Effect of Silica Gel on Stability and Biological Availability of Ascorbic Acid

Ritter, E. De; Magid, Louis; Osadca, M; Rubin, Saul H.

doi:10.1002/jps.2600590218

Cited by 26 publications

(5 citation statements)

References 7 publications

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“…Larger value of the energy gap implies high kinetic stability and low chemical reactivity. This is in good agreement with previous report that vitamin C is unstable in water [30]. The energy of HOMO and LUMO was calculated -7.11 and -3.11 eV for 2, -6.46 and -1.95 eV for 3, and -6.12 and -1.26 eV for 4 in the gas phase, respectively.…”

Section: The Uv-visible Spectrumsupporting

confidence: 92%

Uv-Vis, NMR and Ft-Ir Spectra of Tautomers of Vitamin C. Experimental and DFT Calculations

Dabbagh

Azami

Farrokhpour

et al. 2014

J. Chil. Chem. Soc.

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Experimental and computational analysis of spectroscopic parameters of L-ascorbic acid (vitamin C) and its tautomers was investigated by Density Functional Theory (DFT) using B3LYP method. The optimized geometries and calculated vibrational frequencies were evaluated. The latter was compare with those of experimental values. The λ max values of L-ascorbic acid were found 259 (at pH = 3) experimentally, 238 and 247 nm calculated in the gas and water phase at TD-DFT methods, respectively.

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Section: The Uv-visible Spectrumsupporting

confidence: 92%

Uv-Vis, NMR and Ft-Ir Spectra of Tautomers of Vitamin C. Experimental and DFT Calculations

Dabbagh

Azami

Farrokhpour

et al. 2014

J. Chil. Chem. Soc.

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“…As has been previously reported in studies on the relationship between water content and degradation of water-soluble [2][3][4][5] and waterinsoluble drugs, the water content of solid oral dosage forms should be low in order to stabilize the solid drug content during storage.…”

Section: Introductionmentioning

confidence: 88%

Hygroscopicity of a sugarless coating layer formed by the interaction between mannitol and poly(vinyl alcohol) (PVA)

Higuchi

Tanaka

Tamura

et al. 2014

Colloids and Surfaces B: Biointerfaces

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“…This can result in the situation where more hygroscopic excipients stabilize moisture-sensitive drugs. De Ritter et al (1970) used silica gel and Gore and Banker (1979) used colloidal silica to prevent degradation of moisture sensitive APIs. Schepky (1976) suggested including inorganic or organic salts, e.g.…”

Section: Use Of Excipients To Improve Stabilitymentioning

confidence: 99%

Excipient Selection in Oral Solid Dosage Formulations Containing Moisture Sensitive Drugs

Rajabi‐Siahboomi

Levina²,

Upadhye

et al. 2015

Excipient Applications in Formulation Design and Drug Delivery

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Moisture sensitivity of active pharmaceutical ingredients (APIs) presents a formidable challenge in the formulation of oral dosage forms. The interaction of moisture with APIs is crucial to an understanding of water-based processes, e.g. manufacturing or prediction of solid dosage form stability and shelf-life. Unwarranted moisture sorption by either APIs or excipients can result in unstable oral solid formulations. The appropriate selection of excipients for the core formulation and appropriate moisture barrier film coating helps to remedy the moisture-related issues with APIs and thus can improve the storage stability of the final formulations. In this chapter, we review the nature and extent of the moisture sensitivity and possible approaches taken to overcome it. Use of excipients that bind tightly with water reduce its potential interaction with the API. In addition, application of a barrier coating to reduce rate and extent of moisture ingress into the core of the solid dosage form during the storage (in original packaging or while in-use), are some of the many simple options that have been considered and described.Keywords Calorimetry · Degradation · Differential scanning calorimetry · Dynamic vapor sorption · Equilibrium relative humidity · Excipients · Isothermal microcalorimetry · Moisture · Moisture-barrier coating · Near-infra red Spectroscopy · Opadry · Optical waveguide spectroscopy · Packaging · Stability · Water · Water vapor transmission rate Abbreviations AluAluminum API Active pharmaceutical ingredient

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Effect of Silica Gel on Stability and Biological Availability of Ascorbic Acid

Cited by 26 publications

References 7 publications

Uv-Vis, NMR and Ft-Ir Spectra of Tautomers of Vitamin C. Experimental and DFT Calculations

Uv-Vis, NMR and Ft-Ir Spectra of Tautomers of Vitamin C. Experimental and DFT Calculations

Hygroscopicity of a sugarless coating layer formed by the interaction between mannitol and poly(vinyl alcohol) (PVA)

Excipient Selection in Oral Solid Dosage Formulations Containing Moisture Sensitive Drugs

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