Peritoneal macrophages function modulation by L-carnitine in aging rats

İzgüt‐Uysal, V. Nimet; Ağaç, Arzu; Karadoğan, İhsan; Derın, Narin

doi:10.1007/bf03324561

Cited by 20 publications

(10 citation statements)

References 28 publications

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“…Interestingly, reduced expression of FcγRIII (CD16) and phagocytosis have been observed in neutrophils from aged humans (46). Similar studies in macrophage populations suggest a reduced phagocytic potential with advanced age (48–50). Thus, we sought to determine if differences in phagocytosis and FcγRIII expression may contribute to delayed resolution of bacterial clearance in our model.…”

Section: Resultssupporting

confidence: 56%

Reduced Neutrophil Chemotaxis and Infiltration Contributes to Delayed Resolution of Cutaneous Wound Infection with Advanced Age

Brubaker

Rendón

Ramírez

et al. 2013

The Journal of Immunology

144

108

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Advanced age is associated with alterations in innate and adaptive immune responses, which contribute to an increased risk of infection in elderly patients. Coupled with this immune dysfunction, elderly patients demonstrate impaired wound healing with elevated rates of wound dehiscence and chronic wounds. To evaluate how advanced age alters the host immune response to cutaneous wound infection, we developed a murine model of cutaneous Staphylococcus aureus wound infection in young (3–4 month) and aged (18–20 month) BALB/c mice. Aged mice exhibit increased bacterial colonization and delayed wound closure over time compared to young mice. These differences were not attributed to alterations in wound neutrophil or macrophage TLR2 or FcγRIII expression, or age-related changes in phagocytic potential and bactericidal activity. To evaluate the role of chemotaxis in our model, we first examined in vivo chemotaxis in the absence of wound injury to KC, a neutrophil chemokine. In response to a subcutaneous injection of KC, aged mice recruited fewer neutrophils at increasing doses of KC compared to young mice. This paralleled our model of wound infection, where diminished neutrophil and macrophage recruitment was observed in aged mice relative to young mice despite equivalent levels of KC, MIP-2 and MCP-1 chemokine levels at the wound site. This reduced leukocyte accumulation was also associated with lower levels of ICAM-1 in wounds from aged mice at early time points. These age-mediated defects in early neutrophil recruitment may alter the dynamics of the inflammatory phase of wound healing, impacting macrophage recruitment, bacterial clearance and wound closure.

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Section: Resultssupporting

confidence: 56%

Reduced Neutrophil Chemotaxis and Infiltration Contributes to Delayed Resolution of Cutaneous Wound Infection with Advanced Age

Brubaker

Rendón

Ramírez

et al. 2013

The Journal of Immunology

144

108

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“…Recently, Lcarnitine has been proposed as a potential adjuvant treatment to improve anaemia, thrombocytopenia, leukopenia and immunological function. [68][69][70][71][72][73] In a recent study, L-carnitine added to Peg-IFN-α plus ribavirin led to less decrease of platelet count during antiviral therapy. 74 Some studies indicate that L-carnitine modulates platelet functions and production through antioxidant mechanisms and the inhibition of the arachidonic acid cascade.…”

Section: L-carnitinementioning

confidence: 98%

Chronic hepatitis C-associated thrombocytopenia: aetiology and management

Fouad

2013

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Thrombocytopenia is perhaps the most common haematological abnormality in patients with chronic hepatitis C virus (HCV) infection. In these patients, the presence of thrombocytopenia may be a limiting factor when considering antiviral therapy and may be associated with decreased sustained virological response rates. Thrombocytopenia may interfere with diagnostic procedures such as liver biopsy, because of risk of bleeding.Pathogenetic mechanisms include hypersplenism secondary to portal hypertension, bone marrow suppression resulting from either HCV itself or interferon treatment, and aberrations of the immune system resulting in the formation of anti-platelet antibodies and/or immunecomplexes that bind to platelets and facilitate their premature clearance. The ability to increase platelet levels could significantly reduce the need for platelet transfusions and facilitate the use of interferon-based antiviral therapy and other medically indicated treatments in patients with liver disease. Therapeutic options include pharmacological and non-pharmacological therapies. This review summarizes the available data on these therapeutic options. KEYWORDS: thrombocytopenia, hepatitis C virus (HCV), cytokines Definition and prevalenceThrombocytopenia has been defined as a platelet count <150,000 cells/µL. In a recent systematic review, the definitions of thrombocytopenia varied between studies and were based either on platelet counts, with threshold levels ranging between <100,000 cells/µL and <180,000 cells/µL or on criteria set in haematological guidelines. The prevalence of thrombocytopenia related to chronic liver disease has been reported as 15% to 70% in patients with advanced fibrosis and portal hypertension, depending on the stage of the disease and the platelet level used to define thrombocytopenia. In patients with chronic HCV infection, the prevalence of thrombocytopenia ranged from 0.16% to 45.4% and more than half of the studies reported a prevalence of 24% or more. 1 Aetiology of thrombocytopenia in patients with chronic HCVThe pathophysiology of thrombocytopenia in patients with HCV-related chronic liver disease is complex and involves the interaction of multiple factors. In general, these factors may be

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“…The effects of L-carnitine on lymphocyte and neutrophil counts are compatible with the findings of previously published studies. 12 Whenever prominent neutrophilia develops or cellular immunity is suppressed, NLR increases. So a smaller activation of inflammatory response evaluated by neutrophil count and a lesser deterioration of cellular immunity measured by lymphocytic count can be defined as a favorable pattern of systemic leukocytic alteration.…”

Section: Discussionmentioning

confidence: 99%

“…L-carnitine is also known to enhance neutrophil and macrophage functions in rats at lower concentrations. 12 However, the effect of L-carnitine on NLR still needs to be clarified. Hence, in this doubleblinded, randomized, and placebo-controlled study, we aimed to evaluate whether preoperative intravenous (IV) L-carnitine supplementation has effects on WBCs, total leukocytes, neutrophils, lymphocytes, and especially NLR in patients undergoing CABG.…”

mentioning

confidence: 99%

L-Carnitine Supplementation Reduces Short-Term Neutrophil-Lymphocyte Ratio in Patients Undergoing Coronary Artery Bypass Grafting

Aldemir

Pektaş

Parlar³

et al. 2015

International Surgery

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This study aims to investigate whether preoperative L-carnitine supplementation affects the neutrophil-to-lymphocyte ratio (NLR) in patients undergoing coronary artery bypass grafting surgery. The neutrophil-to-lymphocyte ratio is an inflammatory marker that has proven usefulness for predicting postoperative complications in coronary artery bypass surgery. A lot of studies concerning the role of L-carnitine in the immune system have been performed, contradictory results have been reported on its effects on absolute numbers of WBC subtypes. This randomized, double-blinded, placebo-controlled study was conducted among patients scheduled for coronary artery bypass grafting surgery between June 2012 and December 2013 in our cardiovascular surgery clinic. A total of 60 consecutive patients were randomized and divided into 2 groups. The first group received 2 g of L-carnitine in 1000 mL of 0.9% saline solution infused over 24 hours for each of the 3 preoperative days (L-carnitine group, n ¼ 30), or only 1000 mL of 0.9% saline solution for the same time period (placebo group, n ¼ 30). The basal values of leukocyte,

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Peritoneal macrophages function modulation by L-carnitine in aging rats

Abstract: The findings suggest that L-carnitine administration may be useful in reversing some age-related changes.

Cited by 20 publications

References 28 publications

Reduced Neutrophil Chemotaxis and Infiltration Contributes to Delayed Resolution of Cutaneous Wound Infection with Advanced Age

Reduced Neutrophil Chemotaxis and Infiltration Contributes to Delayed Resolution of Cutaneous Wound Infection with Advanced Age

Chronic hepatitis C-associated thrombocytopenia: aetiology and management

L-Carnitine Supplementation Reduces Short-Term Neutrophil-Lymphocyte Ratio in Patients Undergoing Coronary Artery Bypass Grafting

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