2005
DOI: 10.1590/s0100-879x2005000500007
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Effect of sexual steroids on the calcium content of aortic atherosclerotic plaque of oophorectomized rabbits

Abstract: We determined the effect of conjugated equine estrogen plus medroxyprogesterone acetate on calcium content of aortic atherosclerotic lesions in oophorectomized adult New Zealand rabbits submitted to a cholesterol rich diet. Five groups of 10 animals each were studied: G1 = control, G2 = cholesterol diet only, G3 = diet plus conjugated equine estrogen (0.625 mg/day); G4 and G5 = diet, conjugated equine estrogen (0.625 mg/day) plus medroxyprogesterone acetate (5 and 10 mg/day, respectively). Mean weight varied f… Show more

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Cited by 3 publications
(1 citation statement)
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“…In view of the controversy between hormonal replacement in postmenopausal women and decreased cardiovascular morbidity and mortality, and the effects of estrogens associated with progesterones, or progesterone alone, we developed a protocol to evaluate the repercussions of hormone therapy with progesterone in oophorectomized rabbits submitted to the atherogenic diet, on the development of atherosclerotic lesions induced in animals. [1][2][3][4][5][6] The present study aims to report the effects of the addition of medroxyprogesterone acetate to the hypercholesterolemic diet, at doses of 5 and 10mg/day, given to oophorectomized New Zealand rabbits, regarding: serum cholesterol and triglycerides levels; analysis of atherosclerotic lesions of the aorta; analysis of atherosclerotic lesions in coronary arteries.…”
Section: Introductionmentioning
confidence: 99%
“…In view of the controversy between hormonal replacement in postmenopausal women and decreased cardiovascular morbidity and mortality, and the effects of estrogens associated with progesterones, or progesterone alone, we developed a protocol to evaluate the repercussions of hormone therapy with progesterone in oophorectomized rabbits submitted to the atherogenic diet, on the development of atherosclerotic lesions induced in animals. [1][2][3][4][5][6] The present study aims to report the effects of the addition of medroxyprogesterone acetate to the hypercholesterolemic diet, at doses of 5 and 10mg/day, given to oophorectomized New Zealand rabbits, regarding: serum cholesterol and triglycerides levels; analysis of atherosclerotic lesions of the aorta; analysis of atherosclerotic lesions in coronary arteries.…”
Section: Introductionmentioning
confidence: 99%