Effect of shenyan xiaobai granule on nephrin and podocin of adriamycin-induced renal injury: A randomised controlled trial

Cao, Shangmei; Huang, Wenjing; Yu, Zhuo; Yang, Xuyan; Liu, Na; Ma, Tianjiang; Tang, Shuifu; Wang, Lifan

doi:10.1016/j.jep.2019.112104

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Real-time polymerase chain reaction analysis was performed as described previously. [16] Oligonucleotide PCR primers for rat genes were as Table 1.…”

Section: Quantitative Real-time Pcrmentioning

confidence: 99%

“…For observation, DAB was used for coloration, as described previously. [16] Pathological section observation The kidneys were observed under a light microscope as described previously. [16] Western blot…”

Section: Immunohistochemistry and Pathological Section Observationmentioning

confidence: 99%

“…[16] Pathological section observation The kidneys were observed under a light microscope as described previously. [16] Western blot…”

Section: Immunohistochemistry and Pathological Section Observationmentioning

confidence: 99%

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Effect of Reynoutria Japonic and Resveratrol on Sirt1/SOD/MDA of Adriamycin-Induced Renal Injury: A Randomised Trial

Cao

liu

Sun

et al. 2021

Preprint

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Background: Mechanisms of drug-induced kidney injury include mitochondrial dysfunction and oxidative stress. Resveratrol is a natural activator of sirt1 that is related to oxidative stress.Objectives: To explore the mechanism of treating drug-induced kidney injury with Reynoutria japonica and its extract (Resveratrol).Methods: Fifty adult male SD rats were randomly divided into five groups: blank group, model group, Reynoutria japonica group, resveratrol group and Benazepril group. Except the blank group, each group used a one-time tail vein injection of 7.5mg/kg adriamycin to make the rat model of drug-induced renal injury. After three days, the proteinuria test strip showed green, which was positive for proteinuria. Each group was given the corresponding drug. ACR was measured on the seventh day every week. All rats were anaesthetized death on the fourth weekend to obtain blood and kidneys. Results: At the fourth week, the MDA levels of blank group and Reynoutria japonica group were significantly lower than those of benazepril hydrochloride group (P<0.05), and the MDA levels of resveratrol group and model group were significantly higher than those of benazepril hydrochloride group (P<0.05).The Sirt1 mRNA levels of the blank group and the Reynoutria japonica group were significantly higher than those in the benazepril hydrochloride group (P<0.05), and the Sirt1 mRNA levels of resveratrol group and model group were significantly lower than those of the benazepril hydrochloride group (P<0.05). The comparison results between groups of the Sirt1 protein expression were the same as those of the Sirt1 mRNA expression (P<0.05).Conclusions: The therapeutic effect of the Reynoutria japonica group was better than that of the Benazepril group and resveratrol group.

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“…Real-time polymerase chain reaction analysis was performed as described previously. [16] Oligonucleotide PCR primers for rat genes were as Table 1.…”

Section: Quantitative Real-time Pcrmentioning

confidence: 99%

Section: Immunohistochemistry and Pathological Section Observationmentioning

confidence: 99%

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Effect of Reynoutria Japonic and Resveratrol on Sirt1/SOD/MDA of Adriamycin-Induced Renal Injury: A Randomised Trial

Cao

liu

Sun

et al. 2021

Preprint

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Ping weisan alleviates chronic colitis in mice by regulating intestinal microbiota composition

Zhang

Cao

Shen

et al. 2020

Journal of Ethnopharmacology

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Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C/EBPβ

Chen,

Liu,

et al. 2024

Journal of Ethnopharmacology

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Effect of shenyan xiaobai granule on nephrin and podocin of adriamycin-induced renal injury: A randomised controlled trial

Cited by 4 publications

References 14 publications

Effect of Reynoutria Japonic and Resveratrol on Sirt1/SOD/MDA of Adriamycin-Induced Renal Injury: A Randomised Trial

Effect of Reynoutria Japonic and Resveratrol on Sirt1/SOD/MDA of Adriamycin-Induced Renal Injury: A Randomised Trial

Ping weisan alleviates chronic colitis in mice by regulating intestinal microbiota composition

Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C/EBPβ

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