Effect of smoking on induction of anaesthesia with sevoflurane

Mendonca, Cyprian; Thorpe, Chris

doi:10.1046/j.1365-2044.2001.01790.x

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…Mendonca et al [12] found that inhalational induction with sevoflurane was safe as an induction technique in 60 cigarette smokers. Similar to findings in other patient groups, the use of a high initial concentration reduced induction time.…”

Section: Discussionmentioning

confidence: 99%

Effect of cigarette smoking on the washout time of sevoflurane anesthesia

Adanir¹,

Atay²,

Şencan³

et al. 2010

BMC Anesthesiol

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BackgroundCigarette smoking affects the pharmacodynamic and pharmacokinetic behavior of many drugs and causes deterioration of pulmonary mechanics. We have evaluated the effect of cigarette smoking on washout time after one minimum alveolar concentration-h (1 MAC-h) of sevoflurane anesthesia.MethodsWe investigated the washout time of sevoflurane in 30 non-smoking and 30 healthy cigarette smoking (≥20 cigarettes/day for>1 year) ASA I-II physical status patients, aged 18-63 years, who were candidates for otorhinolaryngologic elective surgery under 1MAC-h standardized sevoflurane anesthesia. At the end of the surgery, the sevoflurane vaporizer was turned off and the time taken for the sevoflurane concentration to decrease to MAC-awake (0.3) and 0.1 MAC levels were recorded. In addition, the ratio of the fractions of inspired concentration (Fi) and expired concentration of sevoflurane (Fexp) at 1 MAC and Fexp of sevoflurane at 0.1MAC were recorded. The patients were mechanically ventilated during the washout time.ResultsWe found no difference between the 2 study groups with regard to washout time of sevoflurane. The times of 1MAC down to MAC-awake (106 ± 48 sec in non-smokers vs 97 ± 37 sec in smokers, p > 0.05) and down to 0.1MAC (491 ± 187 sec in non-smokers vs 409 ± 130 sec in smokers, p > 0.05) were similar. Similarly, there were no significant differences in the ratios of Fi/Fexp at 1MAC (1.18 in non-smokers vs. 1.19 in smokers, p > 0.05) and Fexp of sevoflurane at 0.1MAC (0.26 in non-smokers vs. 0.25 in smokers, p > 0.05).ConclusionsWashout time of 1MAC-h sevoflurane anesthesia is not appear to be effected by cigarette smoking in patients without significant pulmonary disease.

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Section: Discussionmentioning

confidence: 99%

Effect of cigarette smoking on the washout time of sevoflurane anesthesia

Adanir¹,

Atay²,

Şencan³

et al. 2010

BMC Anesthesiol

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show abstract

“…We have found it a useful and convenient method of maintaining ongoing amnesia/anaesthesia during the initial titration doses of ECT that may take several minutes. Many patients about to undergo ECT are heavy smokers; sevoflurane has been demonstrated to be suitable as an induction agent in the smoking population 5 .…”

mentioning

confidence: 99%

Sevoflurane versus Propofol for Induction of Anaesthesia for Electroconvulsive Therapy: A Randomized Crossover Trial

Loughnan

Mckenzie

Leong

2004

Anaesth Intensive Care

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Propofol is often used to induce anaesthesia for electroconvulsive therapy. Some patients who receive propofol have fits of poor quality or inadequate duration despite increasing electroconvulsive therapy doses. Sevoflurane has been reported to exhibit pro-convulsant properties in some "at-risk" patients during anaesthesia for other procedures. The purpose of this study was to perform a randomized crossover trial in patients undergoing electroconvulsive therapy, comparing the effects on seizure parameters of propofol versus sevoflurane induction. Patients were randomly allocated to receive either sevoflurane or propofol for their first treatment. In the subsequent treatment the alternative agent was used. Patients in both treatment groups exhibited equally good fits, with those in the sevoflurane group having slightly better morphology, which is the most subjective of the parameters measured. The sevoflurane administrations were associated with slightly higher pulse rates and blood pressures. Sevoflurane provides a suitable alternative to propofol for anaesthesia in patients undergoing electroconvulsive therapy, although the slightly greater pulse rate rise and blood pressure rise should be considered in patients with ischaemic heart disease.

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“…However, we did not exclude smokers. Previous studies [22,23] have demonstrated that inhalation induction with sevofl urane can be used safely in smokers and that smoking does not augment airway responses to the nominally more pungent anesthetic, desfl urane, more than to the nominally nonpungent sevofl urane. Finally, inhalation induction with desfl urane requires opioid premedication, and this is not available in nebulized form.…”

Section: Discussionmentioning

confidence: 97%