Effect of smoking, smoking cessation, and nicotine patch on wound dimension, vitamin C, and systemic markers of collagen metabolism

Sørensen, Lars Tue; Toft, Birgitte Grønkær; Rygaard, Jørgen; Ladelund, Steen; Paddon, Maria; James, Tim; Taylor, Richard; Gottrup, Finn

doi:10.1016/j.surg.2010.02.005

Cited by 102 publications

(61 citation statements)

References 54 publications

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“…Several studies have confirmed the impact of smoking on the development of postoperative wound healing complications, in addition to the fact that the incidence of these complications is significantly higher in smokers than in nonsmokers (7,(10)(11)16,(18)(19)(20) .…”

Section: Discussionmentioning

confidence: 91%

“…Sorensen et al, (2010) (16) 48 smokers randomized into groups: G1: smoking; G2: smoking abstinence and use of transdermal nicotine patch; G3: smoking abstinence and placebo. Nonsmokers also participated in the study (n=30 Vitamin C was lower in smokers than in those who were never smokers (average of 54.13 and 110.6, respectively, p<0.01); After smoking cessation, there were increased levels of vitamin C (β = 2.23 0.86, p=0.01); Four-week cigarette abstinence was needed to restore the levels of vitamin C and collagen in the body, improving the inflammatory cell response.…”

Section: Reference Methods Results and Conclusionmentioning

confidence: 99%

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Duration of smoking cessation for the prevention of surgical wound healing complications

Cavichio

Pompeo

Oller

et al. 2014

Rev. esc. enferm. USP

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The study aimed to find scientific evidence about the duration of preoperative smoking cessation required to reduce surgical wound healing complications. An integrative review was performed in the databases, Latin American and Caribbean Literature on Health Sciences (LILACS) and Medical Literature Analysis and Retrieval System Online (MEDLINE), from 08/17/2012 to 09/17/2012, using the keywords: tobacco use cessation and wound healing; tobacco use cessation and preoperative period; tobacco use cessation and perioperative period (LILACS) and tobacco use cessation and perioperative period; tobacco use cessation and wound healing (MEDLINE). Out of the 81 eligible studies, 12 were included. The duration of smoking cessation needed to reduce healing complications was at least four weeks (four studies with level of evidence I, three studies with level of evidence II, two studies with level of evidence IV, and one study with level of evidence VII).

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Section: Discussionmentioning

confidence: 91%

Section: Reference Methods Results and Conclusionmentioning

confidence: 99%

Duration of smoking cessation for the prevention of surgical wound healing complications

Cavichio

Pompeo

Oller

et al. 2014

Rev. esc. enferm. USP

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“…These wounds are useful from an experimental perspective in that their size and depth can be precisely controlled. As they involve all the components of the healing process, they provide an excellent research tool and have been used to investigate angiogenesis (37)(38)(39), wound contraction, and closure (40,41). This model has also been used to investigate the effects of new treatments on wound healing.…”

Section: Animal Models Of Wound Healingmentioning

confidence: 99%

Models of wound healing: an emphasis on clinical studies

Wilhelm

Wilhelm²,

Bielfeldt³

2016

Skin Research and Technology

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Background: The healing of wounds has always provided challenges for the medical community whether chronic or acute. Understanding the processes which enable wounds to heal is primarily carried out by the use of models, in vitro, animal and human. It is generally accepted that the use of human models offers the best opportunity to understand the factors that influence wound healing as well as to evaluate efficacy of treatments applied to wounds. Objectives: The objective of this article is to provide an overview of the different methodologies that are currently used to experimentally induce wounds of various depths in human volunteers and examines the information that may be gained from them. Methods: There is a number of human volunteer healing models available varying in their invasiveness to reflect the different possible depth levels of wounds.Results: Currently available wound healing models include sequential tape stripping, suction blister, abrasion, laser, dermatome, and biopsy techniques. The various techniques can be utilized to induce wounds of variable depth, from removing solely the stratum corneum barrier, the epidermis to even splitthickness or full thickness wounds. Conclusion: Depending on the study objective, a number of models exist to study wound healing in humans. These models provide efficient and reliable results to evaluate treatment modalities. I N VITRO studies and animal models have provided useful information for many breakthroughs and medical advances. However, these are not always appropriate and in many cases are inadequate for discovering the actual pathology responsible. While animal models are suitable for many skin disorders and diseases, they do have their limitations when wound healing is being investigated. The complex biological pathway that occurs during wound healing is not always mirrored in animal models and human models need to be considered. In the case of chronic wound pathology, human models are not always good predictors but they do provide a good understanding of acute wound pathology. Because of the difficulty in obtaining suitable volunteers with chronic wounds and incorporating them into a study, human acute wound models provide the best opportunity to understand the wound healing process and the performance of different products that assist and promote wound healing. This paper evaluates the different wound healing models and discusses the potential for these models to be suitable predictors of wound healing.

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“…The latter factors play a role in either osteogenesis or angiogenesis 27) . In addition, impaired bone formation in smokers might be directly attributed to defective collagen synthesis 22,28) .…”

Section: Discussionmentioning

confidence: 99%

The Osteoporotic Effect of Maras Powder (Turkish Smokeless Tobacco) Consumption in Healthy Males

et al. 2012

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Abstract. [Purpose] This study analyzed the effect of Maraş powder on bone mineral density. [Subjects and Methods] One hundred and eighty-three healthy male subjects (93 Maras powder users, 90 nonusers) were included in the study. The information on demographics, health history, alcohol and tobacco use and medication use were obtained by an interviewer-administered questionnaire. Subjects who had any pathology that might affect bone mineral density, were excluded from the study. Mesurements of bone mineral density were obtained by phalangeal radiographic absorbtiometry of the nondominant hand. The bone mineral density values (g/cm 2 ) of Maraş powder users were compared with those of nonusers.[Results] The mean duration of Maraş powder use was 26 ± 13 years, and the mean age of Maraş powder users was 59 ± 11years. The mean age of nonusers was 58 ± 11years. The mean phalangeal bone mineral density in Maraş powder users (0.32 ± 0.03 g/cm 2 , range 0.22-0.39 g/cm 2 ) was significantly lower than that in the nonusers (0.34 ± 0.03 g/cm 2 , range 0.25-0.43 g/cm 2 , p=0.00).[Conclusion] Bone mineral density is lower in the Maraş powder users than in the nonusers. Maraş powder appears to be a potential risk factor for low bone mineral density in populations where its use is prevalent.

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Effect of smoking, smoking cessation, and nicotine patch on wound dimension, vitamin C, and systemic markers of collagen metabolism

Cited by 102 publications

References 54 publications

Duration of smoking cessation for the prevention of surgical wound healing complications

Duration of smoking cessation for the prevention of surgical wound healing complications

Models of wound healing: an emphasis on clinical studies

The Osteoporotic Effect of Maras Powder (Turkish Smokeless Tobacco) Consumption in Healthy Males

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