Effect of short-term weight loss on the metabolic syndrome and conduit vascular endothelial function in overweight adults

Brook, Robert D.; Bard, Robert L.; Glazewski, Lynn; Kehrer, Christine; Bodary, Peter F.; Eitzman, Daniel L; Rajagopalan, Sanjay

doi:10.1016/j.amjcard.2004.01.009

Cited by 87 publications

(54 citation statements)

References 14 publications

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“…Hem obezitenin hem de fiziksel inaktivitenin HDL düşüklüğü, trigliserid yüksekli-ği, hipertansiyon ve açlık kan şekeri yüksekliği gibi MetS bileşenleri ile benzer şekilde etkileşime sahip olduğu bilinmektedir (5,(39)(40)(41)(42)(43)(44). Yapılan çalışmalar egzersizin obezitenin ve yüksek trigliseridin kontrol altına alınması ve HDL kolesterolün yükseltil-mesine yardımcı olduğunu göstermektedir (39-43, 45, 46).…”

Section: Discussionunclassified

Frequency and affecting factors of metabolic syndrome in women older than 20 years of age

Kıtış¹,

Bilgili²,

Hisar³

et al. 2010

Anadolu Kardiyol Derg

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ÖZETOb jec ti ve: Metabolic syndrome (MetS) is a major cause of morbidity and mortality affecting increasing number of people. This was a crosssectional study aiming to identify the prevalence of MS and risk factors in women aged 20 years and older. Methods: Study's universe consisted of women aged 20 years and older living in Gölbaşı Ali Soydan Health Centre's territory. Eight hundred fifty women were accessed among them. Data were collected by a questionnaire. Measurements were done in the health centre following fasting 12 hours. One way ANOVA, correlation and logistic regression analyses were used for statistical analysis.Results: The mean age was 39.4 years, 62% have primary school education. Prevalence of MetS was found 39.1%; low high-density lipoprotein (HDL) and abdominal obesity were the most common MetS components. On the contrary, education and age had negative correlation with HDL and positive correlation with other MetS components. Age (OR=1.091; 95%CI = 1.071-1.110; p<0.0001), and education lower than middle school (literate OR=2.491; 95%CI = 1.334-2.855; p=0.007; primary school OR=1.841; 95%CI 1.281-2.855; p=0.006) were found to increase MetS risk. Conclusion: Even more than half of our study group who has urban life style has two or more MetS components. Because of older age, accelerant factor for MetS, improving of healthy lifestyle behaviors in study group with genetic and environmental risk factors should be primary goal in terms of prevention of cardiovascular diseases and diabetes. (Anadolu Kardiyol Derg 2010; 10: 111-9)

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Section: Discussionunclassified

Frequency and affecting factors of metabolic syndrome in women older than 20 years of age

Kıtış¹,

Bilgili²,

Hisar³

et al. 2010

Anadolu Kardiyol Derg

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“…[7][8][9][10] However, reductions in LDL cholesterol and fasting glucose concentrations but not weight loss per se were associated with improvements in FMD. [11][12][13] Disturbed endothelial function can also be assessed using the level of molecules secreted by the endothelium such as adhesion molecules vascular cell adhesion molecule-1 (VCAM-1), soluble intracellular adhesion molecule-1 (sI-CAM1), E-selectin, plasminogen activator inhibitor 1 (PAI-1) and tissue plasminogen activator (TPa), and there is evidence that these molecules decrease after weight loss. 14 Whether the changes seen in these molecules reflect the changes seen in endothelial nitric oxide (NO)-dependent processes such as FMD or small vessel compliance is not known.…”

Section: Introductionmentioning

confidence: 99%

Effect of weight loss on inflammatory and endothelial markers and FMD using two low-fat diets

et al. 2005

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OBJECTIVE: Cardiovascular disease is strongly associated with obesity and there is evidence that weight loss has positive effects on cardiovascular disease risk. The aims of this study were to compare meal replacements (MR) with a conventional low-fat diet as weight loss strategies and to examine the effect of weight loss on flow-mediated dilatation (FMD) and other markers of endothelial function in overweight Australians with raised triglycerides (TG) (42 mmol/l). RESEARCH METHODS: Subjects matched for age, gender, fasting plasma TG and body mass index were randomized to two low-fat high-carbohydrate weight loss strategies (both o6000 kJ), one using MR and the other a structured eating plan, control (C). Subjects followed both diets for 3 months. In total, 55 subjects completed the study. FMD, pulse wave velocity and blood pressure (BP) were measured at baseline and at 3 months, as were fasting blood samples for lipids, glucose, insulin, C reactive protein (CRP) and endothelium-derived factors. RESULTS: Mean weight loss was 6.373.7 kg (6.074.2 vs 6.6373.35 kg, MR vs C) with no difference between diet groups. TG, insulin, CRP, plasminogen activator inhibitor 1 (PAI-1) and soluble intracellular adhesion molecule-1 (sICAM1) fell after weight loss, but FMD did not change. Systolic BP fell by 8 mmHg and pulse wave velocity improved. DISCUSSION: In subjects with elevated TG, weight loss resulted in significant improvements in cardiovascular risk markers, particularly endothelium-derived factors (PAI-1 and sICAM1). However, FMD did not improve with weight loss.

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“…Orlistat, an FDA approved drug, binds intestinal fat and reduces its absorption, has been shown to reduce weight, LDL, fasting insulin and lepitin and to a lesser extent reduce the level of CRP [126]. In addition to Orilstat, Sibutramine is another drug that has been shown to cause moderate weight loss in CMS patients has also received FDA approval [127,128]. A new generation drug, Rimonabant, a selective cannabinoid receptor-1 (CB1) antagonist, has been shown to reduce weight, improve circumference, increase HDL cholesterol levels, reduce LDL cholesterol, TG and reduce insulin resistance in patients suffering from CMS [129].…”

Section: Weight Lossmentioning

confidence: 99%

Cardio Metabolic Syndrome: A Global Epidemic

Kelli¹,

Kassas²,

Lattouf

2016

J Diabetes Metab

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Cardio Metabolic Syndrome (CMS), also known as insulin resistance syndrome or metabolic syndrome X, is a combination of metabolic disorders or risk factors that essentially includes a combination of diabetes mellitus, systemic arterial hypertension, central obesity and hyper-lipidemia. Common to these diseases of metabolism is the associated development of atherosclerotic cardiovascular disease (ASCVD). Studies have shown a strong link between CMS and increased prevalence of peripheral vascular diseases, coronary artery disease and myocardial infarctions as well as cerebro-vascular arterial diseases and stroke.

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Effect of short-term weight loss on the metabolic syndrome and conduit vascular endothelial function in overweight adults

Cited by 87 publications

References 14 publications

Frequency and affecting factors of metabolic syndrome in women older than 20 years of age

Frequency and affecting factors of metabolic syndrome in women older than 20 years of age

Effect of weight loss on inflammatory and endothelial markers and FMD using two low-fat diets

Cardio Metabolic Syndrome: A Global Epidemic

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