Effect of Shitei-To, a traditional Chinese medicine formulation, on pentylenetetrazol-induced kindling in mice

Minami, E.; Shibata, Hiroki; Nomoto, Masahiro; Fukuda, Takeo

doi:10.1016/s0944-7113(00)80024-0

Cited by 12 publications

(4 citation statements)

References 11 publications

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“…It is noted for its actions to safely relieve nausea from many causes including morning sickness, labyrinthis, and motion sickness [33]. It helps improve digestion [34], lower cholesterol [35], and prevent seizures [36]. It also prevents cancer [37], the formation of blood clots which may cause heart attacks or strokes [38][39], protects the liver from chemical injury [40][41] and alleviates pain from arthritis [42][43].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antimicrobial Evaluation of Lozenges Containing Extract of Garlic and Ginger

Esimone¹,

Okoye²,

Odimegwu³

et al. 2011

Int J Health Res

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and full-text of published articles. The journal is devoted to the promotion of health sciences and related disciplines (including medicine, pharmacy, nursing, biotechnology, cell and molecular biology, and related engineering fields). It seeks particularly (but not exclusively) to encourage multidisciplinary research and collaboration among scientists, the industry and the healthcare professionals. It will also provide an international forum for the communication and evaluation of data, methods and findings in health sciences and related disciplines. The journal welcomes original research papers, reviews and case reports on current topics of special interest and relevance. All manuscripts will be subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication) will be published without delay. The maximum length of manuscripts should normally be 10,000 words (20 single-spaced typewritten pages) for review, 6,000 words for research articles, 3,000 for technical notes, case reports, commentaries and short communications.

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Section: Introductionmentioning

confidence: 99%

In Vitro Antimicrobial Evaluation of Lozenges Containing Extract of Garlic and Ginger

Esimone¹,

Okoye²,

Odimegwu³

et al. 2011

Int J Health Res

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“…Repeated dosing of Shitei-To at 3 g/kg protected against the development of chemically induced seizures and convulsions. 147,148 However, the specific contribution of clove extract cannot be determined.…”

Section: A Effect Of Clove Extractsmentioning

confidence: 99%

Clove

2023

Nutr Today

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“…The traditional Chinese medicine Shitei-To, which is a mixture of extracts from three medicinal herbs, Shitei ( D. kaki calyx), Shokyo ( Zingiberis rhizoma ), and Choji ( Caryophylli flos ), has long been used for the treatment of hiccups in Japan and China (Minami et al. 2000 ). D. kaki calyx contains various biological compounds, including gallic acid, β-sitosterol, trifolin, kaempferol, quercetin, and tannins (Sunity and Himanshu 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Diospyros kaki calyx inhibits immediate-type hypersensitivity via the reduction of mast cell activation

Kim

Park

Shin

et al. 2017

Pharmaceutical Biology

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Context:Diospyros kaki L. (Ebenaceae) fruit is widely distributed in Asia and is known to exert anti-inflammatory and antithrombotic effects.Objective: We evaluated the inhibitory effect of aqueous extract of D. kaki calyx (AEDKC) on mast cell-mediated immediate-type hypersensitivity and underlying mechanism of action.Materials and methods: For in vivo, ovalbumin (OVA)-induced active systemic anaphylaxis (ASA) and immunoglobulin (Ig) E-mediated passive cutaneous anaphylaxis (PCA) models were used. In the ASA, AEDKC (1–100 mg/kg) was orally administered 3 times during 14 days. In the PCA, AEDKC was orally treated 1 h before the antigen challenge. The control drug dexamethasone was used to compare the effectiveness of AEDKC. For in vitro, IgE-stimulated RBL-2H3 cells and primary cultured peritoneal mast cells were used to determine the role of AEDKC (0.01–1 mg/mL).Results: Oral administration of AEDKC dose dependently suppressed rectal temperature decrease and increases in serum histamine, total IgE, OVA-specific IgE, and interleukin (IL)-4 in the ASA. In the PCA, AEDKC reduced Evans blue pigmentation. Compared to dexamethasone (10 mg/kg), AEDKC (100 mg/kg) showed similar inhibitory effects in vivo. AEDKC concentration dependently suppressed the release of histamine and β-hexosaminidase through the reduction of intracellular calcium in mast cells. In addition, AEDKC decreased the expression and secretion of tumour necrosis factor-α and IL-4 by the reduction of nuclear factor-κB. The inhibitory potential of AEDKC (1 mg/mL) was similar with dexamethasone (10 μM) in vitro.Conclusions: We suggest that AEDKC may be a potential candidate for the treatment of mast cell-mediated allergic diseases.

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Effect of Shitei-To, a traditional Chinese medicine formulation, on pentylenetetrazol-induced kindling in mice

Cited by 12 publications

References 11 publications

In Vitro Antimicrobial Evaluation of Lozenges Containing Extract of Garlic and Ginger

In Vitro Antimicrobial Evaluation of Lozenges Containing Extract of Garlic and Ginger

Clove

Diospyros kaki calyx inhibits immediate-type hypersensitivity via the reduction of mast cell activation

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