Effect of silver on burn wound infection control and healing: Review of the literature

Atiyeh, Bishara S.; Costagliola, M; Hayek, Shady N.; Dibo, Saad

doi:10.1016/j.burns.2006.06.010

Cited by 1,098 publications

(797 citation statements)

References 70 publications

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“…While the mode of action of silver is not fully elucidated it has been shown to inactivate NADH and succinate dehydrogenase and so interfere with electron transfer in respiration (Park et al 2009). Exposure to silver may also lead to the generation of reactive oxygen species (ROS) which induces protein and DNA degradation (Park et al 2009;Atiyeh et al 2007;Castellano et al 2007). Previous work demonstrated the induction of an oxidative stress response in C. albicans when exposed to Ag(I) ions (Rowan et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Assessment of in vivo antimicrobial activity of the carbene silver(I) acetate derivative SBC3 using Galleria mellonella larvae

et al. 2014

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The antimicrobial drug candidate 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene silver(I) acetate (SBC3) was evaluated for its ability to function in vivo using larvae of Galleria mellonella. A SBC3 concentration of 25 lg/ml inhibited the growth of Staphylococcus aureus by 71.2 % and Candida albicans by 86.2 % in vitro. Larvae inoculated with 20 ll of SBC3 solution showed no ill effects up to a concentration of 250 lg/ml but administration of 500 lg/ml resulted in a 40 % reduction in larval survival and administration of a dose of 1,000 lg/ml resulted in total larval death at 24 h. Larvae inoculated with S. aureus or C. albicans and subsequently administered SBC3 showed increased survival. Administration of SBC3 to larvae did not boost the insect immune response as indicated by lack of an increase in the density of circulating haemocytes (immune cells). The abundance of a number of proteins involved in the insect immune response was reduced in larvae that received 20 ll SBC3 solution of 100 lg/ml. This is the first demonstration of the in vivo activity of SBC3 against S. aureus and C. albicans and demonstrates that SBC3 does not stimulate a non-specific immune response in larvae.

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Section: Discussionmentioning

confidence: 99%

Assessment of in vivo antimicrobial activity of the carbene silver(I) acetate derivative SBC3 using Galleria mellonella larvae

et al. 2014

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“…The beneficial effects include: 1-antimicrobial activity 2-beneficial effects on the wound bed [10][11][12]. Silver-based technologies added benefits by down-regulating tissue inhibitors of metalloproteinase to levels that facilitate wound healing [10].the results of several studies suggest that nanocrystalline silver specifically may play a role in altering or compressing the inflammatory events in wounds and facilitating the early phases of wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…Silver-based technologies added benefits by down-regulating tissue inhibitors of metalloproteinase to levels that facilitate wound healing [10].the results of several studies suggest that nanocrystalline silver specifically may play a role in altering or compressing the inflammatory events in wounds and facilitating the early phases of wound healing. These benefits are associated with reduced local matrix metalloproteinase levels and enhanced cellular apoptosis [12,13]. 3-Zinc metabolism was up regulated, implying increases epithelialization [14,15].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Burn Wound Healing Properties of Saline-Soaked Dressing and Silver Sulfadiazine in Rats

2010

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The purpose of this study was to further investigate that phenomenon and to explore the effect silver sulfadiazine on wound healing. Full-thickness burn wounds were created on the dorsum of Wistar albino rats under anesthesia. The wounds were treated with silver sulfadiazine and saline-soaked dressing for fourteen days, and then observed until healed. Wound surface area was measured each three days. Time to 50% and 90% healing was compared. No clinical infections occurred. Wound half-life and healing times were shortest in the saline-soaked group (P<0.0001) in full-thickness burns. Wound contraction was delayed by silver sulfadiazine. These data suggest that silver sulfadiazine retard burn wound healing. Infection control without delay of burn wound healing is most appealing and clinical trials are planned.

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“…Ag(I) ions interact with thiol groups of the L-cysteine residue of proteins (Park et al 2009;Cortese-Krott et al 2009;Atiyeh et al 2007;Castellano et al 2007). This inactivates enzymatic functions involved in the respiratory chain such as NADH and succinate dehydrogenase which can impede electron transfer (Park et al 2009).…”

Section: Introductionmentioning

confidence: 99%

“…This inactivates enzymatic functions involved in the respiratory chain such as NADH and succinate dehydrogenase which can impede electron transfer (Park et al 2009). Another mechanism of action involves the generation of reactive oxygen species (ROS) (Park et al 2009;Cortese-Krott et al 2009) which induces oxidative stress (Park et al 2009) and leads to protein and DNA degradation (Park et al 2009;Atiyeh et al 2007;Castellano et al 2007). Exposing the yeast Candida albicans to Ag(I) ions activates the Cap1p and Hog1p pathways as a consequence of oxidative and/or osmotic stress (Rowan et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Exposure of Staphylococcus aureus to silver(I) induces a short term protective response

et al. 2012

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The Ag(I) ion has well established antibacterial and antifungal properties. Exposure of Staphylococcus aureus to MIC 80 AgNO 3 (3 lg/ml) lead to an increase in the activity of superoxide dismutase, glutathione reductase and catalase at 30 min but activity declined by 60 min. In addition, exposure of cells to this metal ion for 1 h lead to increased expression of a number of proteins such as elongation factors Ts, Tu and G, fructose-bisphosphate aldolase and triosephosphate isomerase but their expression declined following 4 h exposure. ATP binding cassette transporter protein and oligoendopeptidase F showed increased expression at 4 h. While Ag(I) is a potent antimicrobial agent this work demonstrates that S. aureus can mount a short-term protective response to exposure to the metal ion but that this is eventually overcome.

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Effect of silver on burn wound infection control and healing: Review of the literature

Cited by 1,098 publications

References 70 publications

Assessment of in vivo antimicrobial activity of the carbene silver(I) acetate derivative SBC3 using Galleria mellonella larvae

Assessment of in vivo antimicrobial activity of the carbene silver(I) acetate derivative SBC3 using Galleria mellonella larvae

A Comparative Study of the Burn Wound Healing Properties of Saline-Soaked Dressing and Silver Sulfadiazine in Rats

Exposure of Staphylococcus aureus to silver(I) induces a short term protective response

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