Effect of Silver Nanoparticle-Mediated Wound Therapy on Biochemical, Hematological, and Histological Parameters

Chauhan, Pallavi; Shrivastava, Vikas; Prasad, Gbks; Tomar, Rajesh Singh

doi:10.22159/ajpcr.2018.v11i3.23531

Cited by 8 publications

(5 citation statements)

References 45 publications

(46 reference statements)

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“…The results obtained showed efficient wound healing potential of silver nanoparticles as compared to pre-existing drug povidone-iodine, i.e., the percentage reduction in wound area after therapy was 100% on day 14 th day in case of biosynthesized silver nanoparticle(CPAgNP) treated group, 92.39% reduction in AECPL treatment group, 95.89% reduction in case of povidone-iodine-treated animals, 80.67% reduction in case of diabetic control group (diabetic) and 87.67% reduction in healthy control group (non-diabetic). Chauhan et al, (2018) also reported efficient wound healing (96.9%) potential of biosynthesized silver nanoparticles as compared to drug povidone-iodine (64.28%).…”

Section: Wound Healing Measurementsmentioning

confidence: 86%

Effect on Healing Potential of Biosynthesized Silver Nanoparticles in Streptozotocin induce Diabetic Rat Wound Model

Chandnani¹,

Roy²,

Sannat³

et al. 2022

IJAR

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Background: Diabetes mellitus is a complex chronic condition that results in hyperglycemic environment affecting the metabolism of proteins and lipids, promotes inflammation and delays wound healing. Methods: A total of n=30 Wistar rats of either sex were divided into five groups with 6 animals in each. Diabetes mellitus was induced using streptozotocin @ 35 mg/kg body weight and excision wound model was developed in all the animals. Group I and Group II were considered as healthy and diabetic control group respectively. The wounds of Group III, IV and V were treated with topical application of Carica papaya synthesized silver nanoparticles @ 62.5 µg/ml, Carica papaya leafextract @ 31.25 mg/ml and 10% povidone iodine respectively. Result: Present study concluded that the characteristics of silver nanaoparticles synthesized form C. papaya leaf extract make them suitable for the treatment of wound healing in diabetic subjects.

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Section: Wound Healing Measurementsmentioning

confidence: 86%

Effect on Healing Potential of Biosynthesized Silver Nanoparticles in Streptozotocin induce Diabetic Rat Wound Model

Chandnani¹,

Roy²,

Sannat³

et al. 2022

IJAR

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“…Further the hematological parameters such as hct, PLT, RBC, WBC count etc. did not have much variation during Ag NP application [79]. Plant based nanoparticles can also control the inflammatory response by downregulating TNF-α, IL-6, IL-1β, and IL-10 synthesis by the cells and sometimes can control inflammatory pathways by inhibiting NF-kB [53].…”

Section: Green Synthesized Nanoparticlesmentioning

confidence: 96%

Strategies of Nanomaterial Application for Enhanced Wound Curing: An Overview

Nag¹,

Lahiri²,

Dash³

et al. 2021

Nano BioMed ENG

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& Management Kolkata, West Bengal. Her research interests include antimicrobial peptides and drug development. Dr. Nag has published many research papers in various peer reviewed national and international journals. Dibyajit Lahiri working as Assistant Professor at University of engineering & Management Kolkata His Research work focus on antibiofilm and antimicrobial studies of various bioactive compounds and their subsequent use as an alternative to antibiotics. He has many publications in international and national journal of repute. Sudipta Dash has recently graduated from University of Engineering & Management, Kolkata, with Bachelor of Technology in Biotechnology. His research interest includes (but not limited to) bioinspired nanomaterial synthesis, antimicrobial studies, enzyme purification and cell regeneration-based works. He published his research work in a number of peer reviewed journals. Dipro Mukherjee is pursuing his B.Tech in Biotechnology.

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“…In 2017, Peng et al reported that the surface stabilization of NPs with low molecular weight stabilizers decreased the absorption characteristics in the body, making it less toxic in an MRSA-infected mouse wound model [ 229 ]. Likewise, the biosynthesis of NPs has showcased on repeated occasions its non-toxic abilities without losing its antibacterial, antibiofilm and wound-healing integrity [ 169 , 230 , 231 ]. As nanoengineering is itself an evolutionary process that requires the amalgamation of several subunits, there is always room for improving the mode of application.…”

Section: Nanotechnology In Regenerationmentioning

confidence: 99%

Engineered Nanotechnology: An Effective Therapeutic Platform for the Chronic Cutaneous Wound

et al. 2022

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The healing of chronic wound infections, especially cutaneous wounds, involves a complex cascade of events demanding mutual interaction between immunity and other natural host processes. Wound infections are caused by the consortia of microbial species that keep on proliferating and produce various types of virulence factors that cause the development of chronic infections. The mono- or polymicrobial nature of surface wound infections is best characterized by its ability to form biofilm that renders antimicrobial resistance to commonly administered drugs due to poor biofilm matrix permeability. With an increasing incidence of chronic wound biofilm infections, there is an urgent need for non-conventional antimicrobial approaches, such as developing nanomaterials that have intrinsic antimicrobial-antibiofilm properties modulating the biochemical or biophysical parameters in the wound microenvironment in order to cause disruption and removal of biofilms, such as designing nanomaterials as efficient drug-delivery vehicles carrying antibiotics, bioactive compounds, growth factor antioxidants or stem cells reaching the infection sites and having a distinct mechanism of action in comparison to antibiotics—functionalized nanoparticles (NPs) for better incursion through the biofilm matrix. NPs are thought to act by modulating the microbial colonization and biofilm formation in wounds due to their differential particle size, shape, surface charge and composition through alterations in bacterial cell membrane composition, as well as their conductivity, loss of respiratory activity, generation of reactive oxygen species (ROS), nitrosation of cysteines of proteins, lipid peroxidation, DNA unwinding and modulation of metabolic pathways. For the treatment of chronic wounds, extensive research is ongoing to explore a variety of nanoplatforms, including metallic and nonmetallic NPs, nanofibers and self-accumulating nanocarriers. As the use of the magnetic nanoparticle (MNP)-entrenched pre-designed hydrogel sheet (MPS) is found to enhance wound healing, the bio-nanocomposites consisting of bacterial cellulose and magnetic nanoparticles (magnetite) are now successfully used for the healing of chronic wounds. With the objective of precise targeting, some kinds of “intelligent” nanoparticles are constructed to react according to the required environment, which are later incorporated in the dressings, so that the wound can be treated with nano-impregnated dressing material in situ. For the effective healing of skin wounds, high-expressing, transiently modified stem cells, controlled by nano 3D architectures, have been developed to encourage angiogenesis and tissue regeneration. In order to overcome the challenge of time and dose constraints during drug administration, the approach of combinatorial nano therapy is adopted, whereby AI will help to exploit the full potential of nanomedicine to treat chronic wounds.

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Effect of Silver Nanoparticle-Mediated Wound Therapy on Biochemical, Hematological, and Histological Parameters

Cited by 8 publications

References 45 publications

Effect on Healing Potential of Biosynthesized Silver Nanoparticles in Streptozotocin induce Diabetic Rat Wound Model

Effect on Healing Potential of Biosynthesized Silver Nanoparticles in Streptozotocin induce Diabetic Rat Wound Model

Strategies of Nanomaterial Application for Enhanced Wound Curing: An Overview

Engineered Nanotechnology: An Effective Therapeutic Platform for the Chronic Cutaneous Wound

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