Effect of sodium carboxymethylcellulose and fucidic acid on the gel characterization of polyvinylalcohol-based wound dressing

Abstract

The purpose of this study was to investigate the effect of sodium carboxymethylcellulose (Na-CMC) and fucidic acid on the gel characterization for the development of sodium fucidate-loaded wound dressing. The cross-linked hydrogel films were prepared with polyvinyl alcohol (PVA) and sodium carboxymethylcellulose (Na-CMC) using the freeze-thawing method. Their gel properties such as gel fraction, swelling, water vapor transmission test, morphology, tensile strength and thermal property were investigated. In vitro protein adsorption test and release were performed. Na-CMC decreased the gel fraction and tensile strength of the hydrogels, but increased the swelling ability, water vapor transmission rate, elasticity and porosity of hydrogels. Thus, the wound dressing developed with PVA and Na-CMC was more swellable, flexible and elastic than that with only PVA because of its cross-linking interaction with PVA. However, the drug had a negative effect on the gel properties of hydrogels but there were no significant differences. In particular, the hydrogel composed of 2.5% PVA, 1.125% Na-CMC and 0.2% drug might give an adequate level of moisture and build up the exudates on the wound area. Thus, this sodium fucidate-loaded hydrogel could be a potential candidate for wound dressing with excellent forming.

Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review

“…Polyvinyl alcohol-based composite mixes with gelatin or carboxymethyl cellulose [283,289,290], polyacrylic acid [291], and polyethylene glycol have promising wound healing effects. Polylactic acid-based composites with curcumin and collagen are also emerging as useful biodegradable materials in wound dressing materials [1].…”

Towards Bio-active Restorative Materials with Copaiba Oil and Oblepicha Oil: In vitro

“…These hydroxyl groups can form bridge-type hydrogen bonds within the side chains of hydroxyl, carboxyl, amino or amide groups of the collagen molecules [18][19][20][21][22][23][24]. The formation of these hydrogen bonds is the reason of the stability of chitosan-collagen or fucoidan: collagen interaction [24,25]. By positioning itself between collagen molecules, host: guest complex formed by chitosan: bioactive agent (oblepicha or copaiba oils and its active in) can potentially also form ionic bonds, as well as covalent bonds with collagen fibrils [24,25].…”

“…The formation of these hydrogen bonds is the reason of the stability of chitosan-collagen or fucoidan: collagen interaction [24,25]. By positioning itself between collagen molecules, host: guest complex formed by chitosan: bioactive agent (oblepicha or copaiba oils and its active in) can potentially also form ionic bonds, as well as covalent bonds with collagen fibrils [24,25]. Furthermore, in the process of formation of hydrogen bonds host: guest complex, molecules can replace the water molecules bound to collagen in the extra-complex compartments [24,25].…”

“…It is commonly found in marine brown seaweeds [24]. Fucoidan can increase the level of alkaline phosphatase (ALP), type-1 collagen expression, osteocalcin and BMP-2 and even helps in mineral deposition associated with bone mineralization [25].…”

Biopolymers as Wound Healing Materials: Challenges and New Strategies

“…Hydrogel formulation containing 2.5% PVA, 1.125% Na-CMC and 0.2% sodium fucidate adsorbed exudate from the wound surface adequately and kept the moisture sufficiently in wound area and consequently, it was recommended as an ideal wound dressing material. (Lim et al, 2010).…”