Effect of Shen-yuan on haemodynamic and anti-inflammatory factors in a porcine model of acute myocardial infarction

Abstract

We previously found that Shen-yuan exerted cardioprotective activities in rodent and porcine myocardial infarction (MI) models because of its antioxidative and anti-apoptotic properties. This study aimed to investigate whether the cardioprotective effects from Shen-yuan are due to regulation of haemodynamics and inflammation in a porcine model of acute MI. Myocardial infarction was induced by left anterior descending coronary artery ligation. Low, moderate, and high doses of Shen-yuan treatment were started 1 week before MI and continued for 2 weeks after MI. Whole blood viscosity at 15 s 21 and platelet aggregation rate were significantly increased in the MI group, but were markedly attenuated by high doses of Shen-yuan. A moderate dose of Shen-yuan also restored decreased values of the peak rise of left ventricular pressure and left ventricular mean pressure after MI. Expression of the T regulatory cell marker forkhead box P3 (Foxp3) + at 14 days post-MI was lower than that in the sham-operated group. Foxp3 was significantly up-regulated in the infarcted and non-infarcted zones of the left ventricle in the Shen-yuan treatment groups. Plasma interleukin-10 and transforming growth factor-b levels were elevated by Shen-yuan treatment in a dose-dependent manner. Shen-yuan elicits cardiovascular protection by its haemodynamic stabilization and anti-inflammatory effects after onset of MI in a porcine model.