Effect of single-dose locally applied lactoferrin on autograft healing in peri-implant bone in rat models

Koca, Cansu Gül; Yıldırım, Bengisu; Özmen, Özlem; Dikilitaş, Ahu; Cicek, Muhammed Fatih; Şimşek, Aysıla Tekeli; Güngör, Mehmet Ali̇

doi:10.1016/j.injury.2021.11.065

Cited by 4 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lf is also used as a non-viral vector to deliver anti-cancer and anti-bacterial drugs for targeted therapeutic purposes. Currently researchers are investigating the role of Lf in post-operative infections such as organ transplants, prosthetic fittings, and skin grafts ( 99 – 102 ). Transgenic cows and goats are also being tried to produce recombinant hLf on a large-scale.…”

Section: Discussion and Prospectmentioning

confidence: 99%

Lactoferrin: A glycoprotein that plays an active role in human health

Cao

Ren

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

Lactoferrin (Lf), existing widely in human and mammalian milk, is a multifunctional glycoprotein with many functions, such as immune regulation, anti-inflammation, antibacterial, antiviral, and antioxidant. These extensive functions largely attribute to its ability to chelate iron and interfere with the cellular receptors of pathogenic microorganisms and their hosts. Moreover, it is non-toxic and has good compatibility with other supplements. Thus, Lf has been widely used in food nutrition, drug carriers, biotechnology, and feed development. Although Lf has been continuously explored and studied, a more comprehensive and systematic compendium is still required. This review presents the recent advances in the structure and physicochemical properties of Lf as well as clinical studies on human diseases, with the aim of providing a reference for further research of Lf and the development of its related functional products.

show abstract

Section: Discussion and Prospectmentioning

confidence: 99%

Lactoferrin: A glycoprotein that plays an active role in human health

Cao

Ren

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…Micro-CT analysis revealed that bone volume was the highest in the 85 mg/kg body weight group. Koca et al investigated whether LF was beneficial for autograft healing in peri-implant bone in a rat model [29]; the percentage of bone volume (bone volume/total volume) in the micro-CT analysis was significantly higher in the defect filled with autograft and LF (100 µg/mL) group compared with that in the autograft-only group. Thus, TA-MSN-LF conclusively induces bone tissue formation and spinal regeneration.…”

Section: Discussionmentioning

confidence: 99%

Lactoferrin-Anchored Tannylated Mesoporous Silica Nanomaterials-Induced Bone Fusion in a Rat Model of Lumbar Spinal Fusion

Noh,

Sung,

Byeon

et al. 2023

IJMS

View full text Add to dashboard Cite

Lactoferrin (LF) is a potent antiviral, anti-inflammatory, and antibacterial agent found in cow and human colostrum which acts as an osteogenic growth factor. This study aimed to investigate whether LF-anchored tannylated mesoporous silica nanomaterials (TA-MSN-LF) function as a bone fusion material in a rat model. In this study, we created TA-MSN-LF and measured the effects of low (1 μg) and high (100 μg) TA-MSN-LF concentrations in a spinal fusion animal model. Rats were assigned to four groups in this study: defect, MSN, TA-MSN-LF-low (1 μg/mL), and TA-MSN-LF-high (100 μg/mL). Eight weeks after surgery, a greater amount of radiological fusion was identified in the TA-MSN-LF groups than in the other groups. Hematoxylin and eosin staining showed that new bone fusion was induced in the TA-MSN-LF groups. Additionally, osteocalcin, a marker of bone formation, was detected by immunohistochemistry, and its intensity was induced in the TA-MSN-LF groups. The formation of new vessels was induced in the TA-MSN-LF-high group. We also confirmed an increase in the serum osteocalcin level and the mRNA expression of osteocalcin and osteopontin in the TA-MSN-LF groups. TA-MSN-LF showed effective bone fusion and angiogenesis in rats. We suggest that TA-MSN-LF is a potent material for spinal bone fusion.

show abstract

Nanoparticular and other carriers to deliver lactoferrin for antimicrobial, antibiofilm and bone-regenerating effects: a review

2022

View full text Add to dashboard Cite

Bone and joint infections are a rare but serious problem worldwide. Lactoferrin’s antimicrobial and antibiofilm activity coupled with its bone-regenerating effects may make it suitable for improving bone and joint infection treatment. However, free lactoferrin (LF) has highly variable oral bioavailability in humans due to potential for degradation in the stomach and small intestine. It also has a short half-life in blood plasma. Therefore, encapsulating LF in nanocarriers may slow degradation in the gastrointestinal tract and enhance LF absorption, stability, permeability and oral bioavailability. This review will summarize the literature on the encapsulation of LF into liposomes, solid lipid nanoparticles, nanostructured lipid carriers, polymeric micro and nanoparticles and hydroxyapatite nanocrystals. The fabrication, characterization, advantages, disadvantages and applications of each system will be discussed and compared.

show abstract

Effect of single-dose locally applied lactoferrin on autograft healing in peri-implant bone in rat models

Cited by 4 publications

References 34 publications

Lactoferrin: A glycoprotein that plays an active role in human health

Lactoferrin: A glycoprotein that plays an active role in human health

Lactoferrin-Anchored Tannylated Mesoporous Silica Nanomaterials-Induced Bone Fusion in a Rat Model of Lumbar Spinal Fusion

Nanoparticular and other carriers to deliver lactoferrin for antimicrobial, antibiofilm and bone-regenerating effects: a review

Contact Info

Product

Resources

About