Effect of Simulated Geomagnetic Activity on Myocardial Ischemia/Reperfusion Injury in Rats

Abstract

ObjectiveTo study the response of myocardial ischemia/reperfusion injury (MI/RI) in rats to simulated geomagnetic activity.MethodsIn a simulated strong geomagnetic outbreak, the MI/RI rat models were radiated, and their area of myocardial infarction, hemodynamic parameters, creatine kinase (CK), lactate dehydrogenase (LDH), melatonin, and troponin I values were measured after a 24-hour intervention.ResultsOur analysis indicates that the concentrations of troponin I in the geomagnetic shielding+operation group were lower than in the radiation+operation group (P<0.05), the concentrations of melatonin in the shielding+operation group and normal+operation group were higher than in the radiation + operation group (P<0.01), and the concentrations of CK in the shielding + operation group were lower than in the radiation + operation group and normal + operation group (P<0.05). Left ventricular developed pressure (LVDP) and ± dP/dtmax in the radiation+operation group were lower than in the shielding + operation group and normal+operation group (P<0.01). Left ventricular end-diastolic pressure (LEVDP) in the shielding + operation group was higher than in the normal + operation group (P<0.05). There was no significant difference in area of myocardial infarction and LDH between the shielding + operation group and the radiation + operation group.ConclusionOur data suggest that geomagnetic activity is important in regulating myocardial reperfusion injury. The geomagnetic shielding has a protective effect on myocardial injury, and the geomagnetic radiation is a risk factor for aggravating the cardiovascular and cerebrovascular diseases.

Geomagnetic activity affects animal myocardial ischemia/reperfusion injury: an experimental-simulated study

“…The GMA platform used in this study has been reported in previous studies from our group and certified by a Chinese patent no. ZL201520208744.2 (Wu et al 2019 ). Four separate parts make up this geomagnetic experimental platform, i.e., a metal shielding experiment cage, a radiation antenna, a programmable signal generator, and a control computer.…”

“…The MI/RI paradigm was developed as our group has previously explained (Wu et al 2019 ). Using a heated surgical table, the rats’ body temperatures were kept at 37 °C following anesthesia with 2% isoflurane.…”

“…In a previous work, we designed and established a simulated geomagnetic environment to transform GMA into a controllable experimental condition that is not affected by external factors (Wu et al 2019 ). We performed an animal experiment and determined the effect of various GMA on MI/RI in rat models (Van Camp 2014 ).…”

Correlation between ST-elevation myocardial infarction, non-ST-elevation myocardial infarction and the local Earth’s magnetic field changes

“…It affects heart rate variability, increased blood viscosity, coagulation, and platelet aggregation [7]. In an artificially simulated magnetic field experiment with laboratory mice, the difference in myocardial ischemiareperfusion injury was observed depending on different magnetic field conditions [8]. The study revealed that myocardial ischemia-reperfusion injury was greater in mice exposed to an artificial geomagnetic field than in those isolated from the magnetic field [8].…”