Effect of short-term high-protein compared with normal-protein diets on renal hemodynamics and associated variables in healthy young men

Frank, Helga; Graf, Juliane; Amann-Gassner, Ulrike; Bratke, Renate; Daniel, Hannelore; Heemann, Uwe; Hauner, Hans

doi:10.3945/ajcn.2009.27601

Cited by 56 publications

(61 citation statements)

References 38 publications

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“…Also, our data reveal a J-shaped relationship between UA and the intake of all dietary components except fiber. Previous investigations regarding the association between dietary intake and UA showed increased serum UA levels with higher intake of sugar-sweetened beverages (24), calories (25), and protein (25,26), and lower intake of vitamin C (27). A study using NHANES data in adults revealed that a higher intake of fiber correlated with lower serum UA levels (28), which is consistent with our findings.…”

Section: Discussionmentioning

confidence: 95%

Serum uric acid in US adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors

et al. 2012

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Section: Discussionmentioning

confidence: 95%

Serum uric acid in US adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors

et al. 2012

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“…Indeed, as shown previously, HP diets cause elevation of glomerular filtration rate and hyperfiltration (Kim and Linkswiler, 1979;Schuette et al, 1980;Zemel et al, 1981;Brenner et al, 1982;Bilo et al, 1989;Metges and Barth, 2000;Tuttle et al, 2002;Frank et al, 2009;Burodom, 2010). In animal models, HP diets induce a renal hypertrophy (Addis, 1926;Wilson, 1933;Hammond and Janes, 1998) but not systematically (Robertson et al, 1986;Collins et al, 1990;Lacroix et al, 2004), and to our knowledge, the link between protein-induced renal hypertrophy or hyperfiltration and the initiation of renal disease in healthy individuals has not been clearly shown.…”

Section: Protein Intake Kidney Function and Kidney Stone Formationmentioning

confidence: 87%

Protein intake, calcium balance and health consequences

et al. 2011

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High-protein (HP) diets exert a hypercalciuric effect at constant levels of calcium intake, even though the effect may depend on the nature of the dietary protein. Lower urinary pH is also consistently observed for subjects consuming HP diets. The combination of these two effects was suspected to be associated with a dietary environment favorable for demineralization of the skeleton. However, increased calcium excretion due to HP diet does not seem to be linked to impaired calcium balance. In contrast, some data indicate that HP intakes induce an increase of intestinal calcium absorption. Moreover, no clinical data support the hypothesis of a detrimental effect of HP diet on bone health, except in a context of inadequate calcium supply. In addition, HP intake promotes bone growth and retards bone loss and low-protein diet is associated with higher risk of hip fractures. The increase of acid and calcium excretion due to HP diet is also accused of constituting a favorable environment for kidney stones and renal diseases. However, in healthy subjects, no damaging effect of HP diets on kidney has been found in either observational or interventional studies and it seems that HP diets might be deleterious only in patients with preexisting metabolic renal dysfunction. Thus, HP diet does not seem to lead to calcium bone loss, and the role of protein seems to be complex and probably dependent on other dietary factors and the presence of other nutrients in the diet.

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“…In addition, accurate timing ensured a complete 24-hour urine collection, which took place during the 24-hour ambulatory monitoring under the supervision of healthcare personnel as reported previously (29). Another possible limitation is that we did not control for protein intake that is known to affect GFR (30). However, our data were obtained from a homogeneous cohort of people with † P=0.02 versus Hyp→Nor.…”

Section: Discussionmentioning

confidence: 99%

Relationship between GFR and Albuminuria in Stage 1 Hypertension

Palatini

Mos

Ballerini

et al. 2013

Clinical Journal of the American Society of Nephrology

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on behalf of the HARVEST Investigators Summary Background and objectives Whether glomerular hyperfiltration is implicated in the development of microalbuminuria in hypertension is not well known. This prospective study investigated the relationship between changes in GFR and microalbuminuria in hypertension.Design, setting, participants, & measurements This study assessed 534 stage 1 hypertensive participants from the Hypertension and Ambulatory Recording Venetia Study (n=386 men) without microalbuminuria at baseline, who were recruited from 1990 to 1995 and followed for a median of 8.5 years. Mean age was 33.968.6 years and mean BP was 146.6610.5/94.065.0 mmHg. Creatinine clearance and 24-hour urinary albumin were measured at study entry and end. Participants were defined as normofilterers (normo) or hyperfilterers (hyper) according to whether GFR was ,150 or $150 ml/min per 1.73 m 2 , respectively. Participants were divided into four groups based on GFR changes from baseline to follow-up end: normo→normo (n=395), normo→hyper (n=31), hyper→hyper (n=61), and hyper→normo (n=47).Results Microalbuminuria progressively increased across the four groups and was 5.3% in normo→normo, 9.7% in normo→hyper, 16.4% in hyper→hyper, and 36.2% in hyper→normo (P,0.001). This association held true in a multivariable logistic regression in which several confounders, ambulatory BP, and other risk factors were taken into account (P,0.001). In particular, hyperfilterers whose GFR decreased to normal at study end had an adjusted odds ratio of 7.8 (95% confidence interval, 3.3-18.2) for development of microalbuminuria compared with participants with normal GFR throughout the study.Conclusions These data support the hypothesis for a parabolic association between GFR and urinary albumin in the early stage of hypertension.

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Effect of short-term high-protein compared with normal-protein diets on renal hemodynamics and associated variables in healthy young men

Abstract: A short-term HP diet alters renal hemodynamics and renal excretion of uric acid, sodium, and albumin. More attention should be paid to the potential adverse renal effects of HP diets.

Cited by 56 publications

References 38 publications

Serum uric acid in US adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors

Serum uric acid in US adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors

Protein intake, calcium balance and health consequences

Relationship between GFR and Albuminuria in Stage 1 Hypertension

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