2023
DOI: 10.1111/jvim.16650
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Effect of sirolimus on insulin dynamics in horses

Abstract: Background Sirolimus, a mechanistic target of rapamycin inhibitor, suppresses insulin production in other species and has therapeutic potential for hyperinsulinemia in horses. Hypothesis/Objective Determine the pharmacokinetics (PKs) of sirolimus and evaluate its effect on insulin dynamics in healthy and insulin dysregulation (ID) horses. Animals Eight Standardbred geldings. Methods A PK study was performed followe… Show more

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