L-Carnitine Supplementation Reduces Short-Term Neutrophil-Lymphocyte Ratio in Patients Undergoing Coronary Artery Bypass Grafting

Aldemir, Mustafa; Pektaş, Mehmet Bilgehan; Parlar, Ali İhsan; Akçi, Önder; Emren, Sadık Volkan; Tecer, Evren; Adalı, Fahri; Yüksel, Şeref; Darçin, Osman Tansel

doi:10.9738/intsurg-d-15-00071.1

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…demonstrated that L-CN supplementation reduced serum CRP (a marker of systemic inflammation) and plasma fibrinogen (an inflammation-associated coagulation factor) in patients who underwent hemodialysis [34] and increased the total antioxidant capacity and decreased IL-6 and TNF-α, which were effective in decreasing inflammatory status [35]. However, L-CN reduces the accumulation of neutrophil protein kinase C receptor due to its inhibition [36], and supplementation with L-CN reduces the postoperative neutrophil-lymphocyte ratio in the short term [37]. In this study, L-CN was closely related to GBB in DVT, and L-CN was more correlated with leukocytes (neutrophils, lymphocytes, monocytes), and for the first time, we also found a positive correlation between GBB and APTT and TT.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of deep vein thrombosis by γ-butylbetaine and L-carnitin in plasma and urine revealed based on untargeted and targeted metabolomics

Zeng,

Wang,

Chi

et al. 2024

Preprint

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Deep vein thrombosis (DVT) has become an important factor in the global disease burden. In this study, the differential metabolites in urine were screened by untargeted metabolomics to find metabolic markers to compensate for the poor specificity and single defect of D-dimer, γ-butyl betaine (GBB), and L-carnitine (L-CN). Ultra-high performance liquid chromatography-mass spectrometry ( UPLC-MS / MS ) was used to verify the levels of GBB and L-CN in clinical and rat blood and urine at different stages of DVT, and the diagnostic titer and correlation analysis of GBB and L-CN with DVT were analyzed in an all-round manner. The levels of GBB and L-CN in plasma and urine were lower in patients with DVT and in Sprague-Dawley rats than in the control group (P < 0.05), and the trends of GBB and L-CN were similar in plasma and urine of humans and rats with DVT. In human plasma, the area under the curve (AUC) of GBB combined with D-dimer was 0.914 (P < 0.001) in the acute group and 0.895 (P < 0.001) for L-CN combined with D-dimer in the subacute group. In human urine, the AUC of L-CN combined with GBB in the subacute group was 0.855 (P < 0.001). Therefore, GBB and L-CN are closely related to the development and progression of DVT and can be used to screen and diagnose DVT at different phases. Moreover, GBB and L-CN expression levels are similar in humans and rats, providing precise indicators and animal models for the in-depth study of the DVT formation mechanism.

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Section: Discussionmentioning

confidence: 99%

Diagnosis of deep vein thrombosis by γ-butylbetaine and L-carnitin in plasma and urine revealed based on untargeted and targeted metabolomics

Zeng,

Wang,

Chi

et al. 2024

Preprint

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L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management

Sahebnasagh

Avan

Monajati

et al. 2022

CMC

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: In this review, we discussed the biological targets of carnitine, its effects on immune function, and how L-carnitine supplementation may help critically ill patients. L-carnitine is a potent antioxidant. L-carnitine depletion has been observed in prolonged intensive care unit (ICU) stays, while L-carnitine supplementation has beneficial effects in health promotion and regulation of immunity. It is essential for the uptake of fatty acids into mitochondria. By inhibiting the ubiquitin-proteasome system, down-regulation of apelin receptor in cardiac tissue, and reducing β-oxidation of fatty acid, carnitine may decrease vasopressor requirement in septic shock and improve clinical outcomes of this group of patients. We also have an overview of animal and clinical studies that have been recruited for evaluating the beneficial effects of L-carnitine in the management of sepsis/ septic shock. Additional clinical data are required to evaluate the optimal daily dose and duration of L-carnitine supplementation.

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Evaluation of platelet indices in acute, subacute and, chronic phases of deep venous thrombosis

Ada

Polat

2019

Cumhuriyet Medical Journal

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The etiology of deep vein thrombosis disease is multifactorial, and currently, it is seen as a public health problem. Simple, cheap and useful tests that can be used for diagnosis, treatment, and follow-up is increasingly needed day by day because of the increasing number of patients. For this purpose, the changes of platelet indices in routine hemogram tests during DVT follow-up were examined retrospectively. Method: This study is a retrospective analysis of patients who diagnosed with deep venous thrombosis in Sivas Cumhuriyet University School of Medicine between 01.01.2017-31.12.2018 years. The investigation started after the decision of Sivas Cumhuriyet University Local Ethics Committee No. 2019-02/67. The acute, subacute, and chronic phase parameters of patients with deep venous thrombosis were evaluated. The study included 72 patients who developed DVT. Platelet indexes and other hemogram parameters were analyzed statistically according to the phases of deep vein thrombosis. Results: 55.6% of the patients were female, and 44.4% were male. DVT was found most commonly in the left femoral region (48.6%). PDW and MPV tended to increase rapidly in the acute phase of deep vein thrombosis and managed to fall in the subacute and chronic phases. However, there was no statistically significant change in platelet count and platelet crit. Conclusions: PDW and MPV appear to be useful markers in the follow-up of all stages of deep vein thrombosis. It is evident that with the developing technology, more sensitive and specific parameters of platelet indices will be obtained.

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L-Carnitine Supplementation Reduces Short-Term Neutrophil-Lymphocyte Ratio in Patients Undergoing Coronary Artery Bypass Grafting

Cited by 3 publications

References 34 publications

Diagnosis of deep vein thrombosis by γ-butylbetaine and L-carnitin in plasma and urine revealed based on untargeted and targeted metabolomics

Diagnosis of deep vein thrombosis by γ-butylbetaine and L-carnitin in plasma and urine revealed based on untargeted and targeted metabolomics

L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management

Evaluation of platelet indices in acute, subacute and, chronic phases of deep venous thrombosis

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