Effect of Smoking on Metalloproteinases (MMPs) Activity in Patients with Acute Myocardial Infarction (AMI)

Sivaraman, Sreekanth K; Zachariah, Geevar; Annamala, P T

doi:10.7860/jcdr/2014/7052.3998

Cited by 12 publications

(17 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the 13 genes associated with ACS, some reportedly are involved in atherothrombotic processes, e.g. IRS2 and MMP9 are involved in plaque disruption and acute myocardial infarction in humans 13–15 and KCNE1 is involved in ischemic events, such as acute myocardial infarction, in a rat model 16 .…”

Section: Discussionmentioning

confidence: 99%

TREML4 mRNA Expression and Polymorphisms in Blood Leukocytes are Associated with Atherosclerotic Lesion Extension in Coronary Artery Disease

Duarte

Miranda

Cruz

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Members of the triggering receptor expressed on myeloid cells (TREM) family are associated with atherosclerosis risk and progression. TREML4 is upregulated in the early phase of acute coronary syndrome. We investigated the relationship between the mRNA expression of 13 genes in blood leukocytes, TREML4 polymorphisms, and coronary artery lesion extension (Friesinger index) in patients with coronary artery disease (CAD) (n = 137). TREML4 rs2803495 (A > G) and rs2803496 (T > C) variants and leukocyte mRNA expression were analysed by qRT-PCR. TREML4 expression was higher in patients with major coronary artery lesions than in subjects without or with low and intermediate lesions ( p < 0.05). However, TREML4 polymorphisms were not associated with coronary lesion extent. Presence of the rs2803495 G allele was not associated with increased TREML4 mRNA expression. Patients carrying the rs2803496 C allele (TC/CC genotypes) were more likely to express TREML4 mRNA than non-C allele carriers (allele C: OR 7.3, and 95% CI 1.9–27.5, p = 0.03). In conclusion, increased TREML4 mRNA expression in blood leukocytes is influenced by gene polymorphisms and is associated with more severe coronary artery lesions, suggesting its potential as a biomarker of the extent of coronary lesions in patients with CAD.

show abstract

Section: Discussionmentioning

confidence: 99%

TREML4 mRNA Expression and Polymorphisms in Blood Leukocytes are Associated with Atherosclerotic Lesion Extension in Coronary Artery Disease

Duarte

Miranda

Cruz

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Of note, exposure to cigarette smoke also increases the expression levels of COX-2 in lung cancer tissue (28). Furthermore, in patients with cardiovascular diseases, several investigators have observed that smoking increases the expression level of MMP-9, but not that of MMP-2 (30,31). Therefore, we hypothesized that smoking may stimulate cancer cell invasion and metastasis by inducing an increase in the expression levels of COX-2 and MMP-9 in patients with UTUC.…”

Section: Discussionmentioning

confidence: 91%

Smoking-induced changes in cancer-related factors in patients with upper tract urothelial cancer

Miyata

Mitsunari

Asai

et al. 2014

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. Cigarette smoking is a major risk factor for urothelial cancer (UC) development. However, the associations between smoking and changes in the pathological characteristics and molecular expression of cancer-related molecules in upper tract (UT) UC have not been fully elucidated. We investigated the associations between smoking status and cancer-related factors, including cancer cell proliferation, apoptosis, angiogenesis, lymphangiogenesis and expression of vascular endothelial growth factor-A and -C, matrix metalloproteinase (MMP)-2 and -9, cyclooxygenase (COX)-2 and urokinase-type plasminogen activator, in patients with UTUC. A total of 134 patients who underwent nephroureterectomy were retrospectively investigated. Proliferation index (PI), microvessel density and lymphatic vessel density (LVD) were measured using anti-Ki-67, anti-CD105 and anti-D2-40 antibodies in formalin-fixed specimens. The apoptotic index was evaluated using the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling method. Other cancer-related molecules were investigated by immunohistochemistry in similar specimens. The patients were divided into three groups; non-smoker (n=54, 40.3%), former smoker (n=46, 34.3%) and current smoker (n=34, 25.4%). The PI and the apoptotic index were not found to be correlated with smoking status; however, the mean/standard deviation level of LVD in current smokers (40.9/12.9) was significantly higher (P= 0.034) compared to that in patients who had never smoked (34.4/10.6). In addition, smoking status was positively correlated with the presence of intratumoral lymphatic vessels (iLV) (P=0.010) and the expression of COX-2 and MMP-9 (P=0.032). The multivariate analysis demonstrated that current smoking was independently associated with all the abovementioned smoking-related factors. However, former smoking was correlated with LVD and the presence of iLV. In the survival analysis, LVD, the presence of iLV and the expression of COX-2 and MMP-9 were identified as predictive factors for metastasis following surgery. In conclusion, lymphangiogenesis and the expression levels of COX-2 and MMP-9 were found to be associated with the smoking status of UTUC patients. Our results may provide important insights into the pathological changes precipitated by smoking in these patients.

show abstract

“… MMP‐9 is a diagnostic marker of inflammation. Activated macrophages and other inflammatory cells are sources of MMPs (including MMP‐9) in the vasculature . Blankenburg et al found that MMP‐9 levels are associated, in patients with coronary artery disease, with cardiac events and cardiac‐induced death.…”

Section: Discussionmentioning

confidence: 99%

“…Smoking induces vascular inflammation. Sivaraman and colleagues found both circulating MMP‐2 and MMP‐9 to be elevated, compared to controls, in patients with acute myocardial infarction (AMI). These authors also observed a significant elevation in MMP‐9 in AMI patients who were smokers compared to those who were nonsmokers.…”

Section: Discussionmentioning

confidence: 99%

Loss of alveolar bone density in postmenopausal, osteopenic women is associated with circulating levels of gelatinases

Thompson

Lee

Stoner

et al. 2019

J of Periodontal Research

View full text Add to dashboard Cite

Objective To determine whether circulating levels of two matrix metalloproteinases, MMP‐2 and MMP‐9, are associated with loss of alveolar bone density (ABD) or height (ABH), or with progression of periodontitis (relative clinical attachment level [RCAL]), among postmenopausal women with local and systemic bone loss. Background This study was planned as part of a 2‐year randomized, double‐blind, placebo‐controlled, clinical trial examining efficacy/safety of subantimicrobial dose doxycycline (20 mg bid) in postmenopausal osteopenic women. This study examines whether serum levels of gelatinases are associated with local changes in the periodontium. Methods A sample of 113 women received periodontal maintenance for moderate to advanced chronic periodontitis and consented to analysis of stored serum biomarkers. Posterior vertical bitewings were taken, and serum collected, at baseline, one, and 2 years. ABD was determined by computer‐assisted densitometric image analysis (CADIA), ABH by the Hausmann et al (1992, J Periodontol 63, 657) method, and RCAL by Florida Probe (every 6 months). MMPs were measured densitometrically on gelatin zymograms using denatured type I collagen as substrate and purified MMP‐2 (72 kDa) and MMP‐9 (92 kDa) as standards. Evidence of worsening in the periodontium at a tooth site was defined as a change from baseline of, for ABD, at least 14 densitometric units (for subcrestal locations) or 17 units (for crestal locations); of at least 0.4 mm for ABH; and of at least 1.5 mm for RCAL. Logistic regression models, while accounting for clustering, compared the odds of worsening in ABD, ABH, or RCAL, after 2 years of observation, between groups defined by baseline and concurrent levels of serum gelatinases. Results Changes in ABH and RCAL were not associated with circulating levels of MMP‐2 or MMP‐9. However, elevated odds of ABD loss over 24 months were associated, among smokers, with both baseline and concurrent levels of MMP‐9 in the middle and highest tertile, and with concurrent levels of MMP‐2 in the middle (but not the highest) tertile. Elevated odds of ABD loss were also associated, among women within 5 years of menopause, with baseline levels of MMP‐2 in the highest tertile. Conclusion Among postmenopausal osteopenic women, loss of ABD was associated, in smokers, with elevated circulating levels of MMP‐9 and MMP‐2. In those within 5 years of menopause, ABD loss was associated with elevated circulating levels of MMP‐2.

show abstract

Effect of Smoking on Metalloproteinases (MMPs) Activity in Patients with Acute Myocardial Infarction (AMI)

Cited by 12 publications

References 29 publications

TREML4 mRNA Expression and Polymorphisms in Blood Leukocytes are Associated with Atherosclerotic Lesion Extension in Coronary Artery Disease

TREML4 mRNA Expression and Polymorphisms in Blood Leukocytes are Associated with Atherosclerotic Lesion Extension in Coronary Artery Disease

Smoking-induced changes in cancer-related factors in patients with upper tract urothelial cancer

Loss of alveolar bone density in postmenopausal, osteopenic women is associated with circulating levels of gelatinases

Contact Info

Product

Resources

About