Effect of sodium balance on intrarenal distribution of blood flow in normal man

Nk, Hollenberg; Epstein, M; Rd, Guttmann; Conroy, M. F.; Basch, Richard I.; Merrill, John P.

doi:10.1152/jappl.1970.28.3.312

Cited by 75 publications

(41 citation statements)

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“…Other possible explanations for nonmodulation, including age, differences in the level of renal damage, differences in basal PAH clearance before administration of All, or clinical differences expressed in the physical exam, electrocardiogram, duration of hypertension, or admission blood pressure, all are unlikely, based both on the data in this study and from previous reports (1,23,24).…”

Section: Discussionmentioning

confidence: 65%

Correction of abnormal renal blood flow response to angiotensin II by converting enzyme inhibition in essential hypertensives.

Redgrave¹,

Rabinowe²,

Hollenberg³

et al. 1985

J. Clin. Invest.

142

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In 40-50% of patients with essential hypertension, a high sodium intake does not increase renal blood flow (RBF). These patients have been defined as nonmodulators because sodium intake does not modulate renal and adrenal responsiveness to angiotensin II (All). To define the role of All in mediating this altered responsiveness, we assessed the effect of a converting enzyme inhibitor (enalapril) on RBF and its responsiveness to All in 25 patients with essential hypertension-10 modulators and 15 nonmodulators-and 9 normotensive controls. After 5 d of a 200-meq sodium intake, the nonmodulators did not increase RBF, whereas the normotensives (79±28 ml/ min per 1.73 m2) and modulators (75±26 ml/min per 1.73 in2) did (P < 0.025). Arterial blood pressure did not change in the modulators with the salt loading, whereas in the nonmodulators, blood pressure rose (P < 0.004).After enalapril administration for 66 h, there was a significant difference (P < 0.01, Fisher Exact Test) in the blood pressure response in the two hypertensive subgroups. In the modulators, there was no change; in the nonmodulators, despite the high salt diet, a blood pressure reduction occurred. In parallel, basal RBF and RBF responsiveness to All were not changed after converting enzyme inhibition in the normotensive control (n = 9) or the hypertensive modulators (n = 10). Conversely, in the nonmodulators (n = 14), the basal RBF increased significantly (83±25 ml/min per 1.73 M2; P = 0.01), the increment being indistinguishable from the response to salt loading in normal subjects. Furthermore, renovascular responsiveness to infused All was also significantly enhanced (P = 0.027) in the nonmodulators, suggesting that enalaprilinduced increase in RBF reflected a fall in intrarenal All levels, and not an increase in prostaglandins or kinins, which would have blunted the renal response to All.Thus, short-term converting enzyme inhibition corrected abnormalities in sodium-mediated modulation of renal vascular responsiveness to All. The close quantitative relation of the increase in RBF with sodium loading in normal subjects and modulators, and with converting enzyme inhibition in nonmodulators, viewed in the context of the effectiveness of enalapril only in the latter, and parallel shifts in sensitivity to All, raises the intriguing possibility that converting enzyme inhibition reversed the failure of the renal blood supply to respond to

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Section: Discussionmentioning

confidence: 65%

Correction of abnormal renal blood flow response to angiotensin II by converting enzyme inhibition in essential hypertensives.

Redgrave¹,

Rabinowe²,

Hollenberg³

et al. 1985

J. Clin. Invest.

142

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“…Studies in man and other experimental animals have shown that a decrease in cortical flow was associated with increased sodium reabsorption while, in situations of increased cortical flow, sodium diuresis occurs [2,4,18,19,37]. In the rat and in the dog saline infusion has been shown to increase filtration rate in superficial nephrons and increase fractional sodium excretion [1,23,53].…”

Section: Discussionmentioning

confidence: 99%

Intrarenal Blood Flow Distribution in Canine Puppies

et al. 1971

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“…Also, Hollenberg et al (12) and Blaufox and coworkers (13) have demonstrated superficial redistribution of blood flow in human subjects on high salt diets using the krypton washout technique.…”

Section: Introductionmentioning

confidence: 99%

“…The only previous experiments on blood flow distribution during dietary variations in salt load have been those of Hollenberg and coworkers (12) and Blaufox et al (13), both of whom demonstrated a superficial redistribution of blood flow on high salt as compared with low salt diets. These studies were performed in human subjects using inert gas washout techniques.…”

mentioning

confidence: 99%

Effect of variation in dietary NaCl intake on the intrarenal distribution of plasma flow in the rat

Blantz¹,

Wallin²,

Rector³

et al. 1972

J. Clin. Invest.

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A B S T R A C T The effect of dietary variation in sodium chloride intake on the intrarenal distribution of plasma flow was investigated in rats using the antiglomerular base~ment membrane antibody technique. Rats were placed on a liquid diet containing either 9.86 (n = 9) or 0 (i = 9) mEq NaCl/daily portion for 2 wk. Labeled antibody was injected and the diets were reversed. After an additional 2 wk period, antibody labeled with a different radionuclide was injected and the animals were sacrificed. Fractional plasma flow distribution was then calculated for each dietary period. No change in flow to any cortical region could be detected. In six additional awake rats on identical dietary regimen, total plasma flow was estimated by the clearance of hippuran-'I. No change in this parameter occurred with changes in NaCl intake. We conclude, therefore, that no change in either total renal plasma flow or intracortical distribution of plasma flow occurs with wide variations in dietary sodium chloride intake in the rat. The implications of this constancy of regional plasma flow are discussed with reference to presumed concomitant alterations in the intrarenal distribution of nephron filtration rate.

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Effect of sodium balance on intrarenal distribution of blood flow in normal man

Cited by 75 publications

References 0 publications

Correction of abnormal renal blood flow response to angiotensin II by converting enzyme inhibition in essential hypertensives.

Correction of abnormal renal blood flow response to angiotensin II by converting enzyme inhibition in essential hypertensives.

Intrarenal Blood Flow Distribution in Canine Puppies

Effect of variation in dietary NaCl intake on the intrarenal distribution of plasma flow in the rat

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