Effect of simple analgesics on quantitative sensation test threshold

Abstract

Twenty individuals underwent quantitative sensation testing (QST) before and after 1 dose of aspirin, acetaminophen, or acetaminophen with codeine to determine the effect of analgesics on QST results. There was no significant change from baseline when mean QST results after placebo were compared to mean QST results after analgesics. We conclude that the effect of small doses of simple analgesics on QST results is either not present or is too small to necessitate withholding analgesics before sensory testing.

Pain Hypervigilance is Associated with Greater Clinical Pain Severity and Enhanced Experimental Pain Sensitivity Among Adults with Symptomatic Knee Osteoarthritis

“…We also did not control for the use of non-opioid analgesics in the present investigation. Although this likely did not influence experimental pain sensitivity (46), it is possible the use of non-opioid analgesics may have affected reports of clinical pain and disability. In addition, although we screened for a number of comorbid conditions (see Methods section), we also acknowledge that other comorbidities were not systematically assessed and may have contributed to our findings.…”

Pain Catastrophizing and Anxiety are Associated With Heat Pain Perception in a Community Sample of Adults With Chronic Pain

“…38, 39 40 Previous studies suggest central pain processing, distinct from peripheral nociceptive input, may be responsible for mediating the effects anxiety has on pain perception. 41,42 For example, patients with chronic low back pain who had previously been exposed to a psychologically traumatic event reported higher anxiety, greater use of pain medications, and demonstrated hyperalgesia to deep pain modalities in both that nonsteroidal anti-inflammatory drugs and acetaminophen have no effect on HP perception, 51 but the effects gabapentinoids (ie, pregabalin, gabapentin), 52-54 tricyclic antidepressants (ie, desipramine), 55 and local anesthetics (topical lidocaine, oral mexiletine) are mixed. 56,57 In conclusion, the findings of this study extend the use of a standardized method for assessing HP in a sample of community-dwellings adults with chronic pain.…”

Subclinical Sensory Abnormalities in Trigeminal Neuralgia

“…Chronic drug intake could be suspected to induce sensory threshold elevation in these patients, although Wang et al. studied the effect of analgesic drugs on QST but failed to find significant differences compared with placebo (10). While anti‐epileptic drugs may cause mild neuropathy, it seems unlikely that a systemic drug can specifically affect a nerve, as our symptomatic patients showed more hypoaesthesia in involved branches, Furthermore, drug‐induced polyneuropathy is usually distal and, particularly when axial nerves are affected, may prove severe.…”