samar El-Sayed Mohamed (30) http://ejos.journals.ekb.eg-Vol (8) N (27) July 2020 provided the diet with 10% oil) led to significant decrease in body weight gain %, organs weight%, peritoneal fat pad PFP /body weight % PFP, leptin, glucose, lipid profile including (cholesterol, triglycerides, LDL-c and VLDL-c), liver enzymes including (AST, ALT and ALP), while these treatments induced significant increase in feed intake, HDL-c and antioxidant enzymes including (GSH-GPx, SOD and CAT). The medium fat diet MFD alone or MFD containing the tested seeds and their oils improved the nutritional and biochemical parameters in non-alcoholic fatty liver disease, especially the group fed on MFD containing the combination of flaxseeds and sesame seeds which provided the diet with 10% oils, followed by the group fed on MFD containing 10% combination of these oils. The medium fat diet MFD which contain the combination of flaxseeds and sesame seeds, or their oils improved the health status of rats suffering from non-alcoholic fatty liver disease

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Effect of medium -fat diets containing flaxseed, sesame seeds and their oils on non-alcoholic fatty liver disease in rats.

Aziz

Khalil²,

Nageb³

et al. 2020

المجلة المصریة للدراسات المتخصصة

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show abstract

“…Also, feeding with sesame diet (10% w/w) reduced the level of blood glucose, cholesterol, TG, LDL, and increased HDL in alloxan-diabetic rats (Akanya et al, 2015).…”

Section: In Vivo Studiesmentioning

confidence: 91%

“…Oral treatment with sesame oil (0.5 g/kg) and sesame butter (1.25 g/kg) for 6 weeks decreased the level of glucose and elevated the level of HD against diabetic induced by STZ in rat (Haidari et al, 2016). Also, feeding with sesame diet (10% w/w) reduced the level of blood glucose, cholesterol, TG, LDL, and increased HDL in alloxan‐diabetic rats (Akanya et al, 2015).…”

Section: Atherosclerosismentioning

confidence: 99%

Effects of sesame (Sesamum indicum L.) and bioactive compounds (sesamin and sesamolin) on inflammation and atherosclerosis: A review

Hadipour,

Emami,

Tayarani‐Najaran

et al. 2023

Food Science & Nutrition

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Inflammation, oxidative stress, obesity, infection, hyperlipidemia, hypertension, and diabetes are the main causes of atherosclerosis, which in the long term lead to hardening of the arteries. In the current study, we reviewed recent findings of the mechanism of sesame and its active compounds of sesamin and sesamolin regulates on atherosclerosis. Sesame can decrease the lipid peroxidation and affect the enzymes, which control the balance of oxidative status in the body. Besides modulating the inflammatory cytokines, sesame regulates the main mediators of the signaling pathways in the process of inflammation, such as prostaglandin E2 (PGE2), nuclear factor kappa light‐chain enhancer of activated B cells (NF‐kB) and peroxisome proliferator‐activated receptor gamma (PPAR‐γ). Sesame decreases the growth of different pathogens. It fights against obesity and helps to reduce weight, body mass index (BMI), waist circumference, and lipid count of serum and liver. In addition to lowering fasting blood sugar (FBS), it decreases the hemoglobin A1c (HbA1c) and glucose levels and improves insulin function. With high content of linoleic acid, α‐linolenic acid, and total polyunsaturated fatty acid (PUFA), sesame efficiently controls the blood plasma lipids and changes the lipid profile. In the case of hypertension, it maintains the health of endothelium through multiple mechanisms and conserves the response of the arteries to vasodilation. PUFA in sesame suppresses blood clotting and fibrinogen activity. All the mentioned properties combat atherosclerosis and hardening of blood vessels, which are detailed in the present review for sesame.

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“…The liver glycogen level was significantly decreased in diabetic rats closer to normal revealing its potential effect to control hyperglycemia (Bhuvaneswari and Krishnakumari, 2012). Alloxan-induced diabetic rats provided with 10% and 20% seeds either raw or roasted as supplemented diet had significantly (p<0.05) lower levels of blood glucose, lipids and some serum enzymes (Akanya et al, 2015). Takeuchi et al (2001) found that hot-water extract from defatted sesame seed and its methanolic fraction had a reductive effect on the plasma glucose concentration of KK-Ay mice, and this effect is suggested to have been caused by the delayed glucose absorption.…”

Section: Sesamum Indicummentioning

confidence: 99%

Traditional medicinal plants used for the treatment of diabetes in the Sudan: A review

Yagi¹,

Yagi²

2018

Afr. J. Pharm. Pharmacol.

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Effect of Sesamum indicum (Linn) Seeds Supplemented Diets on Blood Glucose, Lipid Profiles and Serum Levels of Enzymes in Alloxan Induced Diabetic Rats

Cited by 5 publications

References 12 publications

Effect of medium -fat diets containing flaxseed, sesame seeds and their oils on non-alcoholic fatty liver disease in rats.

Effect of medium -fat diets containing flaxseed, sesame seeds and their oils on non-alcoholic fatty liver disease in rats.

Effects of sesame (Sesamum indicum L.) and bioactive compounds (sesamin and sesamolin) on inflammation and atherosclerosis: A review

Traditional medicinal plants used for the treatment of diabetes in the Sudan: A review

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