1949
DOI: 10.2307/4586880
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Effect of Smallpox Vaccination on the Outcome of Pregnancy

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Cited by 45 publications
(6 citation statements)
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“…Apparently it has been generally accepted that pregnancy is not affected by v,accination (Greenberg et al, 1949;Bellows et al, 1949). The present case, however, confirms the observations of MacArthur (1952) that vaccination during the first trimester of pregnancy may lead to fatal generalized vaccinia in the foetus.…”
Section: Commentsupporting
confidence: 79%
“…Apparently it has been generally accepted that pregnancy is not affected by v,accination (Greenberg et al, 1949;Bellows et al, 1949). The present case, however, confirms the observations of MacArthur (1952) that vaccination during the first trimester of pregnancy may lead to fatal generalized vaccinia in the foetus.…”
Section: Commentsupporting
confidence: 79%
“…6,8,19,21–24,26,28,30,31 Among eight studies that included a comparison group, there was no significantly increased risk of stillbirth with smallpox vaccination (pooled RR 1.03, 95% CI 0.75–1.40) (Table 3). Stillbirth rates ranged from 1.5% to 4.2% among women vaccinated at any time during pregnancy, 0.9–14.7% among those vaccinated in the first trimester, and 1.2–3.9% among the unexposed cohort.…”
Section: Resultsmentioning
confidence: 99%
“…8,19,21–24,28 Although MacArthur et al demonstrated an increased rate of stillbirth in association with first-trimester vaccination exposure (14.7%), the small sample size (n=34) and lack of a control group limit applicability of these findings. 6 Additionally, this meta-analysis found no association between smallpox vaccination and preterm birth.…”
Section: Discussionmentioning
confidence: 99%
“…Urner (1927) was of the opinion that vaccination in pregnancy had no injurious effects on mothers or their infants, but all except one of the 129 expectant mothers were vaccinated after the third month of pregnancy. Bellows et al (1949), from a study of 893 pregnant women, 720 of whom were vaccinated and 173 unvaccinated, considered that smallpox vaccination during pregnancy did not increase the incidence of congenital abnormalities, stillbirths, abortions, or infant deaths. Although the study was a prospective one the control group was very small, and the abortions, stillbirths, and malformations were not analysed according to the stage of pregnancy in weeks when vaccination was performed.…”
Section: Discussionmentioning
confidence: 99%