Effect of single or repeated formaldehyde exposure on minute volume of B6C3F1 mice and F-344 rats*1

Chang, Jane; Steinhagen, William H.; Barrow, Craig S.

doi:10.1016/0041-008x(81)90368-9

Cited by 114 publications

(47 citation statements)

References 18 publications

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“…The contribution of this respiratory CR to sensitization is apparent in experiments that altered environmental cues. The results of such experiments suggest that sensitization is apparent only when animals are repeatedly exposed to formaldehyde in the environment in which the respiratory measurements were made (13,16,17 (18).…”

Section: Sensitization To Irritants As a Learned Responsementioning

confidence: 88%

Pavlovian Conditioning and Multiple Chemical Sensitivity

Siegel¹,

Kreutzer²

1997

Environmental Health Perspectives

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Pavlovian conditioning processes may contribute to some symptoms of multiple chemical sensitivity (MCS). This review summarizes the potential relevance of the literature on conditional taste and olfactory aversions, conditional sensitization, and conditional immunomodulation to understanding MCS. A conditioning-based perspective on MCS suggests novel research and treatment strategies. -Environ Health Perspect 1 05(Suppl 2): 521-526 (1997)

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Section: Sensitization To Irritants As a Learned Responsementioning

confidence: 88%

Pavlovian Conditioning and Multiple Chemical Sensitivity

Siegel¹,

Kreutzer²

1997

Environmental Health Perspectives

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“…Exposure to the pulmonary irritant O 3 induces a reflex shift in breathing pattern to rapid and shallow respiration (Lee et al, 1979;McDonnell et al, 1983). Formaldehyde, however, is an upper-airway irritant (Alarie, 1973;Kane and Alarie, 1977) and induces reflex depression of breathing frequency and minute ventilation by up to 30-50% of control in resting exposures of rats and mice to 7-15 ppm HCHO (Chang et al, 1981;Jaeger and Gearhart, 1982). Such depression of ventilation will reduce the inhaled dose of O 3 in an exposure to the mixture, and a shift in breathing pattern and possible increase in respiratory resistance (Amdur, 1960), could further affect the distribution of inhaled O 3 in the lungs.…”

Section: Discussionmentioning

confidence: 99%

Effects of exercise exposure on toxic interactions between inhaled oxidant and aldehyde air pollutants

Mautz

Kleinman

Phalen

et al. 1988

Journal of Toxicology and Environmental Health

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“…Sensitization that results from repeated exposures to an irritant may have Pavlovian components that may even result in conditioned allergic reactions. In experimental models, sensitivity to airborne irritants such as formaldehyde has been conditioned (Chang, Steinhagen, & Barrow, 1981;Song, Tschirgi, Swindell, Chen, & Fang, 2001). By virtue of being paired with an irritant, a previously benign stimulus will elicit the same response as the chemical itself (Alarie, 1966).…”

Section: Pavlovian or Classically Conditioned Behaviormentioning

confidence: 99%

Environmental health and behavior analysis: Contributions and interactions.

Newland¹

2013

APA Handbook of Behavior Analysis, Vol. 2: Translating Principles Into Practice.

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The heightened public awareness that environmental contaminants can act on the nervous system and have effects that appear in behavior presents a major challenge to behavioral scientists in all areas. They are being asked to conduct both hazard assessment (are there neurobehavioral effects of some chemical at any dose?) and risk assessment (what is the risk to a population at a specific level of exposure?) for behavioral effects that are not always well understood. The heavy metal lead provides an excellent example. Concern over lead poisoning lies in claims that it lowers scores on IQ tests, retards academic performance, and results in disruptive and even criminal behavior. The problems posed are daunting: How easy is it to detect a 5-point drop in scores on IQ tests? Can scientists predict these effects from experimental models using laboratory animals? Can they identify behavioral and neural mechanisms that account for these effects? What economic costs are incurred if the average IQ drops a few points, and how does this cost compare with that of reducing lead in the environment?These concerns are reflected in policymaking. Federal legislation and regulation of toxic substances specifically include behavior, including schedule-controlled operant behavior, as a regulatory endpoint (Tilson, 1990). The inclusion of nervous system damage in general, and its behavioral manifestations in particular, represents a sea change in public concern over unintended exposure to chemicals. Where cancer has been (and still is) a significant concern, the recognition that adverse behavioral effects follow certain types of chemical exposure is increasing. These effects carry over into a large number of domains. Environmental contaminants, even at very low exposure levels, contribute to disorders across the life span, including developmental disabilities and the hastening of age-related impairments. Behavioral scientists' understanding of how this happens not only has public policy implications but can also inform them about the behavior and neurobiology surrounding these disorders.

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Effect of single or repeated formaldehyde exposure on minute volume of B6C3F1 mice and F-344 rats*1

Cited by 114 publications

References 18 publications

Pavlovian Conditioning and Multiple Chemical Sensitivity

Pavlovian Conditioning and Multiple Chemical Sensitivity

Effects of exercise exposure on toxic interactions between inhaled oxidant and aldehyde air pollutants

Environmental health and behavior analysis: Contributions and interactions.

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