Effect of sleeve gastrectomy on plasma growth differentiation factor-15 (GDF15) in human

Dolo, Ponnie Robertlee; Yao, Libin; Liu, Peng Peng; Widjaja, Jason; Meng, Shaoping; Li, Chao; Zhu, Xiaoping

doi:10.1016/j.amjsurg.2020.01.041

Cited by 20 publications

(19 citation statements)

References 27 publications

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“…To further analyze the consistence of the studies, we compared the results of the present study with the results of previous intervention studies. Interestingly, in some previous studies patients with baseline GDF15 levels below 900 pg/ml had their GDF15 levels signi cantly increased after intervention [8,11,12], while in other studies patients with baseline GDF15 levels above 900 pg/ml had their GDF15 levels remained unchanged or signi cantly decreased after intervention [22][23][24]. Based on our and previous research results, we preliminarily speculated that in the process of metabolic improvement, the GDF15 levels either increased or remained unchanged when baseline GDF15 levels were < 900 pg/ml, and either decreased or remained unchanged when baseline GDF15 levels were ≥ 900 pg/ml.…”

Section: Discussionmentioning

confidence: 93%

“…We also rstly investigated the relationship between the improvement of clinical metabolic parameters and baseline GDF15 levels, and found that in patients with baseline GDF15 levels ≥ 900 pg/ml, better metabolic improvement could be obtained under the a 4-week LI. However, in the process of metabolic improvement, different change trends of circulating GDF15 levels were reported in different studies [8,11,12,[22][23][24]. At present, the causal relationship and mechanisms between the change of GDF15 levels and the improvement of metabolism are still unclear, which need to be further explored.…”

Section: Discussionmentioning

confidence: 94%

“…Previous studies have explored the changes of circulating GDF15 levels in T2DM patients with diet intervention, drug intervention or bariatric surgeries, however, the sample sizes were relatively small and the results were not consistent. Several studies [8,11,12] found that the GDF15 levels of obese/T2DM patients (n < 50) signi cantly increased after the bariatric surgery compared with levels before the bariatric surgery (< 500 pg/ml). Two studies [22,23] indicated that a 2-week very low calorie diet (n = 14) or a 6-week high-protein diet (n = 37) did not change the GDF15 levels (> 1000 pg/ml) among patients with T2DM patients.…”

Section: Discussionmentioning

confidence: 99%

“…Crosssectional studies showed that circulating GDF15 levels were signi cantly and positively correlated to insulin resistance [9,10]. However, circulating GDF15 levels further increased when insulin resistance was signi cantly improved in the prospective studies of obese/T2DM patients after bariatric surgeries [8,11,12]. It is not clear whether high GDF15 levels indicate metabolic disorder or metabolic improvement.…”

Section: Introductionmentioning

confidence: 99%

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Decreased Serum Growth Differentiation Factor 15 Levels After Lifestyle Intervention in Patients With Newly Diagnosed Type 2 Diabetes Mellitus

et al. 2020

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Background: Recent studies noted that circulating growth differentiation factor 15 (GDF15) were closely related to metabolic states. The study aimed to explore the changes of GDF15 levels and their influencing factors after 4 weeks of lifestyle intervention (LI) or LI combined with breakfast meal replacement (LI+MR) in newly diagnosed type 2 diabetes patients. Methods: A total of 84 patients with available serum samples at both baseline and Week 4 were enrolled in this biomarker substudy. All subjects underwent a 2-hour 75g oral glucose tolerance test at baseline and Week 4. Serum GDF15 levels were determined by a sandwich enzyme-linked immunosorbent assay. Results: After 4-weeks of LI, GDF15 levels overall significantly decreased compared with baseline (P<0.05). ∆GDF15 levels were significantly and negatively associated with baseline GDF15 levels (r=–0.450, P<0.001). The optimal cut-off point of baseline GDF15 levels for predicting a GDF15 decrease after 4-weeks of LI was 904.57 pg/ml, with an area under curve of 0.699. Based on the cut-off point of 900 pg/ml, patients with baseline GDF15 ≥900 pg/ml had significantly decreased GDF15 levels after LI, while those <900 pg/ml had no significant changes. Regression models showed that baseline GDF15 level was an independent positive factor for the improvement of fasting plasma glucose and homeostasis model assessment for insulin resistance only in patients with baseline GDF15 levels ≥900 pg/ml. Conclusions: LI led to significantly decreased GDF15 levels among patients with newly diagnosed type 2 diabetes and its effect was more significant among patients with baseline GDF15 levels ≥900 pg/ml.Trial registration: ClinicalTrials.gov, NCT02248714. Registered 25 September 2014 - Retrospectively registered, https://www.clinicaltrials.gov/ct2/show/NCT02248714?term=NCT02248714&draw=2&rank=1

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Decreased Serum Growth Differentiation Factor 15 Levels After Lifestyle Intervention in Patients With Newly Diagnosed Type 2 Diabetes Mellitus

et al. 2020

Preprint

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“…We wonder if the lack of an increase in FGF-21 in SG in our study was due to the age of the mice, or whether we missed an early increase in FGF-21 by only testing plasma samples from 2 months after SG. Deletion of Growth Differentiation Factor-15 (GDF-15) was not found to affect food intake or body weight after SG 28 . But in humans, plasma levels of GDF-15 were found to positively correlated with weight loss magnitude 29 .…”

Section: Discussionmentioning

confidence: 99%

Fat Mass Regain in Middle-Aged Mice after Sleeve Gastrectomy is divergent from plasma leptin levels

Emiliano

Higuchi

et al. 2020

Preprint

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BackgroundSome degree of weight regain is typically observed in human patients who undergo Sleeve Gastrectomy (SG), even if the majority of them do not return to their presurgical body weight. Although the majority of bariatric surgery patients are middle aged, most preclinical models of bariatric surgery utilize juvenile male mice. A long-term characterization of the response of mature, wild type, obese male mice to SG has not been performed.MethodsEight-month old C57bl/6J obese male mice were randomized to undergo SG, sham surgery without caloric restriction (SH) or sham surgery with caloric restriction to match body weight to the SG group (SWM). Body weight, body composition and glucose tolerance were matched at baseline. Mice were followed for 60 days following their respective surgeries.ResultsSG mice had a more pronounced percent weight loss than the SH group in the first post-operative month (p<0.05), along with fat mass loss (p<0.01). By the second post-operative month, the SG group started to regain fat mass, although it continued to be statistically lower than the SH group (p<0.05). Cumulative food intake was significantly lower in the SG group compared to SH group only in the first post-operative week (p<0.05), with both groups having similar cumulative food intake thereafter (p>0.05). SWM group had a significantly lower cumulative food intake throughout the study, except for week 1 (p<0.01). Glucose tolerance was only demonstrably better in the SG group compared to SH group at 8 weeks post-operatively (p<0.01). Plasma leptin was significantly lower in the SG group compared to both SWM and SH groups group by the second post-operative month (p<0.01), in spite of SG’s increasing fat mass accumulation. In the second post-operative month, both FGF-21 and GDF-15 were increased in the SH group compared to the SG and SWM groups (p<0.05), while there was no difference in plasma insulin among the three groups. Heat production was surprisingly higher in the SH group compared to the other two groups (p<0.05), even though brown adipose tissue Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Cidea mRNA expression were significantly higher in SG and SWM compared to SH (p<0.01). There was no change in BAT UCP-1 mRNA expression among the groups (p>0.05). There was also no change in fecal lipid content among the groups (p>0.05).ConclusionsSG in obese, middle aged male mice leads is accompanied by fat mass regain in the second post-operative month, while plasma leptin levels continue to be significantly lower. This raises the question of whether the observed fat mass regain consists mostly of visceral adipose tissue.

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GDF15 and Cortisol Response to Meal Tolerance Test in Post-Sleeve Gastrectomy Patients with Weight Regain

et al. 2022

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Effect of sleeve gastrectomy on plasma growth differentiation factor-15 (GDF15) in human

Cited by 20 publications

References 27 publications

Decreased Serum Growth Differentiation Factor 15 Levels After Lifestyle Intervention in Patients With Newly Diagnosed Type 2 Diabetes Mellitus

Decreased Serum Growth Differentiation Factor 15 Levels After Lifestyle Intervention in Patients With Newly Diagnosed Type 2 Diabetes Mellitus

Fat Mass Regain in Middle-Aged Mice after Sleeve Gastrectomy is divergent from plasma leptin levels

GDF15 and Cortisol Response to Meal Tolerance Test in Post-Sleeve Gastrectomy Patients with Weight Regain

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