Effect of Sodium Alginate on Dextran Sulfate Sodium- and 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Experimental Colitis in Mice

Yamamoto, Atsuki; Itoh, Tomokazu; Nasu, Reishi; Nishida, Ryuichi

doi:10.1159/000353192

Cited by 18 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this way, sodium alginate could suppress indomethacin-induced SII in mice. In agreement with this hypothesis, HMW sodium alginate has been shown to improve inflammation in the lower GIT in an experimental model of colitis 15 , 22 and in methotrexate-induced SII 16 . Here, we also showed that, in addition to HMW sodium alginate, pretreatment with LMW sodium alginate ameliorated indomethacin-induced SII in mice.…”

Section: Discussionsupporting

confidence: 58%

See 1 more Smart Citation

Preventative Effects of Sodium Alginate on Indomethacin-induced Small-intestinal Injury in Mice

et al. 2016

View full text Add to dashboard Cite

Recent advances in diagnostic technologies have revealed that nonsteroidal anti-inflammatory drugs (NSAIDs) can cause serious mucosal injury in the upper and lower gastrointestinal tract (including the small intestine). A drug to treat NSAID-induced small-intestinal injury (SII) is lacking. Sodium alginate is a soluble dietary fiber extracted from brown seaweed and its solution has been used as a hemostatic agent to treat gastrointestinal bleeding due to gastric ulcers. Whether sodium alginate has therapeutic effects on NSAID-induced SII and its mechanism of action are not known. Here, we investigated if administration of two forms (high-molecular-weight (HMW) and low-molecular-weight (LMW)) of sodium alginate could ameliorate indomethacin-induced SII. Pretreatment with HMW sodium alginate or LMW sodium alginate before indomethacin administration improved ulceration and the resultant intestinal shortening was associated with reduced histological severity of mucosal injury and ameliorated mRNA expression of inflammation-related molecules in the small intestine. We found that mRNAs of secretory Muc2 and membrane-associated Muc1, Muc3 and Muc4 were expressed in the small intestine. mRNA expression of Muc1-4 was increased in indomethacin-induced SII, and these increases were prevented by sodium alginate. Thus, administration of sodium alginate could be a therapeutic approach to prevent indomethacin-induced SII.

show abstract

Section: Discussionsupporting

confidence: 58%

“…Sodium alginate is a soluble dietary fiber extracted from brown seaweed. It is a heteropolymer of D-mannuronic acid and L-guluronic acid 15 . The molecular weight of sodium alginate depends on by hydrolysis condition in its production.…”

Section: Introductionmentioning

confidence: 99%

Preventative Effects of Sodium Alginate on Indomethacin-induced Small-intestinal Injury in Mice

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Consequently, we cannot disregard the possibility that alginate composition is important in the potency of anti-inflammatory effects. 30 Hyaluronic acid, another protective solution used in clinical practice, has been recognized as an adjuvant therapy for inflammatory diseases involving the upper aerodigestive tract. There are both basic and clinical research studies to elucidate the anti-inflammatory mechanisms initiated by hyaluronic acid.…”

Section: Discussionmentioning

confidence: 99%

Laryngeal Mucosa Alterations in Mice Model of Gastroesophageal Reflux: Effects of Topical Protection

Figueiredo

Sales

Nicolau³

et al. 2020

The Laryngoscope

View full text Add to dashboard Cite

Objectives/Hypothesis: The objectives of this study were to evaluate laryngeal inflammation and mucosal integrity in a murine model of reflux disease and to assess the protective effects of topical agents including alginate, hyaluronic acid, and cashew gum. Study Design: Animal study. Methods: A surgical murine model of reflux disease was evaluated at 3 or 7 days postsurgery, and laryngeal samples were collected to measure inflammation (wet weight and myeloperoxidase [MPO]) and mucosal integrity (transepithelial resistance [TER] and mucosal permeability to fluorescein). Additional groups of animals were administered one of several topical agents (alginate, hyaluronic acid, or cashew gum) daily, and laryngeal inflammation and mucosal integrity were evaluated at 3 days postsurgery. Results: At 3 days, and not 7 days postsurgery, we observed increased laryngeal wet weight and MPO, decreased laryngeal TER, and increased laryngeal mucosa permeability. Alginate partially decreased laryngeal inflammation (wet weight and not MPO) and dramatically improved laryngeal mucosal integrity. Conversely, hyaluronic acid eliminated the inflammation; however, it had no effect on laryngeal mucosal integrity impairment. Cashew gum eliminated laryngeal inflammation as well as the impairment in laryngeal mucosal integrity. Conclusions: This study shows that a surgical model of reflux disease induced laryngeal inflammation and impairment in laryngeal barrier function. These observed alterations were partially attenuated by alginate and hyaluronic acid and completely reversed by cashew gum.

show abstract

“…Sodium alginate (SA) is a heteropolymer of d -mannuronic acid and l -guluronic acid. It is a soluble dietary fiber extracted from brown algae [8]. SA is in widespread clinical use as a hemostatic agent to treat gastrointestinal tract (GIT) bleeding caused by gastric and duodenal ulcers, erosion of the gastric mucosa, or reflux esophagitis [9].…”

Section: Introductionmentioning

confidence: 99%

“…SA is in widespread clinical use as a hemostatic agent to treat gastrointestinal tract (GIT) bleeding caused by gastric and duodenal ulcers, erosion of the gastric mucosa, or reflux esophagitis [9]. SA has been reported to reduce mucosal damage and inflammation in animal models of inflammatory bowel disease [8].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Sodium Alginate on Hepatic Steatosis in Mice Induced by a Methionine- and Choline-Deficient Diet

et al. 2019

View full text Add to dashboard Cite

Nonalcoholic steatohepatitis (NASH) progresses from nonalcoholic fatty liver disease (NAFLD); however, efficacious drugs for NASH treatment are lacking. Sodium alginate (SA), a soluble dietary fiber extracted from brown algae, could protect the small intestine from enterobacterial invasion. NASH pathogenesis has been suggested to be associated with enterobacterial invasion, so we examined the effect of SA on methionine- and choline-deficient (MCD) diet-induced steatohepatitis in mice (the most widely-used model of NASH). The mice (n = 31) were divided into three groups (mice fed with regular chow, MCD diet, and MCD diet premixed with 5% SA) for 4 and 8 weeks. The MCD diet increased lipid accumulation and inflammation in the liver, the NAFLD Activity Score and hepatic mRNA expression of tumor necrosis factor- and collagen 11, and induced macrophage infiltration. Villus shortening, disruption of zonula occludens-1 localization and depletion of mucus production were observed in the small intestine of the MCD-group mice. SA administration improved lipid accumulation and inflammation in the liver, and impaired barrier function in the small intestine. Collectively, these results suggest that SA is useful for NASH treatment because it can prevent hepatic inflammation and fatty degeneration by maintaining intestinal barrier function.

show abstract

Effect of Sodium Alginate on Dextran Sulfate Sodium- and 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Experimental Colitis in Mice

Cited by 18 publications

References 33 publications

Preventative Effects of Sodium Alginate on Indomethacin-induced Small-intestinal Injury in Mice

Preventative Effects of Sodium Alginate on Indomethacin-induced Small-intestinal Injury in Mice

Laryngeal Mucosa Alterations in Mice Model of Gastroesophageal Reflux: Effects of Topical Protection

Inhibitory Effects of Sodium Alginate on Hepatic Steatosis in Mice Induced by a Methionine- and Choline-Deficient Diet

Contact Info

Product

Resources

About