Effect of Six Months Lifestyle Intervention in Japanese Men with Metabolic Syndrome: Randomized Controlled Trial

Abstract

215Akiko NANRI, et al.: Lifestyle Intervention and Metabolic Syndrome decreased. Conclusions: Although the tailor-made lifestyle modification program among men with MS did not provide an additional benefit in decreasing the prevalence of MS, it may help weight control and improve glucose metabolism. (J Occup Health 2012; 54: 215-222) Key words: Intervention, Lifestyle, Metabolic syndrome Metabolic syndrome (MS), which consists of abdominal obesity, hypertension, hyperglycemia and hyperlipidemia, is associated with increased risk of type 2 diabetes and cardiovascular disease. The prevalence of MS has been remarkably increasing worldwide over the past two decades 1) . In Japan, in particular, the prevalence of MS was 26.9% for adult men and 9.9% for adult women in 2007 2) . Therefore, an effective strategy against MS is urgently needed.Lifestyle modification against overweight, physical inactivity and an atherogenic diet have been recommended as a foundation for management of MS 1). A few controlled-intervention studies among subjects with MS have examined the effect of lifestyle intervention. In a Korean study among subjects with MS 3) , the prevalence of MS did not significantly differ between intervention and control groups after six months. On the other hand, in an Italian study among subjects with MS and those who had two MS components and a high level of high-sensitivity C-reactive protein (hs-CRP) 4) , the intervention group showed a significantly greater reduction in the prevalence of MS than the control group. In some Japanese studies, lifestyle intervention in adults who had an unfavorable profile in terms of cardiometabolic risk factors 5-7) has been shown to improve components of MS. To our knowledge, however, no study has examined the effect of intervention among subjects who met the Japanese definition of MS in Japan. Department of Epidemiology and Prevention, International Clinical Research Center, National Center for Global Health and Medicine-Objectives:The prevalence of metabolic syndrome (MS) has been remarkably increasing worldwide. However, few studies have examined the effect of lifestyle intervention among subjects with MS. We investigated the effect of a sixmonth lifestyle modification program on the prevalence of MS and its associated biomarkers among Japanese men with MS. Methods: Subjects were randomly assigned to either the intervention (n=53) or control (n=54) group. Subjects in the intervention group received a lifestyle modification program focused on exercise and diet behavior from a trained occupational health nurse at the baseline and at one and three months. The effect of intervention was assessed by differences in changes in the prevalence of MS, its components and associated biomarkers between the two groups. Results: Of the 107 participants, 102 completed the survey at the end of six months (intervention group, n=49; control group, n=53). During the study period, the prevalence of MS decreased to 65.3% and 62.3% in the intervention group and control group, respectively....

Effects of a Community-Based Healthy Lifestyle Intervention Program (Co-HELP) among Adults with Prediabetes in a Developing Country: A Quasi-Experimental Study

“…We are also aware that there were lack of objective measurements on physical activity and dietary intake. However, self-reported questionnaires on physical activity and diet have also been used in other intervention trials [56, 63, 64] and were found to be reliable. The distance between both communities was approximately seven kilometres and the possibility that contamination occurred between the intervention and control groups cannot be ruled out.…”

Promoting Physical Activity and Healthy Dietary Behavior

“…independently evaluated the methodological quality of the studies by using an existing checklist ( Table 2). [13][14][15][16][17][18][19][20][21][22][23][24][25] Concerning the methodological quality assessment, the authors (L.K. 12 The checklist contains 12 criteria for internal validity that are related to selection bias (2 items), performance bias (3 items), attrition bias (2 items), and detection bias (5 items).…”

“…Most interventions were aimed at men and women with specific risk factors, including unhealthy physical activity and/or dietary behaviors, overweight, high cholesterol levels, high fasting glucose, and large waist circumferences. 23,26 Eight of the 14 studies conducted a randomized controlled trial (RCT), [14][15][16][17]19,21,22,25 4 a controlled trial, 18,20,23,26 and 2 noncontrolled studies. [15][16][17]19 The number of participants ranged from 68 to 1393.…”

“…[15][16][17]19 The number of participants ranged from 68 to 1393. [15][16][17]19,21,22,25 One RCT 14 and three of the four controlled trials 20,23,26 were graded as fair-quality studies. 23,26 Eight of the 14 studies conducted a randomized controlled trial (RCT), [14][15][16][17]19,21,22,25 4 a controlled trial, 18,20,23,26 and 2 noncontrolled studies.…”

“…[14][15][16][17]21,22 Counseling varied greatly in duration, frequency, and methods used. 14 Sessions were given both face-to-face and by telephone and were performed by an occupational nurse (ON), [14][15][16][17]19 occupational physician (OP), [15][16][17]21,22 dietician, 18 or health promotion staff. 14 Sessions were given both face-to-face and by telephone and were performed by an occupational nurse (ON), [14][15][16][17]19 occupational physician (OP), [15][16][17]21,22 dietician, 18 or health promotion staff.…”