Effect of short and long-term treatments by a low level of dietary L-carnitine on parameters related to fatty acid oxidation in Wistar rat

Interaction between Altered Insulin and Lipid Metabolism in CEACAM1-inactive Transgenic Mice

“…Although further examination of metabolic fluxes are needed to confirm our observation, the current data suggest that, similar to its effect on obese Zucker (40) and Wistar rats (41), carnitine normalized plasma FFA levels in L-SACC1 mice mainly by reducing its supply. That carnitine may have increased oxidation of FFAs in several sites, including muscle, is possible.…”

Effect of <i>L</i>-Carnitine on Weight Loss and Body Composition of Rats Fed a Hypocaloric Diet

“…If the activity of this enzyme is reduced or the carnitine concentration is very low, the rate of ß-oxidation and the formation of ketone bodies are diminished [25]. In the study by Martin-Privat [22], the concentration of ketone bodies in the blood of Wistar rats was increased by carnitine supplementation, unlike our findings. In neonates, too, carnitine supplementation of a diet containing medium-chain fatty acids raised concentrations of ketone bodies in the blood [26].…”

“…L-Carnitine supplementation did not lower the proportion of fat in the carcass nor did it reduce the size of the fat pads. The hypothesis of Martin-Privat [22] that carnitine supplementation encourages a preferential energetic utilisation of triglycerides due to increased mitochondrial ß-oxidation of fatty acids, was thus not proved in rats. Nor was there any evidence of changes in body composition in the form of a higher protein content and reduced fat content as observed in several species during the growth phase due to L-carnitine supplementation [7][8][9][10].…”

“…The hypothesis of Martin-Privat [22] that carnitine supplementation encourages a preferential energetic utilisation of triglycerides due to increased mitochondrial ß-oxidation of fatty acids, was thus not proved in rats. Nor was there any evidence of changes in body composition in the form of a higher protein content and reduced fat content as observed in several species during the growth phase due to L-carnitine supplementation [7][8][9][10]. This suggests that the capacity for ß-oxidation, especially the transport of activated fatty acids into the mitochondrium, is sufficient with endogenously synthesised carnitine, even if lipolysis is extensive.…”

“…According to some studies exogenous carnitine supplementation reduces plasma lipids in hyperlipidaemic rat and rabbits [3][4][5][6]. In a recent study carnitine supplementation resulted in a reduction of the peri-epididymal adipose tissue of rats under a controlled feeding regime [7]. The combine administration of carnitine with caffeine and choline to rats reduced body fat levels and concentrations of leptin in the blood.…”