Effect of Shikonin on Cardiac Wound Healing in Mice

Abstract

Shikonin has been shown to have properties of improving open wound healing, but it is not known whether shikonin is effective in promoting cardiac repair after myocardial infarction (MI). We hypothesize that shikonin can improve wound healing in infarcted hearts. We created MI models by ligating the coronary artery in mice. We treated the infarcted mice with 5 mg/kg of shikonin a day through oral gavage, or the same volume of distilled water was given to the control group. After seven days of treatment, we documented the heart weight and body weight, and the hearts were photographed and the infarct size was measured. The ratio of heart weight to body weight was calculated.We found that the infarct area in treated mice was significantly smaller than in the control group. While there was no significant difference in body weight between the two groups, but the ratio of heart weight to body weight in the treated group was much smaller than in the control group. In conclusion, shikonin was effective in helping wound healing in the heart after MI. Future studies will be directed to further study how shikonin functions at the cellular level and whether it improves cardiac function.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

Influencia de los parámetros operacionales de carbonización hidrotermal asistida por microondas en la obtención de productos de valor energético: una revisión

“…Sin embargo, el rendimiento del hidrochar disminuyó con el aumento de la temperatura y el tiempo, se obtiene un rendimiento de hidrocarburos del 80 % a 180 °C en contraste con un rendimiento del 41 % a 260 °C. Lo cual posiblemente fue causado por la mayor descomposición primaria de las estructuras de biomasa o descomposición secundaria del residuo sólido [34].…”