Effect of small and large animal skull bone on photoacoustic signal

Xu, Qiuyun; Volinski, Bridget; Hariri, Ali; Fatima, Afreen; Avanaki, Kamran

doi:10.1117/12.2254183

Cited by 9 publications

(8 citation statements)

References 19 publications

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“…The figure shows that when the same total optical energy is deposited to the tissue, the penetration depth is greater for the multi-angle illumination than for full-field illumination. The method introduced in this study maybe used for PA transcranial imaging where skull has an aberration effect on the PA signals [33][34][35][36][37][38][39][40].…”

Section: Resultsmentioning

confidence: 99%

Adjustable light illumination for linear array photoacoustic computed tomography

Manwar¹,

Benavides²,

Prakash³

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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Photoacoustic computed tomography (PACT) utilizing a linear array ultrasound transducer that can be handheld is popular in clinical translation. However, in linear array PACT, one of the challenges is achieving homogenous light illumination of structures from the surface through deep structures within biological tissue with limited optical energy. A circular or rectangular optical fiber bundle attached to both sides of the elevation plane of the transducer at a fixed angle provides light delivery in linear array PACT, but this configuration does not provide optimum homogenous illumination. Therefore, it is essential to have accessibility to angular adjustment of the optical beam path to allow photons to create different pathways. Existing methods for implementing various beam paths are not flexible or require precise calibration for any changes in the angle of illumination. In this study, we propose a simple and effective adjustable-angle illumination scheme for linear array-based PACT to create different illumination focal points randomly within the imaging plane. This method, based on an adjustable angular illumination technique while acquiring photoacoustic signals, allows the incident photons to interact with the imaging targets for longer periods of time and diffuse further in all directions. We have investigated the effectiveness of the proposed method by imaging photoacoustic targets in biological tissues ex-vivo and demonstrated that deeper structures can be successfully identified.

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Section: Resultsmentioning

confidence: 99%

Adjustable light illumination for linear array photoacoustic computed tomography

Manwar¹,

Benavides²,

Prakash³

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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“…Using more sensitive ultrasound transducers, a higher number of transducers, faster data acquisition systems, higher energy laser with higher repetition rates (>50 Hz), and a more comfortable transducer-head coupling, a more practical PA system for neonatal brain imaging can be achieved. Finding the optimized wavelength for deep brain imaging, an effective skull aberration compensation algorithm [ 225 , [227] , [228] , [229] ], deconvolving the PA signal generated by the scalp and hair from that generated by the brain, and developing an optimum image reconstruction [ 197 , 198 ] and enhancement algorithms, are other issues to consider in translating PAI from preclinical studies to clinical practice. Due to its low-cost and maintenance compared with fcMRI and PET, the value of fcPAT should reconsidered as a contributor to functional neuroimaging of the newborn.…”

Section: Neuroimaging Modalities For Measuring Resting-state Functionmentioning

confidence: 99%

Neonatal brain resting-state functional connectivity imaging modalities

Mohammadi‐Nejad¹,

Mahmoudzadeh²,

Hassanpour³

et al. 2018

Photoacoustics

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Infancy is the most critical period in human brain development. Studies demonstrate that subtle brain abnormalities during this state of life may greatly affect the developmental processes of the newborn infants. One of the rapidly developing methods for early characterization of abnormal brain development is functional connectivity of the brain at rest. While the majority of resting-state studies have been conducted using magnetic resonance imaging (MRI), there is clear evidence that resting-state functional connectivity (rs-FC) can also be evaluated using other imaging modalities. The aim of this review is to compare the advantages and limitations of different modalities used for the mapping of infants’ brain functional connectivity at rest. In addition, we introduce photoacoustic tomography, a novel functional neuroimaging modality, as a complementary modality for functional mapping of infants’ brain.

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“…This distortion is contributed by four different phenomena: (i) the acoustic attenuation (i.e., the decrease in the acoustic signal amplitude) due to the absorption and scattering of the skull tissue [ 27 , 28 , 29 ]; (ii) the acoustic dispersion (i.e., the dependency of the speed of sound on frequency) modifies the phase of the acoustic wave [ 29 ]; (iii) the signal broadening, which is a frequency-dependent reduction in the acoustic wave amplitude [ 30 ]; and (iv) the temporal shift, where the significantly higher speed of sound in the bone (~2900 m/s [ 31 ]) as compared to the brain’s soft tissue (~1500 m/s [ 32 ]) makes the acoustic waves travel faster through the skull and be detected earlier. The degree of attenuation, dispersion, broadening, and temporal shift are determined by the mechanical properties of the skull (i.e., bone type, density, porosity, and thickness), among which the tissue thickness has the most significant effect [ 33 , 34 , 35 ]. In transcranial photoacoustic imaging, there are two sources of signal attenuation: (1) acoustic, and (2) optical.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study

Manwar

Kratkiewicz

Avanaki

2020

Sensors

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Although transcranial photoacoustic imaging (TCPAI) has been used in small animal brain imaging, in animals with thicker skull bones or in humans both light illumination and ultrasound propagation paths are affected. Hence, the PA image is largely degraded and in some cases completely distorted. This study aims to investigate and determine the maximum thickness of the skull through which photoacoustic imaging is feasible in terms of retaining the imaging target structure without incorporating any post processing. We identify the effect of the skull on both the illumination path and acoustic propagation path separately and combined. In the experimental phase, the distorting effect of ex vivo sheep skull bones with thicknesses in the range of 0.7~1.3 mm are explored. We believe that the findings in this study facilitate the clinical translation of TCPAI.

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Effect of small and large animal skull bone on photoacoustic signal

Cited by 9 publications

References 19 publications

Adjustable light illumination for linear array photoacoustic computed tomography

Adjustable light illumination for linear array photoacoustic computed tomography

Neonatal brain resting-state functional connectivity imaging modalities

Investigation of the Effect of the Skull in Transcranial Photoacoustic Imaging: A Preliminary Ex Vivo Study

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